|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
These animals are also a source of pancreatic α-amylase inhibitors, which have the ability to control the glucose level in the blood and can be used for the treatment of prediabetes and type 2 diabetes mellitus.
|
31546678 |
2019 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.040 |
Biomarker
|
disease |
BEFREE |
The acylated flavonol glycoside montbretin A (MbA) and its precursor myricetin 3-<i>O</i>-(6'-<i>O</i>-caffeoyl)-glucosyl rhamnoside (mini-MbA) are potent inhibitors of human pancreatic α-amylase and are being developed as drug candidates to treat type-2 diabetes.
|
29967287 |
2018 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.040 |
Biomarker
|
disease |
BEFREE |
We found potent pancreatic α-amylase inhibition in Astilbe thunbergii root extract (AT) and confirmed that AT treatment in a T2DM rat model reduces post-starch administration blood glucose levels.
|
28743229 |
2017 |
|
Diabetes Mellitus, Non-Insulin-Dependent
|
0.040 |
Biomarker
|
disease |
BEFREE |
Structures of human pancreatic α-amylase in complex with acarviostatins: Implications for drug design against type II diabetes.
|
21111049 |
2011 |
|
Hyperglycemia
|
0.030 |
Biomarker
|
disease |
BEFREE |
Astilbe thunbergii reduces postprandial hyperglycemia in a type 2 diabetes rat model via pancreatic alpha-amylase inhibition by highly condensed procyanidins.
|
28743229 |
2017 |
|
Hyperglycemia
|
0.030 |
Biomarker
|
disease |
BEFREE |
In this study, the inhibitory effects of loquat leaf extract (LLE) on pancreatic α-amylase and α-glucosidase, and the preventative effects of LLE on hyperlipidemia and hyperglycemia in rats induced by a high fat and fructose diet have been evaluated.
|
28124052 |
2017 |
|
Hyperglycemia
|
0.030 |
AlteredExpression
|
disease |
BEFREE |
Intestinal and pancreatic α-amylase and α-glucosidase inhibitors offer an approach to lower the levels of post-prandial hyperglycemia through the control of dietary starch breakdown in digestion.
|
28170007 |
2017 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.020 |
Biomarker
|
disease |
BEFREE |
Seven out of 10 clones were amylase alpha-2A, the autoantibody to which was specifically detected in sera from patients with AIP and fulminant type 1 diabetes (FT1DM) [T. Endo, S. Takizawa, S. Tanaka, M. Takahashi, H. Fujii, T. Kamisawa, T. Kobayashi, Amylase alpha-2A autoantibodies: novel marker of autoimmune pancreatitis and fulminant type 1 diabetes mellitus, Diabetes 58 (2009) 732-737].
|
19520060 |
2009 |
|
Diabetes Mellitus, Insulin-Dependent
|
0.020 |
Biomarker
|
disease |
BEFREE |
These results suggest that an autoantibody against amylase alpha-2A is a novel diagnostic marker for both AIP and fulminant type 1 diabetes and that, clinically and immunologically, AIP and fulminant type 1 diabetes are closely related.
|
19001184 |
2009 |
|
Acute intermittent porphyria
|
0.020 |
Biomarker
|
disease |
BEFREE |
Seven out of 10 clones were amylase alpha-2A, the autoantibody to which was specifically detected in sera from patients with AIP and fulminant type 1 diabetes (FT1DM) [T. Endo, S. Takizawa, S. Tanaka, M. Takahashi, H. Fujii, T. Kamisawa, T. Kobayashi, Amylase alpha-2A autoantibodies: novel marker of autoimmune pancreatitis and fulminant type 1 diabetes mellitus, Diabetes 58 (2009) 732-737].
|
19520060 |
2009 |
|
Acute intermittent porphyria
|
0.020 |
Biomarker
|
disease |
BEFREE |
These results suggest that an autoantibody against amylase alpha-2A is a novel diagnostic marker for both AIP and fulminant type 1 diabetes and that, clinically and immunologically, AIP and fulminant type 1 diabetes are closely related.
|
19001184 |
2009 |
|
Acute interstitial pneumonia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Seven out of 10 clones were amylase alpha-2A, the autoantibody to which was specifically detected in sera from patients with AIP and fulminant type 1 diabetes (FT1DM) [T. Endo, S. Takizawa, S. Tanaka, M. Takahashi, H. Fujii, T. Kamisawa, T. Kobayashi, Amylase alpha-2A autoantibodies: novel marker of autoimmune pancreatitis and fulminant type 1 diabetes mellitus, Diabetes 58 (2009) 732-737].
|
19520060 |
2009 |
|
Acute interstitial pneumonia
|
0.020 |
Biomarker
|
disease |
BEFREE |
These results suggest that an autoantibody against amylase alpha-2A is a novel diagnostic marker for both AIP and fulminant type 1 diabetes and that, clinically and immunologically, AIP and fulminant type 1 diabetes are closely related.
|
19001184 |
2009 |
|
Autoimmune pancreatitis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Seven out of 10 clones were amylase alpha-2A, the autoantibody to which was specifically detected in sera from patients with AIP and fulminant type 1 diabetes (FT1DM) [T. Endo, S. Takizawa, S. Tanaka, M. Takahashi, H. Fujii, T. Kamisawa, T. Kobayashi, Amylase alpha-2A autoantibodies: novel marker of autoimmune pancreatitis and fulminant type 1 diabetes mellitus, Diabetes 58 (2009) 732-737].
|
19520060 |
2009 |
|
Autoimmune pancreatitis
|
0.020 |
Biomarker
|
disease |
BEFREE |
Amylase alpha-2A autoantibodies: novel marker of autoimmune pancreatitis and fulminant type 1 diabetes.
|
19001184 |
2009 |
|
Prediabetes syndrome
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
These animals are also a source of pancreatic α-amylase inhibitors, which have the ability to control the glucose level in the blood and can be used for the treatment of prediabetes and type 2 diabetes mellitus.
|
31546678 |
2019 |
|
Lafora Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
We report studies on the efficacy and CNS delivery of VAL-0417, an antibody-enzyme fusion composed of the 3E10 hFab and human pancreatic α-amylase, in a mouse model of LD.
|
31329461 |
2019 |
|
Hyperlipidemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
In this study, the inhibitory effects of loquat leaf extract (LLE) on pancreatic α-amylase and α-glucosidase, and the preventative effects of LLE on hyperlipidemia and hyperglycemia in rats induced by a high fat and fructose diet have been evaluated.
|
28124052 |
2017 |
|
Obesity
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Obesity, starch digestion and amylase: association between copy number variants at human salivary (AMY1) and pancreatic (AMY2) amylase genes.
|
25788522 |
2015 |
|
Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
A 30 Kb HD of the 1p21.1 chromosomal region was shown to contain a potential candidate tumor-suppressor gene (TSG) of AMY2A.
|
20428766 |
2010 |
|
Stomach Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
We demonstrated that AMY2A, a possible TSG, is frequently silenced in GC deletion 1p21.1.
|
20428766 |
2010 |
|
Diabetes
|
0.010 |
Biomarker
|
disease |
BEFREE |
Seven out of 10 clones were amylase alpha-2A, the autoantibody to which was specifically detected in sera from patients with AIP and fulminant type 1 diabetes (FT1DM) [T. Endo, S. Takizawa, S. Tanaka, M. Takahashi, H. Fujii, T. Kamisawa, T. Kobayashi, Amylase alpha-2A autoantibodies: novel marker of autoimmune pancreatitis and fulminant type 1 diabetes mellitus, Diabetes 58 (2009) 732-737].
|
19520060 |
2009 |
|
Diabetes Mellitus
|
0.010 |
Biomarker
|
group |
BEFREE |
Seven out of 10 clones were amylase alpha-2A, the autoantibody to which was specifically detected in sera from patients with AIP and fulminant type 1 diabetes (FT1DM) [T. Endo, S. Takizawa, S. Tanaka, M. Takahashi, H. Fujii, T. Kamisawa, T. Kobayashi, Amylase alpha-2A autoantibodies: novel marker of autoimmune pancreatitis and fulminant type 1 diabetes mellitus, Diabetes 58 (2009) 732-737].
|
19520060 |
2009 |
|
Pancreatitis
|
0.010 |
Biomarker
|
disease |
LHGDN |
Amylase alpha-2A autoantibodies: novel marker of autoimmune pancreatitis and fulminant type 1 diabetes.
|
19001184 |
2009 |
|
Fulminant type 1 diabetes mellitus
|
0.010 |
Biomarker
|
disease |
BEFREE |
Seven out of 10 clones were amylase alpha-2A, the autoantibody to which was specifically detected in sera from patients with AIP and fulminant type 1 diabetes (FT1DM) [T. Endo, S. Takizawa, S. Tanaka, M. Takahashi, H. Fujii, T. Kamisawa, T. Kobayashi, Amylase alpha-2A autoantibodies: novel marker of autoimmune pancreatitis and fulminant type 1 diabetes mellitus, Diabetes 58 (2009) 732-737].
|
19520060 |
2009 |