Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C4014762
Disease: MYOPIA 24, AUTOSOMAL DOMINANT
MYOPIA 24, AUTOSOMAL DOMINANT 		0.600 GeneticVariation disease UNIPROT SLC39A5 mutations interfering with the BMP/TGF-β pathway in non-syndromic high myopia. 24891338 2014
CUI: C4014762
Disease: MYOPIA 24, AUTOSOMAL DOMINANT
MYOPIA 24, AUTOSOMAL DOMINANT 		0.600 GeneticVariation disease UNIPROT Detection of mutations in LRPAP1, CTSH, LEPREL1, ZNF644, SLC39A5, and SCO2 in 298 families with early-onset high myopia by exome sequencing. 25525168 2014
CUI: C4014762
Disease: MYOPIA 24, AUTOSOMAL DOMINANT
MYOPIA 24, AUTOSOMAL DOMINANT 		0.600 Biomarker disease CTD_human
CUI: C4014762
Disease: MYOPIA 24, AUTOSOMAL DOMINANT
MYOPIA 24, AUTOSOMAL DOMINANT 		0.600 CausalMutation disease CLINVAR
CUI: C0027092
Disease: Myopia
Myopia 		0.100 Biomarker disease HPO
CUI: C0014859
Disease: Esophageal Neoplasms
Esophageal Neoplasms 		0.020 AlteredExpression group BEFREE Collectively, these findings indicate that knocking down ZIP5 by small interfering RNA (siRNA) might be a novel treatment strategy for esophageal cancer with ZIP5 overexpression. 27458102 2016
CUI: C0152018
Disease: Esophageal carcinoma
Esophageal carcinoma 		0.020 AlteredExpression disease BEFREE Collectively, these findings indicate that knocking down ZIP5 by small interfering RNA (siRNA) might be a novel treatment strategy for esophageal cancer with ZIP5 overexpression. 27458102 2016
CUI: C0546837
Disease: Malignant neoplasm of esophagus
Malignant neoplasm of esophagus 		0.020 AlteredExpression disease BEFREE Collectively, these findings indicate that knocking down ZIP5 by small interfering RNA (siRNA) might be a novel treatment strategy for esophageal cancer with ZIP5 overexpression. 27458102 2016
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.020 AlteredExpression phenotype BEFREE Downregulation of ZIP5 inhibited the proliferation, migration, and invasion of the esophageal cancer cell line KYSE170 in vitro. 27458102 2016
CUI: C0014859
Disease: Esophageal Neoplasms
Esophageal Neoplasms 		0.020 Biomarker group BEFREE Studies suggest that ZIP5 is differentially expressed during esophageal tumorigenesis, yet the role of ZIP5 in esophageal cancer cells has not yet been clarified. 26133979 2015
CUI: C0152018
Disease: Esophageal carcinoma
Esophageal carcinoma 		0.020 Biomarker disease BEFREE Studies suggest that ZIP5 is differentially expressed during esophageal tumorigenesis, yet the role of ZIP5 in esophageal cancer cells has not yet been clarified. 26133979 2015
CUI: C0546837
Disease: Malignant neoplasm of esophagus
Malignant neoplasm of esophagus 		0.020 Biomarker disease BEFREE Studies suggest that ZIP5 is differentially expressed during esophageal tumorigenesis, yet the role of ZIP5 in esophageal cancer cells has not yet been clarified. 26133979 2015
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.020 Biomarker phenotype BEFREE We conducted MTT and CCK-8 assays to determine the role of ZIP5 in cell proliferation, Transwell assays to detect migration and invasion, and flow cytometry (FCM) to detect apoptosis and cell cycle percentage using KYSE170K cells. 26133979 2015
CUI: C0178874
Disease: Tumor Progression
Tumor Progression 		0.010 Biomarker phenotype BEFREE The topological analysis of the network reveals that top out-degree genes such as SLC39A5 which are considered central genes, play important role in cancer progression. 29994618 2020
CUI: C0240066
Disease: Iron deficiency
Iron deficiency 		0.010 Biomarker disease BEFREE Moreover, combined with quantitative real-time PCR, IRT1, NRAMP3, NRAMP5, OPT3, YSL3, ABCC3, ZIP1, and ZIP5 were verified to be responsible for Cd uptake and translocation in peanut plants under iron deficiency. 30665365 2019
CUI: C0948379
Disease: Impaired insulin secretion
Impaired insulin secretion 		0.010 Biomarker disease BEFREE Moreover, β-cell-specific Slc39a5 knockout mice have impaired insulin secretion. 30324491 2019
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.010 Biomarker group BEFREE In this study, we found that downregulation of SLC39A5 (ZIP5) by interference resulted in a significant reduction in esophageal cancer tumor volume and weight in vivo. 27458102 2016
CUI: C0079731
Disease: B-Cell Lymphomas
B-Cell Lymphomas 		0.010 AlteredExpression group BEFREE However, we did not find that the downregulation of ZIP5 caused a change in the relative expressions of cyclin D1, VEGF (vascular endothelial growth factor), MMP9 (matrix metalloprotein 9), and Bcl-2 (B-cell lymphoma/leukmia-2) mRNA or an alteration in the average level of zinc in the peripheral blood and xenografts in vivo. 27458102 2016
CUI: C0279626
Disease: Squamous cell carcinoma of esophagus
Squamous cell carcinoma of esophagus 		0.010 AlteredExpression disease BEFREE The results demonstrated that ZIP5 protein and mRNA expression was highest in ESCC, intermediate in para-carcinoma and lowest in normal tissue. 26133979 2015
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.010 AlteredExpression phenotype BEFREE Studies suggest that ZIP5 is differentially expressed during esophageal tumorigenesis, yet the role of ZIP5 in esophageal cancer cells has not yet been clarified. 26133979 2015
CUI: C0271183
Disease: Severe myopia
Severe myopia 		0.010 GeneticVariation disease BEFREE We identified a nonsense mutation (c.141C>G:p.Y47*) in SLC39A5 co-segregating with the phenotype in a non-syndromic severe high myopia family. 24891338 2014