GIP, gastric inhibitory polypeptide, 2695

N. diseases: 110; N. variants: 7
Disease: Parkinson Disease ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.070 Biomarker disease BEFREE In progressive neurodegenerative disorders such as Alzheimer's and Parkinson's disease, energy utilization is much reduced, and GIP has the potential to reverse this. 31705913 2020
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.070 Biomarker disease BEFREE We have previously shown that analogues of the incretins GLP-1 or GIP have neuroprotective effects in the MPTP mouse model of PD. 29462693 2018
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.070 Biomarker disease BEFREE GLP-1 and GIP mimetics initially designed to treat diabetes show good protective effects in animal models of Alzheimer's and Parkinson's disease. 29402504 2018
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.070 Biomarker disease BEFREE We have previously shown that mimetics of glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) have neuroprotective effects in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropypridine (MPTP) mouse model of PD. 28666800 2017
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.070 Biomarker disease BEFREE We had shown previously that D-Ala2-GIP-glu-PAL, a novel long-acting GIP analogue, can play a neuroprotective role in the PD mouse model induced by acute MPTP injection. 27913104 2017
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.070 Biomarker disease BEFREE These findings together suggest that GIP receptor could be a therapeutic target in the management of symptoms of Parkinson's disease. 28366809 2017
CUI: C0030567
Disease: Parkinson Disease
Parkinson Disease 		0.070 Biomarker disease BEFREE The results demonstrate that dual GLP-1/GIP receptor agonists show promise as a novel treatment for PD. 28223210 2017