DISC1, DISC1 scaffold protein, 27185

N. diseases: 136; N. variants: 44
Disease: Anxiety ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0003467
Disease: Anxiety
Anxiety 		0.030 Biomarker disease BEFREE TgDISC1 rats showed enhanced anxiety behavior in the EPM and an impairment in attention-like/short-term working-memory in the SAB. 30779934 2019
CUI: C0003467
Disease: Anxiety
Anxiety 		0.030 GeneticVariation disease BEFREE NRG1×DISC1 mutant mice were generated and adult mice from each genotype were assessed for pain sensitivity (hot plate and tail flick tests), anxiety (light-dark box), and stress-induced hypothermia. 27916686 2017
CUI: C0003467
Disease: Anxiety
Anxiety 		0.030 AlteredExpression disease BEFREE Expression of mutant DISC1 in astrocytes decreased neural progenitor proliferation and dendrite growth of newborn neurons, and produced elevated anxiety, attenuated social behaviors, and impaired hippocampus-dependent learning and memory. 28631721 2017