GJA1, gap junction protein alpha 1, 2697

N. diseases: 662; N. variants: 37
Disease: Degenerative polyarthritis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.090 Biomarker disease BEFREE Recent investigations suggest that alterations in different proteins, such as TGF-ß/BMPs, NF-Kß, Wnt, and Cx43, or SASP factors involved in signalling pathways in wound healing response, could be directly implicated in the initiation of OA. 29258883 2018
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.090 Biomarker disease BEFREE The data operation time, intraoperative blood loss, follow-up knee function (Rasmussen score, HSS) and complications (including infection, screw loosening, knee stiffness, knee instability, posttraumatic osteoarthritis, VTE) were extracted. 30081183 2018
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.090 Biomarker disease BEFREE Using an institutional registry from 2007 to 2012, we retrospectively identified patients who underwent a unilateral primary total knee arthroplasty for osteoarthritis and completed a preoperative Lower Extremity Activity Scale (LEAS), a Hospital for Special Surgery Knee Replacement Expectations Survey (HSS-KRES), and a Knee injury and Osteoarthritis Outcome Score (KOOS) evaluation in addition to 2-year KOOS and satisfaction evaluations. 30234618 2018
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.090 Biomarker disease BEFREE This study aimed to translate and adapt the HSS-THRES and HSS-TKRES into Chinese versions (SC-THRES/TKRES) and evaluate their psychometric properties in patients with osteoarthritis (OA) and ankylosing spondylitis (AS). 30031384 2018
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.090 Biomarker disease BEFREE We propose that chondrocytes undergo chondrocyte-mesenchymal transition where increased Cx43-mediated GJIC during OA facilitates Twist-1 nuclear translocation as a novel mechanism involved in OA progression. 30518918 2018
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.090 Biomarker disease BEFREE The myriad roles of Cx43 and its implication in the development of disorders such as cancer, inflammation, osteoarthritis and Alzheimer's disease have given rise to many novel questions. 28167212 2017
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.090 AlteredExpression disease BEFREE Preoperative HSS-KRES did not predict postoperative satisfaction, but higher HSS-KRES predicted higher HSS-KRFES at 1 year, greater improvement in UCLA activity at 6 months and 1 year, and SF-12 Physical Composite Scale and Knee Disability and Osteoarthritis Score at 6 months. 28258830 2017
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.090 AlteredExpression disease BEFREE Using rabbit and human synovial fibroblast cell lines, we examined the effects of Cx43 overexpression and Cx43 siRNA-mediated knockdown on the gene expression of OA-associated matrix metalloproteinases (MMP1 and MMP13), aggrecanases (ADAMTS4 and ADAMTS5), and inflammatory factors (IL1, IL6 and PTGS2) by quantitative real time RT-PCR. 25496568 2014
CUI: C0029408
Disease: Degenerative polyarthritis
Degenerative polyarthritis 		0.090 AlteredExpression disease BEFREE Immunohistochemistry experiments in cartilage from OA patients revealed significantly elevated levels of Cx43 and Cx45 in the superficial zone and down through the next approximately 1000 μm of tissue. 23416160 2013