GMPR, guanosine monophosphate reductase, 2766

N. diseases: 18; N. variants: 27
Disease: Tumor Cell Invasion ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.020 Biomarker phenotype BEFREE Moreover, loss of GMPR accompanies downregulation of MITF in vemurafenib-resistant BRAF<sup>V600E</sup>-melanoma cells and underlies the increased invasion in these cells. 27181209 2017
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.020 Biomarker phenotype BEFREE Our data identify GMPR as a melanoma invasion suppressor and establish a link between guanosine metabolism and Rho-GTPase-dependent melanoma cell invasion. 24139804 2013