|
Obesity
|
0.220 |
Biomarker
|
disease |
BEFREE |
Here we report that normal diet-fed Glrx-deficient mice (Glrx<sup>-/-</sup>) spontaneously develop obesity, hyperlipidemia, and hepatic steatosis by 8 months of age.
|
27958883 |
2017 |
|
Obesity
|
0.220 |
AlteredExpression
|
disease |
BEFREE |
We have observed distinct differences in the expression levels of Grx in pancreatic islets between obese, diabetic db mice and lean, non-diabetic controls.
|
28542222 |
2017 |
|
Obesity
|
0.220 |
Biomarker
|
disease |
RGD |
S-Glutathionylation of hepatic and visceral adipose proteins decreases in obese rats.
|
23404913 |
2013 |
|
Myocardial Reperfusion Injury
|
0.200 |
Biomarker
|
phenotype |
RGD |
Broccoli: a unique vegetable that protects mammalian hearts through the redox cycling of the thioredoxin superfamily.
|
18163565 |
2008 |
|
Diabetes Mellitus, Experimental
|
0.200 |
Biomarker
|
disease |
RGD |
Glutaredoxin regulates nuclear factor kappa-B and intercellular adhesion molecule in Müller cells: model of diabetic retinopathy.
|
17324929 |
2007 |
|
Transient Ischemic Attack
|
0.200 |
Biomarker
|
disease |
RGD |
Localization of glutaredoxin (thioltransferase) in the rat brain and possible functional implications during focal ischemia.
|
10329397 |
1999 |
|
Adolescent idiopathic scoliosis
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.
|
30019117 |
2018 |
|
SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
|
0.100 |
GeneticVariation
|
disease |
GWASCAT |
The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease.
|
30019117 |
2018 |
|
Parkinson Disease
|
0.040 |
Biomarker
|
disease |
BEFREE |
Increased GLRX copy number in PD patients was associated with earlier PD onset; and Grx1 levels correlated with levels of proinflammatory tumor necrosis factor-α in mouse and human brain samples.
|
29183158 |
2019 |
|
Parkinson Disease
|
0.040 |
Biomarker
|
disease |
BEFREE |
Increased GLRX copy number in PD patients was associated with earlier PD onset, and Grx1 levels correlated with levels of proinflammatory tumor necrosis factor-alpha (TNF-α) in mouse and human brain samples, prompting mechanistic in vitro studies.
|
27224303 |
2016 |
|
Parkinson Disease
|
0.040 |
GeneticVariation
|
disease |
BEFREE |
We subsequently investigated the potential role of Grx1 deficiency in PD pathogenesis by examining the consequences of loss of the Caenorhabditis elegans Grx1 homolog in well-established worm models of familial PD caused by overexpression of pathogenic human LRRK2 mutants G2019S or R1441C.
|
25355420 |
2015 |
|
Parkinson Disease
|
0.040 |
Biomarker
|
disease |
BEFREE |
Glutaredoxin 1 protects dopaminergic cells by increased protein glutathionylation in experimental Parkinson's disease.
|
22816731 |
2012 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Mouse tumor xenografts were used to assess the effect of GLRX in vivo.
|
30661098 |
2019 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
In our previous study, IL-1β was found to be one of the key node genes during oral malignant transformation, and glutaredoxin 1 (Grx1) was identified as one of the downstream genes of IL-1β in tumor microenvironment.
|
27658048 |
2017 |
|
Neoplasms
|
0.030 |
AlteredExpression
|
group |
BEFREE |
The contents of reduced glutathione and thioltransferase activity were significantly increased in tumor compared to non-tumor tissue.
|
28288548 |
2017 |
|
Lung diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
Dysregulation of the glutaredoxin/S-glutathionylation redox axis in lung diseases.
|
31693398 |
2020 |
|
Pulmonary Fibrosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Meanwhile, exogenous Glrx administration can reverse pathological lung fibrosis.
|
31813265 |
2020 |
|
Conotruncal defect
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
One SNP pair (i.e., rs4764267 and rs6556883) located in gene MGST1 and GLRX, respectively, was found to be associated with CTD risk after multiple testing adjustment using simpleM, a modified Bonferroni correction approach (nominal p-value of 4.62e-06; adjusted p-value of .04).
|
31851787 |
2020 |
|
Limb ischemia
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
Here, we examined the role of EC-specific Glrx up-regulation in distinct models of angiogenesis; namely, hind limb ischemia and tumor angiogenesis.
|
31647879 |
2019 |
|
Diabetes
|
0.020 |
Biomarker
|
disease |
BEFREE |
Furthermore, 61 bacterial gene clusters discriminated early and later stages of diabetes with elevations of enzymes related to stress response (e.g., glutathione and glutaredoxin) and amino acid, carbohydrate, and bacterial cell wall metabolism.
|
30016149 |
2018 |
|
Diabetes Mellitus
|
0.020 |
Biomarker
|
group |
BEFREE |
Furthermore, 61 bacterial gene clusters discriminated early and later stages of diabetes with elevations of enzymes related to stress response (e.g., glutathione and glutaredoxin) and amino acid, carbohydrate, and bacterial cell wall metabolism.
|
30016149 |
2018 |
|
Pulmonary Fibrosis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Collectively, these findings suggest the therapeutic potential of exogenous GLRX in treating lung fibrosis.
|
29988126 |
2018 |
|
Conotruncal defect
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The risk of CTHD among children who inherited a paternally derived copy of the A allele on GLRX (rs17085159) or the T allele of GLRX (rs12109442) was 0.23 (95%CI: 0.12, 0.42; p = 1.09 × 10<sup>-6</sup> ) and 0.27 (95%CI: 0.14, 0.50; p = 2.06 × 10<sup>-5</sup> ) times the risk among children who inherited a maternal copy of the same allele.
|
29399948 |
2018 |
|
Myeloid Leukemia, Chronic
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We demonstrate that sustained activation of STAT5 induced by Bcr-Abl in chronic myeloid leukemia (CML) cells promotes ROS production by repressing expression of two antioxidant enzymes, catalase and glutaredoxin-1(Glrx1).
|
27566554 |
2017 |
|
Diabetes
|
0.020 |
Biomarker
|
disease |
BEFREE |
Remarkably, upregulation of glutaredoxin-1 (Grx1) is implicated in regulation of inflammatory responses in various disease contexts, including diabetes.
|
27224303 |
2016 |