KSR2, kinase suppressor of ras 2, 283455

N. diseases: 27; N. variants: 13
Disease: Obesity ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0028754
Disease: Obesity
Obesity 		0.340 GeneticVariation disease BEFREE We identified 14 coding variants in 13 genes, of which 8 variants were in genes (ZBTB7B, ACHE, RAPGEF3, RAB21, ZFHX3, ENTPD6, ZFR2 and ZNF169) newly implicated in human obesity, 2 variants were in genes (MC4R and KSR2) previously observed to be mutated in extreme obesity and 2 variants were in GIPR. 29273807 2018
CUI: C0028754
Disease: Obesity
Obesity 		0.340 Biomarker disease GENOMICS_ENGLAND We identified 14 coding variants in 13 genes, of which 8 variants were in genes (ZBTB7B, ACHE, RAPGEF3, RAB21, ZFHX3, ENTPD6, ZFR2 and ZNF169) newly implicated in human obesity, 2 variants were in genes (MC4R and KSR2) previously observed to be mutated in extreme obesity and 2 variants were in GIPR. 29273807 2018
CUI: C0028754
Disease: Obesity
Obesity 		0.340 Biomarker disease BEFREE KSR2 disruption in humans and mice causes obesity and insulin resistance. 28180061 2017
CUI: C0028754
Disease: Obesity
Obesity 		0.340 GeneticVariation disease BEFREE Rare KSR2 mutations have been reported to be associated with early onset obesity and insulin resistance. 26507551 2015
CUI: C0028754
Disease: Obesity
Obesity 		0.340 Biomarker disease BEFREE Modulation of KSR2-mediated effects may represent a novel therapeutic strategy for obesity and type 2 diabetes. 24209692 2013