GJA1, gap junction protein alpha 1, 2697

N. diseases: 662; N. variants: 37
Disease: Malignant neoplasm of lung ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.350 Biomarker disease BEFREE Insight into the Role and Regulation of Gap Junction Genes in Lung Cancer and Identification of Nuclear Cx43 as a Putative Biomarker of Poor Prognosis. 30845770 2019
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.350 Biomarker disease BEFREE Epac1 is involved in cell cycle progression in lung cancer through PKC and Cx43 regulation. 29528086 2018
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.350 Biomarker disease BEFREE In summary, Cx43 reverses CDDP resistance in A549 CDDP-resistant cells by preventing EMT, making Cx43 a possible therapeutic target for lung cancer. 24789679 2014
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.350 AlteredExpression disease BEFREE Expression of connexin 43 and E-cadherin protein and mRNA in non-small cell lung cancers in Chinese patients. 23621211 2013
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.350 Biomarker disease CTD_human Altered expression of connexins in urethane-induced mouse lung adenomas. 16926031 2006
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.350 Biomarker disease CTD_human Increased susceptibility to urethane-induced lung tumors in mice with decreased expression of connexin43. 15166089 2004
CUI: C0242379
Disease: Malignant neoplasm of lung
Malignant neoplasm of lung 		0.350 AlteredExpression disease BEFREE In accordance with its lack of lung cancer chemopreventive activity, beta-carotene (1-10 microM; 1-5 days treatment durations) did not affect GJIC, gap junction protein (connexin43; Cx43) expression, or growth in vitro of non-transformed (C10) or neoplastic (E9 and 82-132) murine lung epithelial cells. beta-Carotene enhanced GJIC and Cx43 expression and reduced the growth of C3H10T1/2 murine fibroblasts, however. 8950206 1996