NOX1, NADPH oxidase 1, 27035

N. diseases: 142; N. variants: 3
Disease: Endotoxemia ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0376618
Disease: Endotoxemia
Endotoxemia 		0.020 Biomarker phenotype BEFREE Together, these findings suggest that NOX1 in bone marrow-derived cells, but not epithelial cells, perturbs intestinal barrier integrity during endotoxemia. 31838229 2020
CUI: C0376618
Disease: Endotoxemia
Endotoxemia 		0.020 AlteredExpression phenotype BEFREE Consumption of a HFD for 14 weeks caused intestinal permeabilization and endotoxemia, which were associated with a decreased ileum expression of tight junction (TJ) proteins (occludin, ZO-1 and claudin-1), increased expression of NADPH oxidase (NOX1 and NOX4) and NOS2 and oxidative stress, and activation of redox sensitive signals (NF-κB and ERK1/2) that regulate TJ dynamics. 31330482 2019