Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Differential Methylation Levels in CpGs of the BIN1 Gene in Individuals With Alzheimer Disease.
|
31335457 |
2020 |
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In this case-control study, we aimed to investigate whether single nucleotide polymorphisms in the BIN1 (rs744373) and IL-6 (rs1800795) genes are associated with AD.
|
26733302 |
2016 |
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Altogether, five loci (rs6656401 at CR1, rs983392within MS4A6A, rs11218343 at SORL1, rs6733839 at BIN1, and APOE ε4) have been detected to be associated with one or a few established AD-related neuroimaging measures.
|
26732597 |
2017 |
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The bridging integrator 1 Gene rs7561528 polymorphism contributes to Alzheimer's disease susceptibility in East Asian and Caucasian populations.
|
28302384 |
2017 |
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our study verified the association between PICALM, BIN1, CLU, and MS4A4E variants and AD susceptibility in Han Chinese populations.
|
25452228 |
2016 |
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In a subsequent promoter analysis, we found the single nucleotide polymorphism rs744373 C-allele to be associated with high mRNA levels of bridging integrator 1 (BIN1)/Amphiphysin 2, i.e. a major component of the endocytotic machinery and located in a crucial genetic AD risk locus.
|
26631617 |
2016 |
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
We hypothesized that the Bin1 monoclonal antibody (mAb) could be used in the treatment of AD by lowering the levels of Tau in cell culture and animal models.
|
31211444 |
2019 |
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
We propose that BIN1 mediates AD risk by modulating Tau pathology.
|
23399914 |
2013 |
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genetic variation in BIN1 gene and Alzheimer's disease risk in Han Chinese individuals.
|
24582639 |
2014 |
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In the present study, nsSNPs in CLU, PICALM and BIN1 genes were screened for their functional impact on concerned proteins and their plausible role in Alzheimer disease (AD) susceptibility.
|
22960267 |
2013 |
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The increased proteome depth afforded by our TMT pipeline allowed us to identify and quantify a large number of alternatively spliced protein isoforms in brain, including AD risk factors such as BIN1, PICALM, PTK2B, and FERMT2.
|
30286791 |
2018 |
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
As a consequence, how BIN1 through its interaction with Tau affects AD risk is also still not determined.
|
28755476 |
2017 |
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Correlation of gene expression with well-established AD-related factors, such as α-, β-, and γ-secretase activities, brain amyloid-β42 levels, and cerebrospinal fluid biomarkers, revealed a positive correlation between β-secretase activity and the expression of TREM2 and BIN1.
|
25281018 |
2015 |
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Replication of BIN1 association with Alzheimer's disease and evaluation of genetic interactions.
|
21321396 |
2011 |
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
By contrast, genetic risk for Alzheimer disease (AD) was associated with worse item and associative memory, indicating adverse effects of APOE ε4 and a genetic risk score for AD (PICALM, BIN1, CLU) on episodic memory in general.
|
27647283 |
2017 |
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Post-mortem and in vitro studies suggest that BIN1-associated AD risk is mediated by increased tau pathology but whether rs744373 is associated with increased tau pathology in vivo is unknown.
|
30992433 |
2019 |
Alzheimer's Disease
|
0.500 |
AlteredExpression
|
disease |
BEFREE |
Predominant expression of Alzheimer's disease-associated BIN1 in mature oligodendrocytes and localization to white matter tracts.
|
27488240 |
2016 |
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our findings demonstrate that rs744373 itself or a variation in linkage disequilibrium may provide a neurogenetic mechanism for BIN1 while further validating the possibility of combining genetic and neuroimaging strategies to monitor individuals at risk for AD.
|
25630570 |
2015 |
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The direction of association at APOE, CLU, and BIN1 loci was the same for participants with PCA and posterior AD.
|
24670887 |
2014 |
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Bridging integrator 1 (BIN1): form, function, and Alzheimer's disease.
|
23871436 |
2013 |
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Bridging integrator 1 (BIN1) is considered as common genetic risk factors for AD, whereas different studies have provided various conclusions regarding its role in AD.
|
26768592 |
2017 |
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Common variants at Bin1 are associated with sporadic Alzheimer's disease in the Han Chinese population.
|
25461955 |
2015 |
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
The robust OL gene coexpression networks that we identified were highly enriched for genes associated with AD risk variants, such as BIN1 and demonstrated strong dysregulation in AD.
|
29110684 |
2017 |
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We found that the level of methylation at 71 of the 415,848 interrogated CpGs was significantly associated with the burden of AD pathology, including CpGs in the ABCA7 and BIN1 regions, which harbor known AD susceptibility variants.
|
25129075 |
2014 |
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genome-wide association studies and meta-analyses implicated that increased risk of developing Alzheimer's diseases (AD) has been associated with the ABCA7, APOE, BIN1, CASS4, CD2AP, CD33, CELF1, CLU, CR1, DSG2, EPHA1, FERMT2, HLA-DRB1, HLA-DRB4, INPP5D, MEF2C, MS4A4A, MS4A4E, MS4A6E, NME8, PICALM, PLD3, PTK2B, RIN3, SLC24A4, SORL1, and ZCWPW1 genes.
|
28199971 |
2017 |