|
Colorectal Carcinoma
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Colorectal-cancer cell lines overexpressing DKK4 showed increased chemoresistance to fluorouracil but not irinotecan or oxaliplatin.
|
22216841 |
2012 |
|
Malignant neoplasm of colon and/or rectum
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Colorectal-cancer cell lines overexpressing DKK4 showed increased chemoresistance to fluorouracil but not irinotecan or oxaliplatin.
|
22216841 |
2012 |
|
Neoplasm Metastasis
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Metastases have higher DKK4 and NOTCH signaling levels and are more chemoresistant than paired subcutaneous xenografts.
|
26006007 |
2015 |
|
Secondary Neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
Metastases have higher DKK4 and NOTCH signaling levels and are more chemoresistant than paired subcutaneous xenografts.
|
26006007 |
2015 |
|
Adenocarcinoma
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Adenocarcinoma (ADCC) patients carrying the heterozygous (CT) genotype for DKK4 rs2073664 showed a better OS compared with wild genotype (log rank p = 0.01).
|
30346805 |
2018 |
|
Malignant neoplasm of colon and/or rectum
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
DICKKOPF-4 and -2 genes are upregulated in human colorectal cancer.
|
19659606 |
2009 |
|
Liver carcinoma
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
DKK4 was down-regulated in 67.5% of HCC cancerous tissues.
|
21994129 |
2012 |
|
Hepatocarcinogenesis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Dickkopf 4 (DKK4) acts as a negative regulator of Wnt/β-catenin pathway but its functional role in liver carcinogenesis has not been studied.
|
22249261 |
2012 |
|
Colorectal Carcinoma
|
0.080 |
Biomarker
|
disease |
BEFREE |
Dickkopf-related protein 4 (DKK4) is a target of the β-catenin/transcription factor 4 complex in colorectal cancer.
|
28356933 |
2017 |
|
Malignant neoplasm of colon and/or rectum
|
0.050 |
Biomarker
|
disease |
BEFREE |
Dickkopf-related protein 4 (DKK4) is a target of the β-catenin/transcription factor 4 complex in colorectal cancer.
|
28356933 |
2017 |
|
Tumor Cell Invasion
|
0.050 |
Biomarker
|
phenotype |
BEFREE |
DKK4-knockdown promoted inhibition of A549/DTX cell growth, and reduced the colony formation and invasion capacity of A549/DTX cells.
|
28981599 |
2017 |
|
Carcinogenesis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
A more distinct comprehension about the effect of DKK4 on tumorigenesis and tumor process will shed light on biomedical research of DKK4 and tumor research.
|
29904276 |
2018 |
|
Tumor-Associated Process
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
A more distinct comprehension about the effect of DKK4 on tumorigenesis and tumor process will shed light on biomedical research of DKK4 and tumor research.
|
29904276 |
2018 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
A more distinct comprehension about the effect of DKK4 on tumorigenesis and tumor process will shed light on biomedical research of DKK4 and tumor research.
|
29904276 |
2018 |
|
Tumor Progression
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Aberrant accumulation of Dickkopf 4 promotes tumor progression via forming the immune suppressive microenvironment in gastrointestinal stromal tumor.
|
31353847 |
2019 |
|
ADRENOCORTICAL CARCINOMA, HEREDITARY
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Adenocarcinoma (ADCC) patients carrying the heterozygous (CT) genotype for DKK4 rs2073664 showed a better OS compared with wild genotype (log rank p = 0.01).
|
30346805 |
2018 |
|
Increased drug resistance
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Analysis of cell viability in the control and DKK4 over-expressing cell lines, following treatment with 5-fluorouracil (5-Fu), YN968D1 or both, indicated that DKK4 over-expressing cells exhibit increased drug resistance.
|
28356933 |
2017 |
|
Malignant neoplasm of breast
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Apart from these five variants, rs3923086 in AXIN2 and rs3763511 in DKK4 that did not show any association in the overall population were significantly associated with early on-set and estrogen receptor negative breast cancers, respectively.
|
23516639 |
2013 |
|
Schizophrenia
|
0.310 |
Biomarker
|
disease |
BEFREE |
As DKK family members have previously been found to show altered expression in schizophrenia brain and to bind to neuregulin, this finding suggests that DKK4 may play a role in schizophrenia pathogenesis.
|
17553464 |
2008 |
|
Schizophrenia
|
0.310 |
Biomarker
|
disease |
LHGDN |
As DKK family members have previously been found to show altered expression in schizophrenia brain and to bind to neuregulin, this finding suggests that DKK4 may play a role in schizophrenia pathogenesis.
|
17553464 |
2008 |
|
Schizophrenia
|
0.310 |
Biomarker
|
disease |
PSYGENET |
As DKK family members have previously been found to show altered expression in schizophrenia brain and to bind to neuregulin, this finding suggests that DKK4 may play a role in schizophrenia pathogenesis.
|
17553464 |
2008 |
|
Adenoma
|
0.010 |
Biomarker
|
group |
BEFREE |
Because Dickkopf-4, a member of the Dickkopf family acting as a Wnt-signaling modulator, was identified as one of the upregulated genes in this specimen, we investigated expression profiles of all the Dickkopf family members in 55 colorectal tumors (21 cancers and 34 adenomas).
|
19659606 |
2009 |
|
Carcinogenesis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
By activating other pathways apart from the Wnt/β-catenin pathway, DKK4 may play an important role in ccRCC tumorigenesis and metastasis.
|
24573574 |
2014 |
|
Neoplasm Metastasis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
By activating other pathways apart from the Wnt/β-catenin pathway, DKK4 may play an important role in ccRCC tumorigenesis and metastasis.
|
24573574 |
2014 |
|
Colorectal Carcinoma
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Compared with normal adjacent mucosae, Dickkopf-4 (median 27.4, P < 0.01) and -2 (median 51.4, P < 0.01) were strongly expressed in colorectal cancers.
|
19659606 |
2009 |