|
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Replication of BIN1 association with Alzheimer's disease and evaluation of genetic interactions.
|
21321396 |
2011 |
|
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
CTD_human |
Common variants at MS4A4/MS4A6E, CD2AP, CD33 and EPHA1 are associated with late-onset Alzheimer's disease.
|
21460841 |
2011 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Recent genome-wide association studies of Alzheimer's disease (AD) have identified variants in BIN1, CLU, CR1 and PICALM that show replicable association with risk for disease.
|
21347408 |
2011 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In a total of 2816 AD cases and 2706 controls, we unambiguously replicated the association of rs744373 (for BIN1) and rs541458 (for PICALM) polymorphisms with the AD risk (odds ratio [OR] = 1.26, 95% confidence interval [CI] [1.15-1.38], p = 2.9 × 10(-7), and OR = 0.80, 95% CI [0.74-0.88], p = 4.6 × 10(-7), respectively).
|
21220176 |
2011 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
GWASCAT |
Genome-wide association study of Alzheimer's disease with psychotic symptoms.
|
22005930 |
2012 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
GWASDB |
Genome-wide association study of Alzheimer's disease with psychotic symptoms.
|
22005930 |
2012 |
|
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
We propose that BIN1 mediates AD risk by modulating Tau pathology.
|
23399914 |
2013 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In the present study, nsSNPs in CLU, PICALM and BIN1 genes were screened for their functional impact on concerned proteins and their plausible role in Alzheimer disease (AD) susceptibility.
|
22960267 |
2013 |
|
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Bridging integrator 1 (BIN1): form, function, and Alzheimer's disease.
|
23871436 |
2013 |
|
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
We identified rare small events overlapping CR1 and BIN1 in AD and normal controls with opposite CNV dosage.
|
23202439 |
2013 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
BIN1 gene rs744373 polymorphism contributes to Alzheimer's disease in East Asian population.
|
23570733 |
2013 |
|
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Several loci previously associated with Alzheimer disease but not reaching significance in genome-wide analyses were replicated in gene-based analyses accounting for linkage disequilibrium between markers and correcting for number of tests performed per gene (CR1, BIN1, EPHA1, CD33; 0.0005 < empirical P < .001).
|
23571587 |
2013 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Five genomewide association studies (GWAS) in white populations have recently identified and confirmed 9 novel Alzheimer's disease (AD) susceptibility loci (CLU, CR1, PICALM, BIN1, ABCA7, MS4A gene cluster, CD2AP, CD33, and EPHA1).
|
23232270 |
2013 |
|
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
After exclusion of loci already known to be involved in AD (APOE, BIN1 and CR1), 91 regions with suggestive haplotype effects were identified.
|
22430674 |
2013 |
|
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
These data suggest that the alteration in BIN1 is involved in the pathogenesis of sporadic, but not familial AD and is not a consequence of AD neurodegeneration or the ageing process, a finding in keeping with the numerous GWAS that implicate BIN1 in sporadic AD.
|
24205320 |
2013 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Genetic variation in BIN1 gene and Alzheimer's disease risk in Han Chinese individuals.
|
24582639 |
2014 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
The direction of association at APOE, CLU, and BIN1 loci was the same for participants with PCA and posterior AD.
|
24670887 |
2014 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
We found that the level of methylation at 71 of the 415,848 interrogated CpGs was significantly associated with the burden of AD pathology, including CpGs in the ABCA7 and BIN1 regions, which harbor known AD susceptibility variants.
|
25129075 |
2014 |
|
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
In addition, pooled analysis of our AD patients confirmed that CR1, TOMM40, BIN1, and CD33 contribute to late-onset AD susceptibility, in addition to apolipoprotein E.
|
24176626 |
2014 |
|
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Correlation of gene expression with well-established AD-related factors, such as α-, β-, and γ-secretase activities, brain amyloid-β42 levels, and cerebrospinal fluid biomarkers, revealed a positive correlation between β-secretase activity and the expression of TREM2 and BIN1.
|
25281018 |
2015 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our findings demonstrate that rs744373 itself or a variation in linkage disequilibrium may provide a neurogenetic mechanism for BIN1 while further validating the possibility of combining genetic and neuroimaging strategies to monitor individuals at risk for AD.
|
25630570 |
2015 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Common variants at Bin1 are associated with sporadic Alzheimer's disease in the Han Chinese population.
|
25461955 |
2015 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
Our results suggest that alterations in the BIN1 locus, previously associated with Alzheimer disease, may modify the AAO of GBA-associated PD.
|
26233692 |
2015 |
|
Alzheimer's Disease
|
0.500 |
Biomarker
|
disease |
BEFREE |
Brain DNA methylation in SORL1, ABCA7, HLA-DRB5, SLC24A4, and BIN1 was associated with pathological AD.
|
25365775 |
2015 |
|
Alzheimer's Disease
|
0.500 |
GeneticVariation
|
disease |
BEFREE |
In this case-control study, we aimed to investigate whether single nucleotide polymorphisms in the BIN1 (rs744373) and IL-6 (rs1800795) genes are associated with AD.
|
26733302 |
2016 |