In conclusion, these findings indicated that knockdown of SRPX2 inhibits cell proliferation and metastasis, and promotes chemosensitivity in ESCC cells through the inactivation of Wnt/β-catenin signaling pathway.
<b>Introduction</b>: SRPX2 and RAB31 play important roles in tumorigenesis and metastasis; however, their prognostic value in pancreatic cancer remains unclear.
Moreover, high levels of SRPX2 expression in the PCa tissues were significantly associated with Gleason score (<i>P</i>=0.008), lymph node metastasis (<i>P</i>=0.009), and distant metastasis (<i>P</i>=0.021).
Taken together, these data demonstrated that knockdown of SRPX2 inhibits the proliferation and metastasis in human prostate cancer cells, partly through the PI3K/Akt/mTOR signaling pathway.
On analysis of the relations between gene expression and clinicopathological factors, SRPX2 expression correlated with tumor size and distant metastasis.