Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0566602
Disease: Primary sclerosing cholangitis
Primary sclerosing cholangitis
0.100 Biomarker disease BEFREE Compared with patients with IBD and healthy subjects, the gut microbiota of patients with PSC exhibited a strong disruption in bacteria-fungi correlation network, suggesting an alteration in the interkingdom crosstalk. 31003979 2020
CUI: C0566602
Disease: Primary sclerosing cholangitis
Primary sclerosing cholangitis
0.100 Biomarker disease BEFREE Among 75 patients with active IBD and PSC treated with vedolizumab, 21 patients discontinued vedolizumab before Week 30 [due to lack of efficacy in 19 and malignancy in two patients]. 31056693 2019
CUI: C0566602
Disease: Primary sclerosing cholangitis
Primary sclerosing cholangitis
0.100 GeneticVariation disease BEFREE Large duct PSC and ASC with IBD are risk factors for colectomy and along with female gender, for liver transplant. 29470284 2018
CUI: C0566602
Disease: Primary sclerosing cholangitis
Primary sclerosing cholangitis
0.100 AlteredExpression disease BEFREE Histological staining of Trx1/TrxR1 revealed elevated nuclear Trx1 and TrxR1 staining within cholangiocytes as well as an overall periportal increase in expression in PSC/IBD. 29852184 2018
CUI: C0566602
Disease: Primary sclerosing cholangitis
Primary sclerosing cholangitis
0.100 Biomarker disease BEFREE Primary sclerosing cholangitis (PSC) is the classical hepatobiliary manifestation of IBD. 28428344 2018
CUI: C0566602
Disease: Primary sclerosing cholangitis
Primary sclerosing cholangitis
0.100 Biomarker disease BEFREE Western analysis of PSC/IBD anti-oxidant responses revealed elevated expression of SOD2, GSTπ as well as upregulation of Akt Ser473 phosphorylation. 29180269 2018
CUI: C0566602
Disease: Primary sclerosing cholangitis
Primary sclerosing cholangitis
0.100 Biomarker disease BEFREE Complication-free survival did not differ between SC/IBD and SC patients, but survival was longer in patients without autoimmune features. 29316057 2018
CUI: C0566602
Disease: Primary sclerosing cholangitis
Primary sclerosing cholangitis
0.100 Biomarker disease BEFREE Primary sclerosing cholangitis [PSC] is an idiopathic chronic disorder of the hepatobiliary system associated with inflammatory bowel disease [IBD], mainly ulcerative colitis [UC]. 28383652 2017
CUI: C0566602
Disease: Primary sclerosing cholangitis
Primary sclerosing cholangitis
0.100 Biomarker disease BEFREE Patients with PSC and concomitant IBD are at increased risk of colorectal carcinoma from time of diagnosis and therefore should likely undergo annual surveillance. 28028930 2017
CUI: C0566602
Disease: Primary sclerosing cholangitis
Primary sclerosing cholangitis
0.100 Biomarker disease BEFREE The microbiota of patients with PSC with and without IBD was similar. 26887816 2017
CUI: C0566602
Disease: Primary sclerosing cholangitis
Primary sclerosing cholangitis
0.100 GeneticVariation disease BEFREE Nearly 20% of the IBD-associated CRCs had evidence of primary sclerosing cholangitis. 28050782 2017
CUI: C0566602
Disease: Primary sclerosing cholangitis
Primary sclerosing cholangitis
0.100 Biomarker disease BEFREE The overall genetic architecture of PSC shares features with both autoimmune diseases and IBD. 28293027 2017