Ankylosing spondylitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The effect of LILRB1 but not LILRA3 gene polymorphism in immunopathology of ankylosing spondylitis-A parallel to KIR genes.
|
30892832 |
2019 |
Ankylosing spondylitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Several genetic studies have assessed the association between polymorphisms in killer immunoglobulin-like receptors (KIR) genes and susceptibility of individuals to ankylosing spondylitis (AS), but the findings have been inconclusive and incongruous.
|
30398028 |
2018 |
Ankylosing spondylitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our results suggest that the AS patients present more activating and less inhibitory KIR genes with combination of their HLA ligands than healthy controls.
|
26996109 |
2016 |
Ankylosing spondylitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
However, we show that the contribution of the KIR genes to AS susceptibility extends beyond the association with individual KIRs, with an imbalance between activating and inhibitory KIR genes seeming to influence the susceptibility to AS.
|
25491925 |
2015 |
Ankylosing spondylitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Our exploratory study indicates that KIR genes are not a major risk factor for susceptibility to AS.
|
26238044 |
2015 |
Ankylosing spondylitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
Sixteen KIR genes were genotyped from 60 unrelated patients with AS and 60 HLA-B27-positive matched healthy controls by PCR-SSP.
|
22744805 |
2013 |
Ankylosing spondylitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The authors analyzed the frequency of 16 KIR genes in Koreans with either AS (110 patients, all HLA-B27-positive) or BD (86 patients), using polymerase chain reaction sequence-specific oligonucleotide probing.
|
23697859 |
2013 |
Ankylosing spondylitis
|
0.100 |
Biomarker
|
disease |
BEFREE |
In this study, the possible association of KIR genes, their known HLA ligands and compound KIR/HLA genotypes with ankylosing spondylitis (AS) was assessed.
|
21797986 |
2011 |
Ankylosing spondylitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The present study was performed to investigate whether the polymorphism of KIR genes and HLA ligands associates with the susceptibility of ankylosing spondylitis (AS).
|
20652381 |
2010 |
Ankylosing spondylitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Suggestive evidence of a role for KIR gene polymorphism in AS exists, but definitive findings are awaited.
|
19496308 |
2009 |
Ankylosing spondylitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Neither the KIR gene content of particular KIR haplotypes nor KIR3DL2 polymorphisms contribute to AS.
|
19019897 |
2009 |
Ankylosing spondylitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Activating KIR genes are associated with ankylosing spondylitis in Asian populations.
|
18638658 |
2008 |
Ankylosing spondylitis
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Thus, the present study was undertaken to determine the association of the polymorphisms KIRs gene and HLA-C alleles with the susceptibility to ankylosing spondylitis (AS) by means of polymerase chain reaction/sequence-specific primers for genotyping KIRs from genomic DNA of 119 patients with AS together with 128 healthy donors as a control group.
|
18297378 |
2008 |