|
Diphtheria
|
0.020 |
Biomarker
|
disease |
BEFREE |
We used a murine orthotopic mammary tumor model, as well as Clec9A-diphtheria toxin receptor mice that can be depleted of the specialized cross-presenting CD8α<sup>+</sup> and CD103<sup>+</sup> DC1 subsets, to investigate the role of these DCs in immunotherapy.
|
29507107 |
2018 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
Clec9A-TNE encapsulating HPV E6/E7 significantly suppressed HPV-associated tumor growth, while E6/E7-CpG did not.
|
29485973 |
2018 |
|
Neoplasms
|
0.020 |
Biomarker
|
group |
BEFREE |
DC, NK lectin group receptor-1 (DNGR-1), also known as C-type lectin domain family 9 member A (CLEC9A), is a promising target for immunological therapeutics and vaccination against tumors and viruses.
|
28511091 |
2017 |
|
Diphtheria
|
0.020 |
Biomarker
|
disease |
BEFREE |
To begin to dissect the roles of different dendritic cell (DC) subsets in Plasmodium-induced pathology, we have generated a transgenic strain, Clec9A-diphtheria toxin receptor that allows us to ablate in vivo Clec9A(+) DCs.
|
22732587 |
2012 |
|
Enterovirus Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
Targeting of antigens to the dendritic cell (DC) molecule Clec9A has been shown to enhance antibody affinity and titers for model antigens, and influenza and enterovirus antigens, and may be advantageous for immunogens that otherwise fail to elicit antibodies with sufficient titers and breadth for broad protection, such as the envelope protein (Env) of HIV.
|
31430333 |
2019 |
|
Influenza
|
0.010 |
Biomarker
|
disease |
BEFREE |
Targeting of antigens to the dendritic cell (DC) molecule Clec9A has been shown to enhance antibody affinity and titers for model antigens, and influenza and enterovirus antigens, and may be advantageous for immunogens that otherwise fail to elicit antibodies with sufficient titers and breadth for broad protection, such as the envelope protein (Env) of HIV.
|
31430333 |
2019 |
|
Solid Neoplasm
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Thus, Clec9a-TNE codelivery of CD8<sup>+</sup> T-cell epitopes with αGC induces alternative helper signals from activated iNKT cells, elicits innate (iNKT, NK) immunity, and enhances antitumor CD8<sup>+</sup> T-cell responses for control of solid tumors.
|
31053598 |
2019 |
|
Pancreatitis, Acute Necrotizing
|
0.010 |
Biomarker
|
disease |
BEFREE |
DNGR-1 deficiency leads to exacerbated caerulein-induced necrotizing pancreatitis and increased pathology during systemic <i>Candida albicans</i> infection without affecting fungal burden.
|
30337411 |
2018 |
|
Neutrophilia (disorder)
|
0.010 |
Biomarker
|
disease |
BEFREE |
This effect is B and T cell-independent and attributable to increased neutrophilia in DNGR-1-deficient settings.
|
30337411 |
2018 |
|
Acquired Immunodeficiency Syndrome
|
0.010 |
AlteredExpression
|
group |
BEFREE |
DNGR-1 transcription levels were also significantly reduced in the blood of ART-treated AIDS patients irrespective of viral status.
|
28478499 |
2017 |
|
Arteriosclerosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, a specific deletion of DNGR-1 in CD8α<sup>+</sup> DCs significantly increases IL-10 expression, reduces macrophage and T-cell contents within the lesions, and limits the development of atherosclerosis.
|
28607102 |
2017 |
|
Atherosclerosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Furthermore, a specific deletion of DNGR-1 in CD8α<sup>+</sup> DCs significantly increases IL-10 expression, reduces macrophage and T-cell contents within the lesions, and limits the development of atherosclerosis.
|
28607102 |
2017 |
|
Hypercholesterolemia
|
0.010 |
Biomarker
|
disease |
BEFREE |
We show that total absence of DNGR-1 in Apoe (apolipoprotein e)-deficient mice (<i>Apoe</i><sup>-/-</sup>) and bone marrow-restricted deletion of DNGR-1 in Ldlr (low-density lipoprotein receptor)-deficient mice (<i>Ldlr</i><sup>-/-</sup>) significantly reduce inflammatory cell content within arterial plaques and limit atherosclerosis development in a context of moderate hypercholesterolemia.
|
28607102 |
2017 |
|
Immunologic Deficiency Syndromes
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The levels of DNGR-1 and its ligand-bearing cells were altered after human and simian immunodeficiency virus infection.
|
28478499 |
2017 |
|
Mycobacterium Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
These findings demonstrate that CLEC9A is a specialized receptor that modulates the innate immune response when there is a mycobacterial infection.
|
29065139 |
2017 |
|
Pneumonia
|
0.010 |
Biomarker
|
disease |
BEFREE |
In a in vivo mouse model, when the interaction between CLEC9A and H37Ra is interfered with by treatment with CLEC9A-Fc fusion protein, this reduces lung inflammation and cell infiltration.
|
29065139 |
2017 |
|
Tuberculosis
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Our results with CLEC9A-knocked down cells and a CLEC9A-Fc fusion protein as blocking agents show that CLEC9A is involved in the activation of SYK and MAPK signaling in response to heat-killed M. tuberculosis H37Ra treatment, and it then promotes the production of CXCL8 and IL-1β in macrophages.
|
29065139 |
2017 |
|
Virus Diseases
|
0.010 |
AlteredExpression
|
group |
BEFREE |
The levels of DNGR-1 and its ligand-bearing cells were altered after human and simian immunodeficiency virus infection.
|
28478499 |
2017 |
|
hiv-infection/aids
|
0.010 |
Biomarker
|
disease |
BEFREE |
The expression of DNGR-1 that is highly similar to that of humans warranted the usefulness of rhesus macaques in testing human therapeutics and vaccines targeting DNGR-1, especially those for HIV/AIDS.
|
28511091 |
2017 |
|
Vascular inflammations
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
Our results unravel a new role of DNGR-1 in regulating vascular inflammation and atherosclerosis and potentially identify a new target for disease modulation.
|
28607102 |
2017 |
|
Pneumonitis
|
0.010 |
Biomarker
|
disease |
BEFREE |
In a in vivo mouse model, when the interaction between CLEC9A and H37Ra is interfered with by treatment with CLEC9A-Fc fusion protein, this reduces lung inflammation and cell infiltration.
|
29065139 |
2017 |
|
Herpes Simplex Infections
|
0.010 |
Biomarker
|
group |
BEFREE |
DNGR-1 regulated cross-priming in non-infectious settings such as immunization with antigen-bearing dead cells, as well as in highly immunogenic situations such as infection with herpes simplex virus type 1.
|
22505458 |
2012 |