Hypermethioninemia due to deficiency of glycine N-methyltransferase
|
0.900 |
Biomarker
|
disease |
CLINGEN |
Glycine N-Methyltransferase Deficiency: A Member of Dysmethylating Liver Disorders?
|
27207470 |
2017 |
Hypermethioninemia due to deficiency of glycine N-methyltransferase
|
0.900 |
Biomarker
|
disease |
MGD |
Characterization of a glycine N-methyltransferase gene knockout mouse model for hepatocellular carcinoma: Implications of the gender disparity in liver cancer susceptibility.
|
19035462 |
2009 |
Hypermethioninemia due to deficiency of glycine N-methyltransferase
|
0.900 |
GermlineCausalMutation
|
disease |
ORPHANET |
Inherited disorders in the conversion of methionine to homocysteine.
|
19585268 |
2009 |
Hypermethioninemia due to deficiency of glycine N-methyltransferase
|
0.900 |
Biomarker
|
disease |
CLINGEN |
Glycine N-methyltransferase-/- mice develop chronic hepatitis and glycogen storage disease in the liver.
|
17937387 |
2007 |
Hypermethioninemia due to deficiency of glycine N-methyltransferase
|
0.900 |
Biomarker
|
disease |
MGD |
Glycine N-methyltransferase-/- mice develop chronic hepatitis and glycogen storage disease in the liver.
|
17937387 |
2007 |
Hypermethioninemia due to deficiency of glycine N-methyltransferase
|
0.900 |
Biomarker
|
disease |
CLINGEN |
A glycine N-methyltransferase knockout mouse model for humans with deficiency of this enzyme.
|
16779654 |
2006 |
Hypermethioninemia due to deficiency of glycine N-methyltransferase
|
0.900 |
Biomarker
|
disease |
MGD |
A glycine N-methyltransferase knockout mouse model for humans with deficiency of this enzyme.
|
16779654 |
2006 |
Hypermethioninemia due to deficiency of glycine N-methyltransferase
|
0.900 |
Biomarker
|
disease |
CLINGEN |
Also discussed is the metabolic role of GNMT; several additional metabolite abnormalities found in these patients; and remaining questions about human GNMT deficiency, such as the long-term prognosis, whether other individuals with this defect are currently going undetected, and means to search for such persons.
|
14739680 |
2003 |
Hypermethioninemia due to deficiency of glycine N-methyltransferase
|
0.900 |
GeneticVariation
|
disease |
UNIPROT |
Also discussed is the metabolic role of GNMT; several additional metabolite abnormalities found in these patients; and remaining questions about human GNMT deficiency, such as the long-term prognosis, whether other individuals with this defect are currently going undetected, and means to search for such persons.
|
14739680 |
2003 |
Hypermethioninemia due to deficiency of glycine N-methyltransferase
|
0.900 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Also discussed is the metabolic role of GNMT; several additional metabolite abnormalities found in these patients; and remaining questions about human GNMT deficiency, such as the long-term prognosis, whether other individuals with this defect are currently going undetected, and means to search for such persons.
|
14739680 |
2003 |
Hypermethioninemia due to deficiency of glycine N-methyltransferase
|
0.900 |
GeneticVariation
|
disease |
UNIPROT |
Mutations in human glycine N-methyltransferase give insights into its role in methionine metabolism.
|
11810299 |
2002 |
Hypermethioninemia due to deficiency of glycine N-methyltransferase
|
0.900 |
Biomarker
|
disease |
CTD_human |
Mutations in human glycine N-methyltransferase give insights into its role in methionine metabolism.
|
11810299 |
2002 |
Hypermethioninemia due to deficiency of glycine N-methyltransferase
|
0.900 |
Biomarker
|
disease |
CLINGEN |
Glycine N-methyltransferase deficiency: a novel inborn error causing persistent isolated hypermethioninaemia.
|
11596649 |
2001 |
Hypermethioninemia due to deficiency of glycine N-methyltransferase
|
0.900 |
Biomarker
|
disease |
CTD_human |
Glycine N-methyltransferase deficiency: a novel inborn error causing persistent isolated hypermethioninaemia.
|
11596649 |
2001 |
Hypermethioninemia due to deficiency of glycine N-methyltransferase
|
0.900 |
Biomarker
|
disease |
CLINGEN |
Reduced mRNA abundance of the main enzymes involved in methionine metabolism in human liver cirrhosis and hepatocellular carcinoma.
|
11131452 |
2000 |
Hypermethioninemia due to deficiency of glycine N-methyltransferase
|
0.900 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
CTD_human |
Overall, our findings suggest that reduced Gnmt expression caused by promoter hypermethylation is one of the key molecular events in the development of NAFLD-derived HCC and that assessing Gnmt methylation level may be useful for disease stratification.
|
31086990 |
2019 |
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
The protective role of GNMT in the liver allows GNMT to not only serve as a marker of liver disease, but also potentially be applied in the treatment of liver disorders and hepatocellular carcinoma.
|
31170416 |
2019 |
Liver carcinoma
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
Recently, we identified 1,2,3,4,6-penta-O-galloyl-beta-D-glucopyranoside (PGG) as a GNMT promoter enhancer compound in HCC.
|
30760754 |
2019 |
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
The loss of liver glycine N-methyltransferase (GNMT) promotes liver steatosis and the transition to hepatocellular carcinoma (HCC).
|
30850319 |
2019 |
Liver carcinoma
|
0.600 |
PosttranslationalModification
|
disease |
BEFREE |
Overall, our findings suggest that reduced Gnmt expression caused by promoter hypermethylation is one of the key molecular events in the development of NAFLD-derived HCC and that assessing Gnmt methylation level may be useful for disease stratification.
|
31086990 |
2019 |
Liver carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
The levels of miR-224 and GNMT mRNA showed a significant inverse relationship in tumor specimens from HCC patients.
|
30115977 |
2018 |
Liver carcinoma
|
0.600 |
AlteredExpression
|
disease |
BEFREE |
GNMT downregulation leads to loss of liver function progressing to fibrosis, cirrhosis, and hepatocellular carcinoma.
|
30237481 |
2018 |
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
In this study, we investigated the activity of ectopic GNMT delivered using recombinant adeno-associated virus (AAV) gene therapy in mouse models of liver cirrhosis and HCC.
|
30217986 |
2018 |
Liver carcinoma
|
0.600 |
Biomarker
|
disease |
BEFREE |
These results reveal a novel mechanism in which GNMT participates in AKT signaling and HCC tumorigenesis by promoting HectH9-mediated PREX2 degradation.
|
28205209 |
2017 |