|
Alzheimer's Disease
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
GPR3 is expressed in the central nervous system (CNS) and is known to be related to Alzheimer's disease and other CNS diseases.
|
31516076 |
2020 |
|
Alzheimer's Disease
|
0.050 |
AlteredExpression
|
disease |
BEFREE |
Taken together, these results suggest an important role of the allosteric sodium binding site for GPR3 activity and open a possible avenue for the modulation of Aβ production in the Alzheimer's Disease.
|
30038319 |
2018 |
|
Alzheimer's Disease
|
0.050 |
Biomarker
|
disease |
BEFREE |
GPR3 represents a possible target for the treatment of different pathological conditions such as Alzheimer's disease, oocyte maturation, or neuropathic pain.
|
28750813 |
2017 |
|
Alzheimer's Disease
|
0.050 |
Biomarker
|
disease |
BEFREE |
Previously, it has been reported that GPR3 is involved in Alzheimer's disease whereas GPR6 plays potential roles in Parkinson's disease.
|
28571738 |
2017 |
|
Alzheimer's Disease
|
0.050 |
Biomarker
|
disease |
BEFREE |
Two GPCRs implicated previously in Alzheimer's disease (GPR3 and the β(2)-adrenergic receptor) mediate their effects on Aβ generation through interaction with β-arrestin 2. β-arrestin 2 physically associates with the Aph-1a subunit of the γ-secretase complex and redistributes the complex toward detergent-resistant membranes, increasing the catalytic activity of the complex.
|
23202293 |
2013 |
|
Ovarian Failure, Premature
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
A haplotype-based analysis of seven polymorphisms of the microRNA machinery genes for gene-gene interactions suggests that ***ACTA, ***GCCA, ***G*C*, *T*ATTA, and ***ACT* haplotypes (asterisk indicates SNP locus not included; DROSHA rs6877842 and rs10719, DICER1 rs13078 and rs3742330, RAN rs14035, and XPO5 rs2257082 and rs11077 polymorphisms) are associated with higher POI prevalence, and that ***GCTA, ***ACCA, *C*ATTA, and *C*ATT* haplotypes are associated with lower POI prevalence.
|
23549446 |
2013 |
|
Ovarian Failure, Premature
|
0.030 |
GeneticVariation
|
disease |
BEFREE |
The results of this study suggested that mutations in GPR3 are not a common cause of POF in Chinese women.
|
20158988 |
2010 |
|
Ovarian Failure, Premature
|
0.030 |
Biomarker
|
disease |
BEFREE |
We conclude that perturbations in GPR3 are not a common explanation for POF in this population.
|
17953967 |
2008 |
|
Inflammatory Bowel Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
The anti-glycan antibodies: anti-laminaribioside, anti-chitobioside, and anti-mannobioside carbohydrate antibodies (ALCA, ACCA, and AMCA) are serological markers previously associated with IBD.
|
29998822 |
2019 |
|
Inflammatory Bowel Diseases
|
0.020 |
Biomarker
|
group |
BEFREE |
DNA testing and established (ASCA and pANCA) and emerging (ACCA, ALCA, AMCA, OmpC) serum markers are described; a further aspect to be addressed is the clinical use of pharmacogenetics for the treatment of IBDs.
|
24108210 |
2014 |
|
Premature Menopause
|
0.020 |
GeneticVariation
|
disease |
BEFREE |
The results of this study suggested that mutations in GPR3 are not a common cause of POF in Chinese women.
|
20158988 |
2010 |
|
Premature Menopause
|
0.020 |
Biomarker
|
disease |
BEFREE |
We conclude that perturbations in GPR3 are not a common explanation for POF in this population.
|
17953967 |
2008 |
|
CNS disorder
|
0.010 |
AlteredExpression
|
group |
BEFREE |
GPR3 is expressed in the central nervous system (CNS) and is known to be related to Alzheimer's disease and other CNS diseases.
|
31516076 |
2020 |
|
Rheumatoid Arthritis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Significantly higher levels of ACCA were observed in RA patients, compared to healthy controls (p=0.002).
|
29998822 |
2019 |
|
ST segment elevation myocardial infarction
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Background and design of the ACCA-EAPCI registry on ST-segment elevation myocardial infarction of the European Society of Cardiology.
|
29480015 |
2019 |
|
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
These results suggest that ACCA-substituted Ang-(1-7) analogues which show resistance against proteolytic degradation by peptidases known to hydrolyze the native heptapeptide may be novel therapeutics in the treatment of cancer.
|
28744580 |
2017 |
|
Neuralgia
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
GPR3 represents a possible target for the treatment of different pathological conditions such as Alzheimer's disease, oocyte maturation, or neuropathic pain.
|
28750813 |
2017 |
|
Parkinson Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Previously, it has been reported that GPR3 is involved in Alzheimer's disease whereas GPR6 plays potential roles in Parkinson's disease.
|
28571738 |
2017 |
|
Infection by Trichuris trichiura
|
0.010 |
Biomarker
|
disease |
BEFREE |
In contrast, a positive association was observed between the haplotype ACCA and Trichuris trichiura infection (OR, 1.85; P = .003) and Ascaris lumbricoides infection (OR, 2.01; P < .001).
|
28284979 |
2017 |
|
Acute myocardial infarction
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Performance of hospitals according to the ESC ACCA quality indicators and 30-day mortality for acute myocardial infarction: national cohort study using the United Kingdom Myocardial Ischaemia National Audit Project (MINAP) register.
|
28329279 |
2017 |
|
Primary malignant neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
These results suggest that ACCA-substituted Ang-(1-7) analogues which show resistance against proteolytic degradation by peptidases known to hydrolyze the native heptapeptide may be novel therapeutics in the treatment of cancer.
|
28744580 |
2017 |
|
Infection by Ascaris lumbricoides
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
In contrast, a positive association was observed between the haplotype ACCA and Trichuris trichiura infection (OR, 1.85; P = .003) and Ascaris lumbricoides infection (OR, 2.01; P < .001).
|
28284979 |
2017 |
|
Huntington Disease
|
0.010 |
Biomarker
|
disease |
BEFREE |
Neuron-specific mapping of the genome-wide distribution of H3K4me3 revealed 136 differentially enriched loci associated with genes implicated in neuronal development and neurodegeneration, including GPR3, TMEM106B, PDIA6 and the Notch signaling genes hairy and enhancer of split 4 (HES4) and JAGGED2, supporting the view that the neuronal epigenome is affected in HD.
|
25480889 |
2015 |
|
Polycystic Ovary Syndrome
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Further, the two haplotypes, ACCA and ACTA, were found to be significantly associated with PCOS indicating haplotype specific risk.
|
26458343 |
2015 |
|
Crohn Disease
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Such associations were not significant for ACCA levels in both subgroups of CD probands and of HFDRs.
|
23506543 |
2013 |