GH1, growth hormone 1, 2688

N. diseases: 686; N. variants: 27
Disease: Secondary hypothyroidism ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C3665349
Disease: Secondary hypothyroidism
Secondary hypothyroidism 		0.100 Biomarker disease BEFREE The latest age at diagnosis of GH, ACTH and TSH deficiencies was 9.6, 9.9 and 12.6 years, respectively. 31811804 2020
CUI: C3665349
Disease: Secondary hypothyroidism
Secondary hypothyroidism 		0.100 Biomarker disease BEFREE The gonadotrophin, growth hormone and TSH deficiencies are better defined in the chronic phase. 30931510 2019
CUI: C3665349
Disease: Secondary hypothyroidism
Secondary hypothyroidism 		0.100 Biomarker disease BEFREE The phenotype is likely due to hypothalamic dysfunction, which is responsible for hyperphagia, temperature instability, high pain threshold, hypersomnia and multiple endocrine abnormalities including growth hormone and thyroid-stimulating hormone deficiencies, hypogonadism and central adrenal insufficiency. 26062517 2015
CUI: C3665349
Disease: Secondary hypothyroidism
Secondary hypothyroidism 		0.100 Biomarker disease BEFREE Endocrinological evaluation revealed growth hormone and thyroid-stimulating hormone deficiency. 26302767 2015
CUI: C3665349
Disease: Secondary hypothyroidism
Secondary hypothyroidism 		0.100 Biomarker disease BEFREE Mutations within POU1F1 are associated with GH, TSH and PRL deficiencies, with the TSH deficiency being highly variable. 18174732 2007
CUI: C3665349
Disease: Secondary hypothyroidism
Secondary hypothyroidism 		0.100 Biomarker disease BEFREE Their clinical follow-up showed a wide phenotypic variability: hypogonadism was severe and prevented pubertal development in both, but their final heights were remarkably different, pointing to different degrees in severity of GH/TSH deficiencies; cortisol deficiency developed late in both, but at least 10 yr apart. 17526949 2006
CUI: C3665349
Disease: Secondary hypothyroidism
Secondary hypothyroidism 		0.100 Biomarker disease BEFREE TSH deficiency was manifested after the initiation of GH and was treated with thyroxine while puberty was initiated with conjugated estrogens. 17162714 2006
CUI: C3665349
Disease: Secondary hypothyroidism
Secondary hypothyroidism 		0.100 Biomarker disease BEFREE Studies on Snell and Jackson mice known to have growth hormone, prolactin and thyroid-stimulating hormone deficiencies involving the hypoplastic pituitary gland have led to identifying alterations of the pituitary specific POU homeodomain Pit-1 transcription factor gene. 16879162 2006
CUI: C3665349
Disease: Secondary hypothyroidism
Secondary hypothyroidism 		0.100 Biomarker disease BEFREE Growth hormone and thyroid-stimulating hormone deficiencies were diagnosed concomitantly in all subjects, but at different ages (5.5-10.8 years). 14614227 2003
CUI: C3665349
Disease: Secondary hypothyroidism
Secondary hypothyroidism 		0.100 Biomarker disease BEFREE Pit-1 gene mutations result in complete growth hormone (GH) and PRL deficiencies and variable degrees of TSH deficiency, producing the clinical syndrome of combined pituitary hormone deficiency (CPHD). 9588494 1998
CUI: C3665349
Disease: Secondary hypothyroidism
Secondary hypothyroidism 		0.100 Biomarker disease BEFREE We report a child whose hypothyroidism was recognized clinically at age 6 weeks, and subsequently found to have GH and Prl as well as TSH deficiency. 9485179 1998
CUI: C3665349
Disease: Secondary hypothyroidism
Secondary hypothyroidism 		0.100 Biomarker disease BEFREE However, as the involvement of PIT1 mutation is rare in Russia, the other negative cases need to be analyzed for another candidate gene responsible for combined GH/Pr/TSH deficiency. 9632165 1998
CUI: C3665349
Disease: Secondary hypothyroidism
Secondary hypothyroidism 		0.100 Biomarker disease BEFREE Four out of 10 children in two unrelated families presented with a total pituitary growth hormone (GH) and prolactin deficiency and a partial thyrotropin (TSH) deficiency.The GH gene was intact in family I. 2634610 1989