GPD2, glycerol-3-phosphate dehydrogenase 2, 2820

N. diseases: 38; N. variants: 5
Disease: Malignant Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.020 Biomarker group BEFREE However, the upregulation of miR-1 in cancer non-stem cells did not induce mitochondrial damage. miR-1 overexpression caused mitochondrial damage of cancer stem cells by directly targeting the 3' UTRs of MINOS1 (mitochondrial inner membrane organizing system 1) and GPD2 (glycerol-3-phosphate dehydrogenase 2) genes and interacting with LRPPRC (leucine-rich pentatricopeptide-repeat containing) protein, a protein localized in mitochondria. 31765945 2019
CUI: C0006826
Disease: Malignant Neoplasms
Malignant Neoplasms 		0.020 Biomarker group BEFREE We demonstrate that MGPDH regulates human thyroid cancer cell growth and OXPHOS rate <i>in vitro</i> Metformin treatment is associated with downregulation of MGPDH expression and inhibition of OXPHOS in thyroid cancer <i>in vitro</i> Cells characterized by high MGPDH expression are more sensitive to OXPHOS-inhibitory effects of metformin <i>in vitro</i> and growth-inhibitory effects of metformin <i>in vitro</i> and <i>in vivo</i><b>Conclusions:</b> Our study established MGPDH as a novel regulator of thyroid cancer growth and metabolism that can be effectively targeted by metformin.<i>Clin Cancer Res; 24(16); 4030-43.©2018 AACR</i>. 29691295 2018