|
Ventricular arrhythmia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
It was accompanied by downregulation of cardiac Cx43 and PKCε signaling along with an upregulation of myocardial PKCδ and miR-30a rendering the heart prone to ventricular arrhythmias.
|
30446908 |
2019 |
|
Ventricular arrhythmia
|
0.100 |
Biomarker
|
disease |
BEFREE |
MMP-9 overexpression mediates gap junction (GJ) electrical uncoupling induced by Cx43 decreases, while CaMKII upregulation induces transmural dispersion of repolarization (TDR) increase, both of which increase the risk of ventricular arrhythmias (VAs) in denervated transplanted hearts after prolonged cold ischemic storage.
|
30784925 |
2019 |
|
Ventricular arrhythmia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Moreover, we found that dioscin attenuated myocardial IR-induced ventricular arrhythmias via upregulating Cx43 expression and activation.
|
30474396 |
2019 |
|
Ventricular arrhythmia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Indicators of sympathetic neural remodeling and cardiac remodeling were detected to further explore the related mechanisms.Four weeks after MI, rats in the ARNi group exhibited low susceptibility of VAs in comparison with that in the MI group, which was coincident with the attenuation of sympathetic nerve remodeling, amelioration of cardiac fibrosis, and regulation of Cx43 expression.ARNi is effective in reducing VAs in rats with ischemic cardiomyopathy, which is associated with attenuating sympathetic nerve remodeling and myocardial fibrosis.
|
31484876 |
2019 |
|
Ventricular arrhythmia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Six weeks after injection, the expression levels of Cx43 and programmed stimulation-induced ventricular arrhythmias were examined.
|
31555539 |
2019 |
|
Ventricular arrhythmia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Incidence of VAs, serum levels of malondialdehyde (MDA) and superoxide dismutase (SOD), expression of connexin (Cx43), Bcl-2, Bax, caspase-3, tumor necrosis factor (TNF)-α, interleukin-6 (IL-6), and high mobility group box (HMGB)1 were compared.
|
30516302 |
2019 |
|
Ventricular arrhythmia
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
In heterozygous mice with S282 gene substituted with alanine (S282A), we found ventricular arrhythmias with inhibition of Cx43 phosphorylation at both S282 and S279 in the hearts.
|
30981509 |
2019 |
|
Ventricular arrhythmia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
CONCLUSIONS Pinocembrin alleviated ventricular arrhythmia in I/R rats via enhancing Na+-K+ATPase and Ca+-Mg2+ATPase activity and upregulating Cx43 and Kir2.1 protein expression.
|
30022020 |
2018 |
|
Ventricular arrhythmia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
By contrast, expression of non-phosphorylated Cx43 and p-Cx43(Ser278/289), attenuating intercellular communication, was lower in IHH than in N. IHH also resulted in increased expression of protein kinase A and protein kinase G while casein kinase 1 did not change compared to N. In IHH group, which exhibited reduced incidence of ischemic ventricular arrhythmias, Cx43 and p-Cx43(Ser368) were more abundant at "end to end" gap junctions than in N group and this difference was preserved after acute regional ischemia (10 min).
|
30740090 |
2018 |
|
Ventricular arrhythmia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
A single exposure of the dog heart to <sup>12</sup> C irradiation attenuated vulnerability to ventricular arrhythmia after the induction of MI for at least 1 year through the modulation of Cx43 expression.
|
28158934 |
2017 |
|
Ventricular arrhythmia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Our pathology study on explanted and autopsied hearts indicates that the expression of Cx43 was significantly reduced and disturbed in distribution in ARVC/D myocardium with sustained ventricular tachycardia, but not in patients without malignant ventricular arrhythmias.
|
28288337 |
2017 |
|
Ventricular arrhythmia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Injection of Cx-43-MDS/PCs in patients with severe HF led to significant improvement in exercise capacity and myocardial viability of the injected segments while inducing no significant ventricular arrhythmia.
|
28052545 |
2017 |
|
Ventricular arrhythmia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Heterogeneous reduction of Cx43 protein may result in development of malignant ventricular arrhythmia in DCM.
|
12380923 |
2002 |
|
Ventricular arrhythmia
|
0.100 |
Biomarker
|
disease |
BEFREE |
While the Cx43 CKO mice have normal heart structure and contractile function, they die suddenly from spontaneous ventricular arrhythmias.
|
12064616 |
2001 |