Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0342443
Disease: Adrenal Cushing's syndrome
Adrenal Cushing's syndrome 		0.100 AlteredExpression disease BEFREE The molecular mechanisms responsible for glucose-dependent insulinotrophic peptide receptor or gastric inhibitory polypeptide receptor (GIPR) ectopic expression and function in GIP-dependent Cushing's syndrome (CS) are still unknown. 16402925 2006
CUI: C0010481
Disease: Cushing Syndrome
Cushing Syndrome 		0.100 AlteredExpression disease BEFREE The objective of the study was to identify genes differentially expressed specifically in GIP-dependent CS that could be implicated in the ectopic expression of GIPR. 16772347 2006
CUI: C0342443
Disease: Adrenal Cushing's syndrome
Adrenal Cushing's syndrome 		0.100 AlteredExpression disease BEFREE The objective of the study was to identify genes differentially expressed specifically in GIP-dependent CS that could be implicated in the ectopic expression of GIPR. 16772347 2006
CUI: C0007131
Disease: Non-Small Cell Lung Carcinoma
Non-Small Cell Lung Carcinoma 		0.310 Biomarker disease CTD_human Proteomic analysis of secreted proteins of non-small cell lung cancer. 17094902 2006
CUI: C0020456
Disease: Hyperglycemia
Hyperglycemia 		0.200 Biomarker disease RGD Ubiquitination is involved in glucose-mediated downregulation of GIP receptors in islets. 17505054 2007
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases 		0.020 GeneticVariation group BEFREE In conclusion, we identified a common splice site mutation (rs2291726) of the GIP gene which results in a truncated protein and provide preliminary evidence for an association of the heterozygous GIPR Glu354Gln genotype with CVD. 17624916 2007
CUI: C0007222
Disease: Cardiovascular Diseases
Cardiovascular Diseases 		0.020 GeneticVariation group LHGDN In conclusion, we identified a common splice site mutation (rs2291726) of the GIP gene which results in a truncated protein and provide preliminary evidence for an association of the heterozygous GIPR Glu354Gln genotype with CVD. 17624916 2007
CUI: C0524620
Disease: Metabolic Syndrome X
Metabolic Syndrome X 		0.010 GeneticVariation disease BEFREE To investigate whether variations in GIP and GIPR genes are associated with risk factors of the metabolic syndrome we sequenced gene regions and identified two coding SNPs (GIP Ser103Gly, GIPR Glu354Gln) and one splice site SNP (GIP rs2291726) in 47 subjects. 17624916 2007
CUI: C0011847
Disease: Diabetes
Diabetes 		0.040 Biomarker disease BEFREE In the present study, we characterize the age-related sequence of diabetes-associated kidney lesions in GIPR(dn) transgenic mice, a novel mouse model of early-onset diabetes mellitus. 19211686 2009
CUI: C0011849
Disease: Diabetes Mellitus
Diabetes Mellitus 		0.040 Biomarker group BEFREE In the present study, we characterize the age-related sequence of diabetes-associated kidney lesions in GIPR(dn) transgenic mice, a novel mouse model of early-onset diabetes mellitus. 19211686 2009
CUI: C0011881
Disease: Diabetic Nephropathy
Diabetic Nephropathy 		0.010 Biomarker disease BEFREE GIPR(dn) transgenic mice are considered an excellent new tool to study the mechanisms involved in onset and progression of diabetic nephropathy. 19211686 2009
CUI: C0028754
Disease: Obesity
Obesity 		0.200 GeneticVariation disease BEFREE Our data suggest a potential relevance of GIPR variants for obesity. 19254363 2009
CUI: C0011860
Disease: Diabetes Mellitus, Non-Insulin-Dependent
Diabetes Mellitus, Non-Insulin-Dependent 		0.390 Biomarker disease BEFREE Of the three newly implicated loci (GIPR, ADCY5 and VPS13C), only ADCY5 was found to be associated with type 2 diabetes in collaborating studies (n = 35,869 cases, 89,798 controls, OR = 1.12, 95% CI 1.09-1.15, P = 4.8 x 10(-18)). 20081857 2010
CUI: C0017741
Disease: Glucose tolerance test
Glucose tolerance test 		0.100 GeneticVariation phenotype GWASDB Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. 20081857 2010
CUI: C0017741
Disease: Glucose tolerance test
Glucose tolerance test 		0.100 GeneticVariation phenotype GWASCAT Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge. 20081857 2010
CUI: C0028754
Disease: Obesity
Obesity 		0.200 Biomarker disease BEFREE The gastric inhibitory polypeptide receptor (GIPR) modulates body weight and glucose homeostasis and, therefore, represents an interesting candidate gene for obesity and the comorbidity impaired glucose homeostasis. 20516203 2010
CUI: C2362324
Disease: Pediatric Obesity
Pediatric Obesity 		0.010 GeneticVariation disease BEFREE In this study, we screened the GIPR gene for mutations and examined the association between three single-nucleotide polymorphisms (SNPs; rs8111428, rs2302382, rs1800437) and childhood obesity, as well as impaired glucose homeostasis. 20516203 2010
CUI: C0010481
Disease: Cushing Syndrome
Cushing Syndrome 		0.100 Biomarker disease BEFREE Among them, the glucose-dependent insulinotropic polypeptide receptor (GIPR) is already known to play a primary role in the impaired cAMP-dependent cortisol secretion in patients affected by food-dependent Cushing's syndrome. 21554434 2011
CUI: C0342443
Disease: Adrenal Cushing's syndrome
Adrenal Cushing's syndrome 		0.100 Biomarker disease BEFREE Among them, the glucose-dependent insulinotropic polypeptide receptor (GIPR) is already known to play a primary role in the impaired cAMP-dependent cortisol secretion in patients affected by food-dependent Cushing's syndrome. 21554434 2011
CUI: C0001206
Disease: Acromegaly
Acromegaly 		0.020 AlteredExpression disease BEFREE Whether GIPR overexpression in acromegalic patients may be associated with this paradoxical response or more generally involved in the pathogenesis of acromegaly, as suggested by the mutually exclusive high GIPR levels and GNAS1 mutations, remains an open question. 21554434 2011
CUI: C0036341
Disease: Schizophrenia
Schizophrenia 		0.020 GeneticVariation disease BEFREE Association between the GIPR gene and the insulin level after glucose loading in schizophrenia patients treated with olanzapine. 21747410 2012
CUI: C0028754
Disease: Obesity
Obesity 		0.200 Biomarker disease BEFREE The glucose-dependent insulinotropic polypeptide receptor (GIPr) has been implicated in high fat diet-induced obesity and is proposed as an anti-obesity target despite an uncertainty regarding the mechanism of action. 22027838 2011
CUI: C0005893
Disease: Body mass index procedure
Body mass index procedure 		0.100 GeneticVariation phenotype GWASDB Meta-analysis identifies common variants associated with body mass index in east Asians. 22344219 2012
CUI: C0578022
Disease: Finding of body mass index
Finding of body mass index 		0.100 GeneticVariation phenotype GWASDB Meta-analysis identifies common variants associated with body mass index in east Asians. 22344219 2012
CUI: C1305855
Disease: Body mass index
Body mass index 		0.100 GeneticVariation phenotype GWASCAT Meta-analysis identifies common variants associated with body mass index in east Asians. 22344219 2012