|
Obesity
|
0.200 |
Biomarker
|
disease |
BEFREE |
Glucose-Dependent Insulinotropic Polypeptide Receptor Therapies For The Treatment Of Obesity, Do Agonists = Antagonists?
|
31511854 |
2020 |
|
Obesity
|
0.200 |
Biomarker
|
disease |
BEFREE |
Nonetheless, interrogation of the GIP/GIPR axis on cardiac function in humans will involve the systemic actions of the GIPR within the myocardium and other systems (e.g. adipose tissue, vasculature), which will influence the long-term future of GIPR modification for the treatment of obesity/T2DM.
|
31812593 |
2020 |
|
Obesity
|
0.200 |
Biomarker
|
disease |
BEFREE |
GIPR-deficient mice showed impaired glucose tolerance with reduced β-cell function and resistance to high-fat diet-induced obesity, whereas GIPR agonists improved glycemia and prevented high-fat diet-induced obesity in mice.
|
30637966 |
2019 |
|
Obesity
|
0.200 |
Biomarker
|
disease |
BEFREE |
They interact with their cognate receptors (GIPR and GLP-1R), which are both members of the class B G protein-coupled receptors (GPCRs), and already recognized as targets for treatment of metabolic diseases, such as type 2 diabetes mellitus (T2DM) and obesity.
|
30863364 |
2019 |
|
Obesity
|
0.200 |
Biomarker
|
disease |
BEFREE |
Exon sequencing of GIPR was performed in 164 children with obesity and insulin resistance and in 80 children with paediatric-onset diabetes of unknown origin.
|
30784161 |
2019 |
|
Obesity
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
FTO rs1421085, CDKAL1 rs2206734, TNNl3K rs1514176, GIPR rs11671664 and the GRS were associated with obesity measures at baseline and/or follow-up.
|
26727462 |
2016 |
|
Obesity
|
0.200 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
|
23563607 |
2013 |
|
Obesity
|
0.200 |
Biomarker
|
disease |
BEFREE |
The remaining 7 SNPs are adjacent to, or within, the genes NEGR1, TMEM18, ETV5, FLJ35779, LINGO2, SH2B1 and GIPR, most of which are less well studied than FTO, particularly in the context of obesity.
|
24081222 |
2013 |
|
Obesity
|
0.200 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
|
23563607 |
2013 |
|
Obesity
|
0.200 |
Biomarker
|
disease |
BEFREE |
The glucose-dependent insulinotropic polypeptide receptor (GIPr) has been implicated in high fat diet-induced obesity and is proposed as an anti-obesity target despite an uncertainty regarding the mechanism of action.
|
22027838 |
2011 |
|
Obesity
|
0.200 |
Biomarker
|
disease |
BEFREE |
The gastric inhibitory polypeptide receptor (GIPR) modulates body weight and glucose homeostasis and, therefore, represents an interesting candidate gene for obesity and the comorbidity impaired glucose homeostasis.
|
20516203 |
2010 |
|
Obesity
|
0.200 |
GeneticVariation
|
disease |
BEFREE |
Our data suggest a potential relevance of GIPR variants for obesity.
|
19254363 |
2009 |