|
Cardiomyopathy, Dilated
|
0.110 |
GeneticVariation
|
group |
BEFREE |
Association between polymorphisms of the HSPB7 gene and Cheyne-Stokes respiration with central sleep apnea in patients with dilated cardiomyopathy and congestive heart failure.
|
27441470 |
2016 |
|
Cardiomyopathy, Dilated
|
0.110 |
GeneticVariation
|
group |
GWASDB |
Genetic association study identifies HSPB7 as a risk gene for idiopathic dilated cardiomyopathy.
|
20975947 |
2010 |
|
Body Height
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Leveraging Polygenic Functional Enrichment to Improve GWAS Power.
|
30595370 |
2019 |
|
Systolic Pressure
|
0.100 |
GeneticVariation
|
phenotype |
GWASCAT |
Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney.
|
28739976 |
2017 |
|
Congestive heart failure
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
Several mutations within HSPB7 are associated with dilated cardiomyopathy and heart failure in human patients.
|
29078393 |
2017 |
|
Congestive heart failure
|
0.070 |
Biomarker
|
disease |
BEFREE |
Heat shock protein beta-7 (HSPB7) displayed differences in abundance in tissue and serum at an early stage of HF.
|
28973020 |
2017 |
|
Congestive heart failure
|
0.070 |
Biomarker
|
disease |
BEFREE |
In the present study, we generated a cardiac-specific inducible HSPB7 knockout mouse and demonstrated that the loss of HSPB7 in cardiomyocytes results in rapid heart failure and sudden death.
|
28827800 |
2017 |
|
Congestive heart failure
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
Association between polymorphisms of the HSPB7 gene and Cheyne-Stokes respiration with central sleep apnea in patients with dilated cardiomyopathy and congestive heart failure.
|
27441470 |
2016 |
|
Congestive heart failure
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
Of 51 exonic CLCNKA variants identified, one SNP (rs10927887, encoding Arg83Gly) was common, in linkage disequilibrium with the heart failure risk SNP in HSPB7, and associated with heart failure in two independent Caucasian referral populations (n = 2,606 and 1,168; combined P = 2.25 × 10(-6)).
|
21248228 |
2011 |
|
Congestive heart failure
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
Two intronic single-nucleotide polymorphisms showed replicated associations with all-cause heart failure as follows: rs1739843 in HSPB7 (combined P=3.09x10(-6)) and rs6787362 in FRMD4B (P=6.09x10(-6)).
|
20124441 |
2010 |
|
Congestive heart failure
|
0.070 |
GeneticVariation
|
disease |
BEFREE |
These results establish the power and applicability of pooled resequencing for comparative SNP association analysis of target subgenomes in large populations and identify an association between multiple HSPB7 polymorphisms and heart failure.
|
20038796 |
2010 |
|
Heart failure
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Several mutations within HSPB7 are associated with dilated cardiomyopathy and heart failure in human patients.
|
29078393 |
2017 |
|
Heart failure
|
0.060 |
Biomarker
|
disease |
BEFREE |
In the present study, we generated a cardiac-specific inducible HSPB7 knockout mouse and demonstrated that the loss of HSPB7 in cardiomyocytes results in rapid heart failure and sudden death.
|
28827800 |
2017 |
|
Heart failure
|
0.060 |
Biomarker
|
disease |
BEFREE |
Heat shock protein beta-7 (HSPB7) displayed differences in abundance in tissue and serum at an early stage of HF.
|
28973020 |
2017 |
|
Heart failure
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Of 51 exonic CLCNKA variants identified, one SNP (rs10927887, encoding Arg83Gly) was common, in linkage disequilibrium with the heart failure risk SNP in HSPB7, and associated with heart failure in two independent Caucasian referral populations (n = 2,606 and 1,168; combined P = 2.25 × 10(-6)).
|
21248228 |
2011 |
|
Heart failure
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
Two intronic single-nucleotide polymorphisms showed replicated associations with all-cause heart failure as follows: rs1739843 in HSPB7 (combined P=3.09x10(-6)) and rs6787362 in FRMD4B (P=6.09x10(-6)).
|
20124441 |
2010 |
|
Heart failure
|
0.060 |
GeneticVariation
|
disease |
BEFREE |
These results establish the power and applicability of pooled resequencing for comparative SNP association analysis of target subgenomes in large populations and identify an association between multiple HSPB7 polymorphisms and heart failure.
|
20038796 |
2010 |
|
Cardiomyopathy, Familial Idiopathic
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
We aimed to explore the prevalence of polymorphisms of the HSPB7 gene in the Chinese Han population with CSR-CSA and CHF caused by DCM.
|
27441470 |
2016 |
|
Cardiomyopathy, Familial Idiopathic
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
There was no difference in genotype or allele frequencies in ACTC1 or HSPB7 between DCM patients and control subjects.
|
23570452 |
2013 |
|
Cardiomyopathy, Familial Idiopathic
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
Three DCM-associated SNPs were confirmed by individual genotyping (P < 5.0 10(-7)), and two of them, rs10927875 and rs2234962, were replicated in independent samples (1165 DCM patients and 1302 controls), with P-values of 0.002 and 0.009, respectively. rs10927875 maps to a region on chromosome 1p36.13 which encompasses several genes among which HSPB7 has been formerly suggested to be implicated in DCM.
|
21459883 |
2011 |
|
Cardiomyopathy, Familial Idiopathic
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
The analysis revealed a significant association between a SNP in HSPB7 gene (rs1739843, minor allele frequency 39%) and idiopathic DCM (p = 1.06 × 10⁻⁶, OR = 0.67 [95% CI 0.57-0.79] for the minor allele T).Three more SNPs showed p < 2.21 × 10⁻⁵.
|
20975947 |
2010 |
|
Malignant Neoplasms
|
0.020 |
PosttranslationalModification
|
group |
BEFREE |
This study demonstrated that SRARP and HSPB7 are a gene pair located 5.2 kb apart on 1p36.13 and are inactivated by deletions and epigenetic silencing in malignancies.
|
29577611 |
2018 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Importantly, SRARP and HSPB7 have tumor suppressor functions in clonogenicity and cell viability associated with the downregulation of Akt and ERK.
|
29577611 |
2018 |
|
Cardiomyopathies
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Inhibiting autophagy caused FilaminC aggregation in HSPB7 mutant human cardiomyocytes and developmental cardiomyopathy in hspb7 mutant zebrafish embryos.
|
29331499 |
2018 |
|
Cardiomyopathies
|
0.020 |
GeneticVariation
|
group |
BEFREE |
Additionally, several single-nucleotide polymorphisms of HSPB7 have been identified to be associated with heart failure caused by cardiomyopathy in human patients.
|
28827800 |
2017 |