|
Schizophrenia
|
0.310 |
Biomarker
|
disease |
BEFREE |
As DKK family members have previously been found to show altered expression in schizophrenia brain and to bind to neuregulin, this finding suggests that DKK4 may play a role in schizophrenia pathogenesis.
|
17553464 |
2008 |
|
Schizophrenia
|
0.310 |
Biomarker
|
disease |
LHGDN |
As DKK family members have previously been found to show altered expression in schizophrenia brain and to bind to neuregulin, this finding suggests that DKK4 may play a role in schizophrenia pathogenesis.
|
17553464 |
2008 |
|
Schizophrenia
|
0.310 |
Biomarker
|
disease |
PSYGENET |
As DKK family members have previously been found to show altered expression in schizophrenia brain and to bind to neuregulin, this finding suggests that DKK4 may play a role in schizophrenia pathogenesis.
|
17553464 |
2008 |
|
Anorectal Malformations
|
0.300 |
Biomarker
|
group |
GENOMICS_ENGLAND |
Genome-wide copy number variation study in anorectal malformations.
|
23108157 |
2013 |
|
Bipolar Disorder
|
0.300 |
Biomarker
|
disease |
PSYGENET |
Molecular genetics and developmental studies have identified 21 genes in this region (ADRA1A, ARHGEF10, CHRNA2, CHRNA6, CHRNB3, DKK4, DPYSL2, EGR3, FGF17, FGF20, FGFR1, FZD3, LDL, NAT2, NEF3, NRG1, PCM1, PLAT, PPP3CC, SFRP1 and VMAT1/SLC18A1) that are most likely to contribute to neuropsychiatric disorders (schizophrenia, autism, bipolar disorder and depression), neurodegenerative disorders (Parkinson's and Alzheimer's disease) and cancer.
|
19204725 |
2009 |
|
Mental Depression
|
0.300 |
Biomarker
|
disease |
PSYGENET |
Molecular genetics and developmental studies have identified 21 genes in this region (ADRA1A, ARHGEF10, CHRNA2, CHRNA6, CHRNB3, DKK4, DPYSL2, EGR3, FGF17, FGF20, FGFR1, FZD3, LDL, NAT2, NEF3, NRG1, PCM1, PLAT, PPP3CC, SFRP1 and VMAT1/SLC18A1) that are most likely to contribute to neuropsychiatric disorders (schizophrenia, autism, bipolar disorder and depression), neurodegenerative disorders (Parkinson's and Alzheimer's disease) and cancer.
|
19204725 |
2009 |
|
Depressive disorder
|
0.300 |
Biomarker
|
disease |
PSYGENET |
Molecular genetics and developmental studies have identified 21 genes in this region (ADRA1A, ARHGEF10, CHRNA2, CHRNA6, CHRNB3, DKK4, DPYSL2, EGR3, FGF17, FGF20, FGFR1, FZD3, LDL, NAT2, NEF3, NRG1, PCM1, PLAT, PPP3CC, SFRP1 and VMAT1/SLC18A1) that are most likely to contribute to neuropsychiatric disorders (schizophrenia, autism, bipolar disorder and depression), neurodegenerative disorders (Parkinson's and Alzheimer's disease) and cancer.
|
19204725 |
2009 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
In addition, tumor-derived DKK4 could decrease immune cells infiltration and activation in the tumor microenvironment, which decreased the antitumor effects in return.
|
31353847 |
2019 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
A more distinct comprehension about the effect of DKK4 on tumorigenesis and tumor process will shed light on biomedical research of DKK4 and tumor research.
|
29904276 |
2018 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
GO and pathway analysis showed that DKK4 are associated with tumor and organ development and immune inflammation.
|
26880586 |
2016 |
|
Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Interestingly, in NOD/SCID mice supplemented with high glucose, HepG2 xenografted tumors grew rapidly in which elevated levels of β-catenin, c-Myc and decreased levels of DKK4 were detected.
|
27272409 |
2016 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
Stable DKK4-transfected cells were established, and DKK4 functional analyses were performed, including a T-cell factor/lymphoid enhancer factor (TCF/LEF) reporter assay, and experiments on cell viability, apoptosis, invasive capability and tumor growth in vivo.
|
24573574 |
2014 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
J7-DKK4 and J7-TRα1 overexpressing mice, which displayed growth arrest, lower lung colony formation index, and smaller tumor size than in control mice, supporting an inhibitory role of DKK4 in tumor progression.
|
21994129 |
2012 |
|
Neoplasms
|
0.090 |
PosttranslationalModification
|
group |
BEFREE |
Only DKK4 exhibited similarly high methylation levels in both tumour and normal specimens, while DACT1 was always essentially unmethylated.
|
22672427 |
2012 |
|
Neoplasms
|
0.090 |
Biomarker
|
group |
BEFREE |
When DKK4-expressing 97L stable cells were used to induce tumour xenografts in nude mice (n=8), reduction in tumour sizes was observed (P=0.027).
|
22249261 |
2012 |
|
Neoplasms
|
0.090 |
AlteredExpression
|
group |
BEFREE |
Remarkably, expression of DKK-4 messenger RNA (mRNA) was not detected in a series of 29 human normal (N) colon biopsies but expression was upregulated in all the matched tumour (T) tissues.
|
18408752 |
2008 |
|
Colorectal Carcinoma
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
We studied thirteen single nucleotide polymorphisms (SNPs) located in SFRP3 (rs7775), CTNNB1 (β-catenin) [rs4135385, rs13072632], APC (rs454886, rs459552), LRP6 (rs2075241, rs2284396), DKK4 (rs3763511), DKK3 (rs6485350), TCF4 (rs12255372) and AXIN2 (rs3923086, rs3923087, rs4791171) in patients with colorectal cancer (n = 122) and controls (n = 110).
|
31485167 |
2019 |
|
Colorectal Carcinoma
|
0.080 |
GeneticVariation
|
disease |
BEFREE |
We found that LGR5 expression in the epithelium and stroma was associated with tumor stage, and by integrating functional experiments with LGR5-sorted cell RNA sequencing data from adenoma and normal organoids, we found correlations between LGR5 and CRC-specific genes, including dickkopf WNT signaling pathway inhibitor 4 (<i>DKK4</i>) and SPARC-related modular calcium binding 2 (<i>SMOC2</i>).
|
29467240 |
2018 |
|
Colorectal Carcinoma
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
These findings uncover a critical role for TCF7L1 in repressing DKK4 gene expression to promote the oncogenic potential of CRCs.
|
28450117 |
2017 |
|
Colorectal Carcinoma
|
0.080 |
Biomarker
|
disease |
BEFREE |
Dickkopf-related protein 4 (DKK4) is a target of the β-catenin/transcription factor 4 complex in colorectal cancer.
|
28356933 |
2017 |
|
Colorectal Carcinoma
|
0.080 |
Biomarker
|
disease |
BEFREE |
Our discovery of exosome-mediated secretion of DKK4 opens up the possibility that exosomal DKK4 may be a mechanism used by epithelial colon cells to regulate Wnt signaling which is lost during CRC progression.
|
22740476 |
2012 |
|
Colorectal Carcinoma
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Colorectal-cancer cell lines overexpressing DKK4 showed increased chemoresistance to fluorouracil but not irinotecan or oxaliplatin.
|
22216841 |
2012 |
|
Colorectal Carcinoma
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
Compared with normal adjacent mucosae, Dickkopf-4 (median 27.4, P < 0.01) and -2 (median 51.4, P < 0.01) were strongly expressed in colorectal cancers.
|
19659606 |
2009 |
|
Colorectal Carcinoma
|
0.080 |
AlteredExpression
|
disease |
BEFREE |
We report that DKK4 is frequently down-regulated in colorectal cancer cell lines with deregulated beta-catenin/Tcf-4 and in primary colorectal cancers.
|
19059704 |
2009 |
|
Malignant neoplasm of colon and/or rectum
|
0.050 |
GeneticVariation
|
disease |
BEFREE |
We studied thirteen single nucleotide polymorphisms (SNPs) located in SFRP3 (rs7775), CTNNB1 (β-catenin) [rs4135385, rs13072632], APC (rs454886, rs459552), LRP6 (rs2075241, rs2284396), DKK4 (rs3763511), DKK3 (rs6485350), TCF4 (rs12255372) and AXIN2 (rs3923086, rs3923087, rs4791171) in patients with colorectal cancer (n = 122) and controls (n = 110).
|
31485167 |
2019 |