Atrial Fibrillation
|
0.300 |
Biomarker
|
disease |
BEFREE |
Immunofluorescence and co-immunoprecipitation studies revealed an interaction between MYL4 and Cx43 with altered localization of Cx43 HCs to the lateral membrane in <i>MYL4</i> mutants, as well as in atrial biopsies from unselected forms of human AF.
|
31735076 |
2020 |
Atrial Fibrillation
|
0.300 |
Biomarker
|
disease |
BEFREE |
Removal of mouse homologues of atrial fibrillation-associated regions in vivo uncovers a distal regulatory region involved in Gja1 (Cx43) expression.
|
31628324 |
2019 |
Atrial Fibrillation
|
0.300 |
Biomarker
|
disease |
BEFREE |
Mechanistically, Ang II upregulated β5i expression to promote ATRAP degradation, which resulted in activation of AT1R-mediated NF-κB signaling, increased NADPH oxidase activity, increased TGF (transforming growth factor)-β1/Smad signaling, and altered the expression of Kir2.1 and CX43 (connexin 43) in the atria, thereby affecting atrial remodeling and AF.
|
30571551 |
2019 |
Atrial Fibrillation
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
We found in our previous study that the level of peripheral blood miR-27b-3p and the expression of atrial tissue CX43 were both significantly downregulated in AF patients.
|
31178968 |
2019 |
Atrial Fibrillation
|
0.300 |
Biomarker
|
disease |
BEFREE |
Cardiac overexpression of perilipin 2 induces atrial steatosis, connexin 43 remodeling, and atrial fibrillation in aged mice.
|
31661297 |
2019 |
Atrial Fibrillation
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
Significant allelic and genotypic associations were identified between NEURL variant rs6584555 and GJA1 variant rs13216675 and AF.
|
29459676 |
2018 |
Atrial Fibrillation
|
0.300 |
Biomarker
|
disease |
BEFREE |
Our results demonstrate that JNK is a critical regulator of Cx43 expression, and that augmented JNK activation in aged atria downregulates Cx43 to impair cell-cell communication and promote the development of AF.
|
29146153 |
2018 |
Atrial Fibrillation
|
0.300 |
Biomarker
|
disease |
BEFREE |
<b>Conclusion:</b> AF vulnerability was higher in old-sed animals, associated with increased atrial fibrosis, lateralization of connexin-43, and reduced atrial conduction velocity.
|
29593565 |
2018 |
Atrial Fibrillation
|
0.300 |
Biomarker
|
disease |
BEFREE |
The induction rate of AF was gradually increased in the RAP + Cx43 siRNA, ISO + RAP and ISO + RAP + Cx43 siRNA groups compared with the N group (P<0.05).
|
29717772 |
2018 |
Atrial Fibrillation
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
The transcription and protein expression of Cx43 in the AF cell model was measured.
|
28554986 |
2017 |
Atrial Fibrillation
|
0.300 |
Biomarker
|
disease |
BEFREE |
The aim of the present study was to investigate the roles of connexin 43 (Cx43) and a1‑adrenergic receptor (α1‑AR) activation in the pathogenesis of system inflammation‑induced AF.
|
28440455 |
2017 |
Atrial Fibrillation
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
We found that increased MIF and extracellular regulated protein kinases (ERK) expression was accompanied by a significant reduction in Cx43 protein expression in atrial tissues from patients with AF compared with those with sinus rhythm.
|
28429502 |
2017 |
Atrial Fibrillation
|
0.300 |
Biomarker
|
disease |
BEFREE |
Gap junctions such as Cx40, Cx43 and Cx45 were proven to participate in both automaticity and conductivity of electrical impulses in SAN and atrial tissue, which was accepted as another link between SND and AF.
|
24825742 |
2014 |
Atrial Fibrillation
|
0.300 |
Biomarker
|
disease |
BEFREE |
The extent of Cx43 immunostaining and its distribution relative to N-cadherin were preserved in the AF patient samples.
|
25200600 |
2014 |
Atrial Fibrillation
|
0.300 |
Biomarker
|
disease |
BEFREE |
Remodeling in AF seems to be similar in men and women, with a tendency for women exhibiting somewhat stronger AF-induced changes in Cx40, which is probably a secondary effect because there is nothing known about hormone sensitivity of the Cx40 promoter, and a not significant tendency for higher Cx43 and collagen I.
|
23315605 |
2013 |
Atrial Fibrillation
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
GJA1 mutations have been associated with cardiac diseases, including atrial fibrillation.
|
22179534 |
2012 |
Atrial Fibrillation
|
0.300 |
AlteredExpression
|
disease |
BEFREE |
This AF-induced increase in lateral/polar expression of Cx43, but not of Cx40, was significantly antagonized by metoprolol treatment.
|
21542828 |
2011 |
Atrial Fibrillation
|
0.300 |
GeneticVariation
|
disease |
BEFREE |
This study reports atrial tissue genetic mosaicism of a novel loss-of-function Cx43 mutation associated with lone AF.
|
20606116 |
2010 |
Atrial Fibrillation
|
0.300 |
Biomarker
|
disease |
RGD |
Immunoblotting revealed that AF did not induce any significant change in Cx43 content in human atria.
|
11527649 |
2001 |