|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.390 |
Biomarker
|
disease |
BEFREE |
They interact with their cognate receptors (GIPR and GLP-1R), which are both members of the class B G protein-coupled receptors (GPCRs), and already recognized as targets for treatment of metabolic diseases, such as type 2 diabetes mellitus (T2DM) and obesity.
|
30863364 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.390 |
Biomarker
|
disease |
BEFREE |
GLP-1R agonists are used clinically to treat T2DM but the use of GIPR agonists remains controversial.
|
31330984 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.390 |
GeneticVariation
|
disease |
GWASCAT |
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes.
|
29632382 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
We found a significant association of both the homozygous AA and the minor allele A of GIPR rs2302382 with T2DM.
|
28744963 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.390 |
GeneticVariation
|
disease |
GWASCAT |
Identification of new susceptibility loci for type 2 diabetes and shared etiological pathways with coronary heart disease.
|
28869590 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Moreover, the common variant rs10423928 in the GIPR gene is associated with increased risk of stroke in patients with type 2 diabetes.
|
26395740 |
2016 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.390 |
Biomarker
|
disease |
BEFREE |
We also examined the association of 3 additional loci: CCND2 and GIPR, identified in sex-differentiated analyses, and LAMA1, which was shown to be associated with non-obese European type 2 diabetes.
|
25951451 |
2015 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
We found no detectable effect (with an OR >2.1) of the variants in GCKR, GIPR, ADCY5 and VPS13C on the response to sulfonylurea treatment, indicating that these variants are not significantly contributing to the risk of SH in patients with T2D.
|
22956255 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.390 |
PosttranslationalModification
|
disease |
BEFREE |
Our study provides novel findings on GIPR promoter methylation profile which may improve our ability to understand type 2 diabetes pathogenesis.
|
24086540 |
2013 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.390 |
GeneticVariation
|
disease |
BEFREE |
Genetic variation in the glucose-dependent insulinotropic polypeptide receptor modifies the association between carbohydrate and fat intake and risk of type 2 diabetes in the Malmo Diet and Cancer cohort.
|
22399504 |
2012 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.390 |
Biomarker
|
disease |
BEFREE |
Of the three newly implicated loci (GIPR, ADCY5 and VPS13C), only ADCY5 was found to be associated with type 2 diabetes in collaborating studies (n = 35,869 cases, 89,798 controls, OR = 1.12, 95% CI 1.09-1.15, P = 4.8 x 10(-18)).
|
20081857 |
2010 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.390 |
Biomarker
|
disease |
RGD |
Defective glucose-dependent insulinotropic polypeptide receptor expression in diabetic fatty Zucker rats.
|
11334402 |
2001 |
|
Non-Small Cell Lung Carcinoma
|
0.310 |
AlteredExpression
|
disease |
BEFREE |
Interestingly, six genes (GABBR1, PDE4B, PDE4C, ADCY6, ADCY1 and GIPR) from the cAMP signaling pathway were confirmed to be overexpressed in NSCLCs tissues.
|
28927388 |
2017 |
|
Non-Small Cell Lung Carcinoma
|
0.310 |
Biomarker
|
disease |
CTD_human |
Proteomic analysis of secreted proteins of non-small cell lung cancer.
|
17094902 |
2006 |
|
Body Weight
|
0.300 |
Biomarker
|
phenotype |
CTD_human |
Common variants at CDKAL1 and KLF9 are associated with body mass index in east Asian populations.
|
22344221 |
2012 |
|
Obesity
|
0.200 |
Biomarker
|
disease |
BEFREE |
Glucose-Dependent Insulinotropic Polypeptide Receptor Therapies For The Treatment Of Obesity, Do Agonists = Antagonists?
|
31511854 |
2020 |
|
Obesity
|
0.200 |
Biomarker
|
disease |
BEFREE |
Nonetheless, interrogation of the GIP/GIPR axis on cardiac function in humans will involve the systemic actions of the GIPR within the myocardium and other systems (e.g. adipose tissue, vasculature), which will influence the long-term future of GIPR modification for the treatment of obesity/T2DM.
|
31812593 |
2020 |
|
Obesity
|
0.200 |
Biomarker
|
disease |
BEFREE |
GIPR-deficient mice showed impaired glucose tolerance with reduced β-cell function and resistance to high-fat diet-induced obesity, whereas GIPR agonists improved glycemia and prevented high-fat diet-induced obesity in mice.
|
30637966 |
2019 |
|
Obesity
|
0.200 |
Biomarker
|
disease |
BEFREE |
They interact with their cognate receptors (GIPR and GLP-1R), which are both members of the class B G protein-coupled receptors (GPCRs), and already recognized as targets for treatment of metabolic diseases, such as type 2 diabetes mellitus (T2DM) and obesity.
|
30863364 |
2019 |
|
Obesity
|
0.200 |
Biomarker
|
disease |
BEFREE |
Exon sequencing of GIPR was performed in 164 children with obesity and insulin resistance and in 80 children with paediatric-onset diabetes of unknown origin.
|
30784161 |
2019 |
|
Obesity
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
FTO rs1421085, CDKAL1 rs2206734, TNNl3K rs1514176, GIPR rs11671664 and the GRS were associated with obesity measures at baseline and/or follow-up.
|
26727462 |
2016 |
|
Obesity
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
|
23563607 |
2013 |
|
Obesity
|
0.200 |
Biomarker
|
disease |
BEFREE |
The remaining 7 SNPs are adjacent to, or within, the genes NEGR1, TMEM18, ETV5, FLJ35779, LINGO2, SH2B1 and GIPR, most of which are less well studied than FTO, particularly in the context of obesity.
|
24081222 |
2013 |
|
Obesity
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
|
23563607 |
2013 |
|
Obesity
|
0.200 |
Biomarker
|
disease |
BEFREE |
The glucose-dependent insulinotropic polypeptide receptor (GIPr) has been implicated in high fat diet-induced obesity and is proposed as an anti-obesity target despite an uncertainty regarding the mechanism of action.
|
22027838 |
2011 |