GOT1, glutamic-oxaloacetic transaminase 1, 2805

N. diseases: 71; N. variants: 4
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0019193
Disease: Hepatitis, Toxic
Hepatitis, Toxic
0.300 Biomarker disease CTD_human Characterization of chemically induced liver injuries using gene co-expression modules. 25226513 2014
CUI: C0860207
Disease: Drug-Induced Liver Disease
Drug-Induced Liver Disease
0.300 Biomarker phenotype CTD_human Characterization of chemically induced liver injuries using gene co-expression modules. 25226513 2014
CUI: C1262760
Disease: Hepatitis, Drug-Induced
Hepatitis, Drug-Induced
0.300 Biomarker disease CTD_human Characterization of chemically induced liver injuries using gene co-expression modules. 25226513 2014
CUI: C3658290
Disease: Drug-Induced Acute Liver Injury
Drug-Induced Acute Liver Injury
0.300 Biomarker disease CTD_human Characterization of chemically induced liver injuries using gene co-expression modules. 25226513 2014
Chemical and Drug Induced Liver Injury
0.300 Biomarker disease CTD_human Characterization of chemically induced liver injuries using gene co-expression modules. 25226513 2014
CUI: C4279912
Disease: Chemically-Induced Liver Toxicity
Chemically-Induced Liver Toxicity
0.300 Biomarker disease CTD_human Characterization of chemically induced liver injuries using gene co-expression modules. 25226513 2014
CUI: C0023893
Disease: Liver Cirrhosis, Experimental
Liver Cirrhosis, Experimental
0.300 Biomarker disease CTD_human Gene expression profiles of hepatic cell-type specific marker genes in progression of liver fibrosis. 17072980 2006
CUI: C0242488
Disease: Acute Lung Injury
Acute Lung Injury
0.200 Biomarker disease RGD Endogeous sulfur dioxide protects against oleic acid-induced acute lung injury in association with inhibition of oxidative stress in rats. 25581610 2015
CUI: C0009952
Disease: Febrile Convulsions
Febrile Convulsions
0.200 Biomarker disease RGD Dose-dependent effect of sulfur dioxide on brain damage induced by recurrent febrile seizures in rats. 24373994 2014
CUI: C0033141
Disease: Cardiomyopathies, Primary
Cardiomyopathies, Primary
0.200 Biomarker group RGD Endogenous sulfur dioxide protects against isoproterenol-induced myocardial injury and increases myocardial antioxidant capacity in rats. 20733562 2011
CUI: C0036529
Disease: Myocardial Diseases, Secondary
Myocardial Diseases, Secondary
0.200 Biomarker group RGD Endogenous sulfur dioxide protects against isoproterenol-induced myocardial injury and increases myocardial antioxidant capacity in rats. 20733562 2011
CUI: C0878544
Disease: Cardiomyopathies
Cardiomyopathies
0.200 Biomarker group RGD Endogenous sulfur dioxide protects against isoproterenol-induced myocardial injury and increases myocardial antioxidant capacity in rats. 20733562 2011
CUI: C0007787
Disease: Transient Ischemic Attack
Transient Ischemic Attack
0.200 Therapeutic disease RGD Oxygen-sensitive outcomes and gene expression in acute ischemic stroke. 20145654 2010
CUI: C0242706
Disease: Hyperoxia
Hyperoxia
0.200 Biomarker phenotype RGD Time-dependent alterations of cerebral proteins following short-term normobaric hyperoxia. 20049628 2010
Aspartate aminotransferase measurement
0.100 GeneticVariation phenotype GWASCAT The Korea Biobank Array: Design and Identification of Coding Variants Associated with Blood Biochemical Traits. 30718733 2019
CUI: C0410702
Disease: Adolescent idiopathic scoliosis
Adolescent idiopathic scoliosis
0.100 GeneticVariation disease GWASCAT The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease. 30019117 2018
SCOLIOSIS, ISOLATED, SUSCEPTIBILITY TO, 3
0.100 GeneticVariation disease GWASCAT The coexistence of copy number variations (CNVs) and single nucleotide polymorphisms (SNPs) at a locus can result in distorted calculations of the significance in associating SNPs to disease. 30019117 2018
CUI: C1704436
Disease: Peripheral Arterial Diseases
Peripheral Arterial Diseases
0.100 GeneticVariation group GWASCAT Genetic Variants in the Bone Morphogenic Protein Gene Family Modify the Association between Residential Exposure to Traffic and Peripheral Arterial Disease. 27082954 2016
Aspartate aminotransferase measurement
0.100 GeneticVariation phenotype GWASCAT Genome-wide association study of liver enzymes in korean children. 24124411 2013
CORONARY ARTERY DISEASE, AUTOSOMAL DOMINANT, 1
0.100 GeneticVariation disease GWASDB Large-scale association analysis identifies new risk loci for coronary artery disease. 23202125 2013
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.070 Biomarker group BEFREE The screening revealed that inhibitors of Hsp90 can potentiate the tumour cell-killing effect of radiation in a synergistic fashion (GOT1; false discovery rate <3.2×10-11). 30730850 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.070 Biomarker group BEFREE Previous studies on nude mice bearing the human small intestine neuroendocrine tumor, GOT1, have shown that a priming injection of <sup>177</sup>Lu-octreotate 24 h before the main injection of <sup>177</sup>Lu-octreotate resulted in higher <sup>177</sup>Lu concentration in tumor, resulting in increased absorbed dose, volume reduction, and time to regrowth. 30895393 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.070 AlteredExpression group BEFREE Furthermore, downregulation of GOT1 counteracted the effects of miR-9-5p repression, whereas its overexpression reversed tumor inhibitory effects of miR-9-5p. 30591220 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.070 Biomarker group BEFREE The HDM2 (MDM2) Inhibitor NVP-CGM097 Inhibits Tumor Cell Proliferation and Shows Additive Effects with 5-Fluorouracil on the p53-p21-Rb-E2F1 Cascade in the p53wild type Neuroendocrine Tumor Cell Line GOT1. 27871087 2018
CUI: C0027651
Disease: Neoplasms
Neoplasms
0.070 AlteredExpression group BEFREE <i>CCAT-1</i> expression was related to the stage and size of the tumor and recurrence prognosis. 28978096 2017