|
Fatty Liver
|
0.010 |
Biomarker
|
disease |
BEFREE |
The loss of liver glycine N-methyltransferase (GNMT) promotes liver steatosis and the transition to hepatocellular carcinoma (HCC).
|
30850319 |
2019 |
|
Inborn Errors of Metabolism
|
0.010 |
GeneticVariation
|
group |
BEFREE |
This mini review will provide a summary of the biochemical pathways, in which choline is involved and their respective inborn errors of metabolism (caused by mutations in SLC5A7, CHAT, SLC44A1, CHKB, PCYT1A, CEPT1, CAD; DHODH, UMPS, FMO3, DMGDH, and GNMT).
|
30681159 |
2019 |
|
Steatohepatitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
The loss of liver glycine N-methyltransferase (GNMT) promotes liver steatosis and the transition to hepatocellular carcinoma (HCC).
|
30850319 |
2019 |
|
Cholestasis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Correlation between GNMT and miR-873-5p in human cholestasis and cirrhosis together with miR-873-5p inhibition in vivo in different mouse models of liver cholestasis and fibrosis [bile duct ligation and Mdr2 (Abcb4)<sup>-/-</sup> mouse] were then assessed.
|
30237481 |
2018 |
|
Kidney Diseases
|
0.010 |
Biomarker
|
group |
BEFREE |
In summary, hepatic GNMT protected mice from AAI nephropathy by enhancing CAR/PXR/CYP3A44/3A41 transcriptions and reducing Nrf2/NQO1 transcriptions.
|
29725048 |
2018 |
|
Hepatic fibrosis and cirrhosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
To date, little is known about the mechanisms underlying downregulation of GNMT levels in hepatic fibrosis and cirrhosis.
|
30237481 |
2018 |
|
Cleft Lip with or without Cleft Palate
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
This study is novel in finding that common glycine N-methyltransferase variant genotypes increase the risk of cleft lip with or without cleft palate.
|
30318092 |
2018 |
|
Cholestatic hepatic disorder
|
0.010 |
Biomarker
|
disease |
BEFREE |
Correlation between GNMT and miR-873-5p in human cholestasis and cirrhosis together with miR-873-5p inhibition in vivo in different mouse models of liver cholestasis and fibrosis [bile duct ligation and Mdr2 (Abcb4)<sup>-/-</sup> mouse] were then assessed.
|
30237481 |
2018 |
|
Cirrhosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Correlation between GNMT and miR-873-5p in human cholestasis and cirrhosis together with miR-873-5p inhibition in vivo in different mouse models of liver cholestasis and fibrosis [bile duct ligation and Mdr2 (Abcb4)<sup>-/-</sup> mouse] were then assessed.
|
30237481 |
2018 |
|
Aristolochic Acid Nephropathy
|
0.010 |
Biomarker
|
disease |
BEFREE |
Glycine N-methyltransferase inhibits aristolochic acid nephropathy by increasing CYP3A44 and decreasing NQO1 expression in female mouse hepatocytes.
|
29725048 |
2018 |
|
Congenital Heart Defects
|
0.010 |
GeneticVariation
|
group |
BEFREE |
Single nucleotide polymorphism in infant genes in the folate (MTHFS rs12438477), homocysteine (TRDMT1 rs6602178 and GNMT rs11752813) and transsulfuration (GSTP1 rs7941395 and MGST1 rs7294985) pathways were also associated with an increased risk of congenital heart defects.<b>Conclusions</b> Common maternal or infant genetic variants in folate, homocysteine, or transsulfuration pathways are associated with an increased risk of certain congenital heart defects among children of women taking SSRIs during cardiogenesis.
|
28264803 |
2017 |
|
Adenocarcinoma of pancreas
|
0.010 |
Biomarker
|
disease |
BEFREE |
Epigenetic Silencing of GNMT Gene in Pancreatic Adenocarcinoma.
|
25560641 |
2015 |
|
ANOPHTHALMIA AND PULMONARY HYPOPLASIA
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Collectively, these data indicate that GNMT is aberrantly methylated in PDAC representing, thus, a potential major mechanism for gene silencing.
|
25560641 |
2015 |
|
Malignant neoplasm of breast
|
0.010 |
Biomarker
|
disease |
BEFREE |
Expression of sarcosine metabolism-related proteins differed significantly according to breast cancer subtype (GNMT, p=0.005; SARDH, p=0.012; tumoral PIPOX, p=0.008; stromal PIPOX, p<0.001).
|
24884785 |
2014 |
|
melanoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
A diagnostic algorithm that incorporates methylation of the CLDN11, CDH11, PPP1R3C, MAPK13, and GNMT genes was validated in an independent sample set and helped distinguish melanoma from dysplastic nevus (area under the curve 0.81).
|
24999589 |
2014 |
|
Dysplastic Nevus
|
0.010 |
Biomarker
|
disease |
BEFREE |
A diagnostic algorithm that incorporates methylation of the CLDN11, CDH11, PPP1R3C, MAPK13, and GNMT genes was validated in an independent sample set and helped distinguish melanoma from dysplastic nevus (area under the curve 0.81).
|
24999589 |
2014 |
|
Breast Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Expression of sarcosine metabolism-related proteins differed significantly according to breast cancer subtype (GNMT, p=0.005; SARDH, p=0.012; tumoral PIPOX, p=0.008; stromal PIPOX, p<0.001).
|
24884785 |
2014 |
|
Metastatic Prostate Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
It was recently reported that sarcosine, which is regulated by GNMT, increased markedly in metastatic prostate cancer.
|
24800880 |
2014 |
|
Metastasis from malignant tumor of prostate
|
0.010 |
Biomarker
|
disease |
BEFREE |
It was recently reported that sarcosine, which is regulated by GNMT, increased markedly in metastatic prostate cancer.
|
24800880 |
2014 |
|
Malignant Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
These results are valuable for the study of the influence of androgen on the gene expression of GNMT especially in the pathogenesis of cancer.
|
23883094 |
2013 |
|
Primary malignant neoplasm
|
0.010 |
AlteredExpression
|
group |
BEFREE |
These results are valuable for the study of the influence of androgen on the gene expression of GNMT especially in the pathogenesis of cancer.
|
23883094 |
2013 |
|
Hypercholesterolemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, GNMT was downregulated in the liver tissues from patients suffering with NAFLD as well as from mice fed a high-fat diet, high-cholesterol diet or methionine/choline-deficient diet.
|
22183894 |
2012 |
|
Schizophrenia
|
0.010 |
Biomarker
|
disease |
BEFREE |
GNMT plays an important role in maintaining normal physiological function of brain and Tg-GNMT/Gnmt-/- mice are useful models for development of therapeutics for patients with schizophrenia.
|
22264868 |
2012 |
|
Hepatocarcinogenesis
|
0.010 |
Biomarker
|
disease |
BEFREE |
We investigated the role of GNMT in human HCC cell lines and in liver carcinogenesis in mice.
|
22687285 |
2012 |
|
Leukemia, Myelocytic, Acute
|
0.010 |
PosttranslationalModification
|
disease |
BEFREE |
Using the Illumina GoldenGate© methylation assay, we examined the methylation status of 1505 CpG-sites from 807 genes in 32 samples from patients with acute myeloid leukaemia (AML) at diagnosis, nine at relapse and 15 normal controls and performed additional pyrosequencing and semiquantitative methylation specific polymerase chain reaction (MSP) of the GNMT promoter in 113 diagnostic AML samples.
|
21790528 |
2011 |