|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
GPAA1 facilitates the expression of cancer-related GPI-anchored proteins and supplies a more robust platform-the lipid raft-to promote EGFR-ERBB2 dimerization, which further contributes to tumour growth and metastasis and to cancer progression.
|
31118109 |
2019 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Autocrine motility factor (AMF) is a tumor-secreted cytokine that stimulates tumor cell motility in vitro and metastasis in vivo.
|
28500945 |
2017 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Here, we discuss the benefits and limitations of disrupting fermentative glycolysis for impeding tumor growth at three levels of the pathway: (i) an upstream block at the level of the glucose-6-phosphate isomerase (GPI), (ii) a downstream block at the level of lactate dehydrogenases (LDH, isoforms A and B), and (iii) the endpoint block preventing lactic acid export (MCT1/4).
|
29326883 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
AMF is known to stimulate proliferation, survival and metastasis of cancer cells, and angiogenesis within a tumor.
|
28599497 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Disrupting glucose-6-phosphate isomerase fully suppresses the "Warburg effect" and activates OXPHOS with minimal impact on tumor growth except in hypoxia.
|
29152106 |
2017 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Phosphoglucose isomerase/autocrine motility factor (PGI/AMF) is secreted by tumors and influences tumor growth and metastasis.
|
26936801 |
2016 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Mice treated with TA-CIN/GPI-0100 vaccination exhibited robust E7-specific CD8+ T cell responses, which were associated with reduced tumor burden in the lung, whereas mice receiving either component alone were similar to controls.
|
25560237 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Autocrine motility factor (AMF), which is also known as phosphoglucose isomerase (PGI), enhances tumor cell growth and motility.
|
26308071 |
2015 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Taken together, our findings show how AMF modulates EGF-induced invasion while affecting acquired resistance to cytotoxic drugs in the tumor microenvironment.
|
24576828 |
2014 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The expression of AMF is associated with metastasis in malignant musculoskeletal tumors including osteosarcoma.
|
23027359 |
2012 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Because GPC3 binds with high affinity to Wnts, and its growth-promoting activity requires attachment to the cell membrane, we have hypothesized that a mutated GPC3 lacking the GPI anchoring domain (sGPC3) will block Wnt signaling and inhibit the growth of Wnt-dependent tumors.
|
19816934 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Phosphoglucose isomerase (PGI) is a multifunctional enzyme that functions in glucose metabolism as a glycolytic enzyme catalyzing an interconversion between glucose and fructose inside the cell, while it acts as cytokine outside the cell, with properties that include autocrine motility factor (AMF)-regulating tumor cell motility.
|
20978190 |
2010 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Mammalian PGI is a multi-functional protein which, besides its glycolytic function, can also act as a cytokine, growth factor and inducer of angiogenesis, and plays a role in tumour growth, development and metastasis formation.
|
20600070 |
2010 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We used an orthotopic mouse tumor model to assess whether overexpression of PGI enhances liver metastasis.
|
19787266 |
2009 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Furthermore, tumor cells with PGI/AMF deficiency lost their abilities to form tumor mass.
|
17483335 |
2007 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Phosphoglucose isomerase/autocrine motility factor (PGI/AMF) is a housekeeping gene product present in all cells, is an essential enzyme of catabolic glycolysis and anabolic gluconeogenesis, and regulates tumor cell growth and metastasis.
|
17925402 |
2007 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
Both AMF and AMFR transcripts were significantly higher in tumor than in normal tissues (p=0.003 and p=0.0001, respectively).
|
16204225 |
2006 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
The results presented here suggest that under hypoxic conditions the expression of PGI/AMF is regulated in part by the HIF pathway, which in turn increases the flow of the glycolytic cascade leading to an increased anaerobic energy generation; thus, inhibition of PGI/AMF expression and activities may provide a new therapeutic modality for treatment of hypoxic tumors.
|
16126909 |
2005 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
It is well known that expression levels of AMF secretion and its receptor (AMF R) are closely related to tumor malignancy and rheumatoid arthritis.
|
14566819 |
2003 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
We conclude that the presence of higher AMF-R gene expression and tumor cell motility via receptor in response to the stimulation of AMF could be an important aspect in the invasion and metastasis of lung cancer cell lines.
|
11748469 |
2002 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
In human ovarian cancer cell lines, GPI-PLD mRNA expression correlated with GPI-PLD enzyme activity and with the shedding of the GPI-anchored tumor and prognostic markers, urokinase receptor and CA125, from the cell surface.
|
12090469 |
2002 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
It is suggested that AMF is one of the significant factors which relates to various pathological malignancies induced by tumor mass, and understanding of its function could benefit prognosis and treatment.
|
12054583 |
2002 |
|
Neoplasms
|
0.100 |
AlteredExpression
|
group |
BEFREE |
In contrast, overexpression of GPI-uPAR in tumor cells did not affect tumor growth.
|
11517932 |
2001 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
Purification of human tumor cell autocrine motility factor and molecular cloning of its receptor.
|
1649192 |
1991 |
|
Neoplasms
|
0.100 |
Biomarker
|
group |
BEFREE |
We have isolated a tumor cell autocrine motility factor (AMF).
|
2851925 |
1988 |