|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Exhaled breath condensate PGD2-MOX level was also significantly correlated with sputum tryptase levels and lower pulmonary function in patients with asthma.
|
30986547 |
2019 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
MC-released preformed mediators including chymase, tryptase, and histamine and de novo synthesized mediators such as PGD2, LTC4, and LTE4 in addition of cytokines mainly TGFβ1, TSLP, IL-33, IL-4, and IL-13 participate in pathogenesis of asthma.
|
30506113 |
2019 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
This explains the design of highly selective compounds with innate abilities to antagonize PGD2-CRTh2 interactions and prevent pro-inflammatory allergies such as rhinitis and uncontrolled asthma.
|
31538888 |
2019 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Increased PGD2 level in the airways might be a cause of the BSM hyperresponsiveness in asthma.
|
30161143 |
2018 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Compared with the polyposis only group, hydrogen peroxide consumption, glutathione S-transferase, vitamin E and malondialdehyde were lower in the asthma group.
|
29948268 |
2018 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Icariin is a promising therapeutic strategy for asthma, and PGD2 might be a new target for asthma therapy in OVA-induced and RSV-infected asthma model.
|
28669561 |
2018 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Do Glutathione S-Transferase Genes Modify the Link between Indoor Air Pollution and Asthma, Allergies, and Lung Function? A Systematic Review.
|
29557517 |
2018 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Gene expression analysis revealed that eosinophils from tissue and blood of patients with AERD display increased levels of hPGDS compared with asthmatic and control samples.
|
27423494 |
2016 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The Relationship Between Glutathione S-Transferase-P1 and Beta-2 Adrenoreceptor Genotypes with Asthmatic Patients in the Turkish Population.
|
27385593 |
2016 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Glutathione S-transferase (GSTs) enzymes play an important role in cellular protection against inflammation, and functional genetic polymorphisms in GST genes show a significant association with asthma and allergy risk.
|
24471578 |
2014 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Glutathione S transferase theta1 and mu1 gene polymorphisms and phenotypic expression of asthma in Egyptian children: a case-control study.
|
24559168 |
2014 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
In 108 smokers and never smokers with asthma and 45 healthy controls [smokers and never smokers], we measured urinary tetranor prostaglandin (PG)D2 (PGDM) and leukotriene (LT)E4 , induced sputum fluid LTB4 , LTE4 , PGD2 , and PGE2 , plasma secretory phospholipase A2 (sPLA2 ), and 11β prostaglandin F2α (11βPGF2α ), and, in a subgroup with severe asthma, airway leukocyte and epithelial cell mRNA expression levels of arachidonic acid metabolic enzymes.
|
24571371 |
2014 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
The glutathione S-transferase P1 Ile105Val polymorphism markedly modifies allergen-provoked airway inflammation in atopic asthmatics in vivo.
|
23600543 |
2013 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Previous studies assessing the association between glutathione S-transferase T1 (GSTT1) null genotype and asthma risk during childhood reported conflicting results.
|
23076538 |
2013 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
There are limited studies on the role of interaction between exposure to ambient air pollution and glutathione-S-transferase (GST) P1 on the risk of asthma/wheezing among children, which provided suggestive, but inconclusive results.
|
23357926 |
2013 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Impact of glutathione-S-transferase gene polymorphisms on enzyme activity, lung function and bronchial asthma susceptibility in Egyptian children.
|
22326267 |
2012 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
This study evaluated the effects of indoor incense burning and glutathione S-transferase (GST) genetic polymorphisms on asthma and wheeze.
|
21109554 |
2011 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
The protein levels of Gc, hemopexin, and haptoglobin-b were increased, whereas the a1- antitrypsin and glutathione S-transferase levels were decreased in subjects with asthma.
|
21169467 |
2011 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Recently, certain glutathione S-transferase genotypes (e.g. the GSTM1 null genotype) and N-acetyltransferase genotypes associated with slow acetylation phenotypes have been reported to be associated with diisocyanate asthma.
|
21325943 |
2011 |
|
Asthma
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Downregulation of glutathione S-transferase pi in asthma contributes to enhanced oxidative stress.
|
21570714 |
2011 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
The glutathione S-transferase enzymes (GSTs) play an important role in the detoxification of environmental tobacco smoke (ETS), which contributes to airway inflammation, a key component of asthma.
|
20858151 |
2010 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Glutathione-S-transferase (GST) enzymes, which play an important role in antioxidant defences, may therefore influence asthma risk.
|
20032267 |
2010 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
Glutathione S-transferase gene polymorphisms and air pollution as interactive risk factors for asthma in a multicentre Italian field study: A preliminary study.
|
20367187 |
2010 |
|
Asthma
|
0.100 |
GeneticVariation
|
disease |
BEFREE |
1.Previous studies have established that genetic alterations in glutathione S-transferase enzymes may change the ability of the airway to deal with toxic substances and increase the risk of asthma.
|
20374258 |
2010 |
|
Asthma
|
0.100 |
Biomarker
|
disease |
BEFREE |
Glutathione-S-transferase (GST) P1, GSTM1, exercise, ozone and asthma incidence in school children.
|
18988661 |
2009 |