|
Psychotic Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Our aims were to examine: (i) the relationship between DAOA and RGS4 and the risk for psychotic disorders using a family-based association approach, and (ii) whether variations in these genes are associated with differences in patients' cognitive performance.
|
26803614 |
2016 |
|
Psychotic Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Some of the psychosis-only-associated SNPs found in the d-amino acid oxidase activator (DAOA) and the kynurenine 3-monooxygenase (KMO) genes have previously been reported to be associated with schizophrenia.
|
26142836 |
2015 |
|
Psychotic Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
In a prospective cohort (follow-up=2.4-14.9 years) of 225 individuals at ultra-high risk (UHR) for psychosis, we assessed haplotype-tagging single-nucleotide polymorphisms (htSNPs) spanning NRG1 and DAOA for their association with transition to psychosis, using Cox regression analysis.
|
23632455 |
2013 |
|
Psychotic Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
The D-Amino acid oxidase activator (G72 or DAOA) is believed to play a key role in the regulation of central glutamatergic transmission which is seen to be altered in psychosis.
|
21391259 |
2012 |
|
Psychotic Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
The D-amino acid oxidase activator (DAOA, or G72) is involved in the oxidation of D-serine, an endogenous modulator of N-methyl-D-aspartate receptors and thus represents an important candidate in psychotic disorders.
|
21443574 |
2011 |
|
Psychotic Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Assessment of nine common variants in the DAOA/G72 locus yielded two variants with the predictive value for symptom progression: all four probands with the rs1341402 CC genotype developed psychosis compared with 17 out of 78 probands with the TT or CT genotypes (chi(2) = 12.348; df = 2; p = 0.002).
|
19763662 |
2010 |
|
Psychotic Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
The present findings suggest that the G72 gene may contribute to a predisposition to not only schizophrenia but also to methamphetamine psychosis.
|
19482054 |
2009 |
|
Psychotic Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
The DAOA gene may play a role in predisposing individuals to a mixed phenotype of psychosis and mania and to impairments in related neuropsychological traits.
|
18466879 |
2008 |
|
Psychotic Disorders
|
0.100 |
Biomarker
|
group |
BEFREE |
However, recent data suggests that DAOA may influence susceptibility to mood episodes across the spectrum of psychotic disorders rather than contributing to a specific psychosis phenotype.
|
17890006 |
2007 |
|
Psychotic Disorders
|
0.100 |
GeneticVariation
|
group |
LHGDN |
Evidence for association and epistasis at the DAOA/G30 and D-amino acid oxidase loci in an Irish schizophrenia sample.
|
17492767 |
2007 |
|
Psychotic Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
Despite being originally described as a schizophrenia susceptibility locus, our data suggest that variation at the DAOA/G30 locus does not primarily increase susceptibility for prototypical schizophrenia or psychosis.
|
16585465 |
2006 |
|
Psychotic Disorders
|
0.100 |
GeneticVariation
|
group |
BEFREE |
In a logistic regression, "persecutory delusions" were found to be the only significant explanatory variable for the DAOA/G30 risk genotype among 21 OPCRIT symptoms of psychosis.
|
16263850 |
2005 |