GJB1, gap junction protein beta 1, 2705

N. diseases: 224; N. variants: 86
Disease: Lung Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.310 Biomarker group LHGDN Enhancing effect of connexin 32 gene on vinorelbine-induced cytotoxicity in A549 lung adenocarcinoma cells. 17569045 2007
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.310 Biomarker group CTD_human These results may indicate a role of Cx32 and Cx43 in urethane-induced lung carcinogenesis, since their absence may contribute to the development of urethane induced lung tumors. 16926031 2006
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.310 Biomarker group CTD_human Cx32-deficient nontumorous lung tissue exhibited an increased proliferative index (P < 0.001), and, after exposure to the carcinogen diethylnitrosamine, Cx32-deficient mice exhibited a highly statistically significant (P < 0.001) increase in bronchioloalveolar lung tumor incidence (28 of 45, 62%) and a 45% increase in average multiplicity compared with wild-type mice (7 of 29, 24%). 15492231 2004