|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Detailed characterization of the novel spontaneously immortalized cell line, VCC1 revealed a characteristic epithelial morphology in vitro and a well-differentiated keratinizing SCC histology in vivo, closely resembling the tumor of origin.
|
31654625 |
2020 |
|
Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
Tumor cell expression of B7-H4 correlates with higher frequencies of tumor-infiltrating APCs and higher CXCL17 expression in human epithelial ovarian cancer.
|
31741762 |
2019 |
|
Neoplasms
|
0.070 |
AlteredExpression
|
group |
BEFREE |
CXCL17 was recently shown to be ectopically expressed in colon cancer tumors.
|
30198422 |
2018 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
CXCL17 also has a role in angiogenesis of importance for tumour development.
|
26889977 |
2016 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
Our data showed that CXCL17-expressing tumor cells increased immature CD11b(+)Gr1(+) myeloid-derived cells at tumor sites in mice and promoted CD31(+) tumor angiogenesis.
|
22952881 |
2012 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
These results strongly suggest that VCC-1 plays an important role in SMMC7721 invasion and tumor growth, and indicate that VCC-1 may serve as a potential biomarker for anti-HCC therapies.
|
19657564 |
2009 |
|
Neoplasms
|
0.070 |
Biomarker
|
group |
BEFREE |
These results strongly suggest that VCC-1 plays a role in angiogenesis and possibly in the development of tumors in some tissue types.
|
16989774 |
2006 |
|
Neoplasm Metastasis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
The oncogenic properties CXCL17 were examined by in vivo spontaneous metastasis mouse model.
|
30755260 |
2019 |
|
Neoplasm Metastasis
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
Our study examined the activity and mechanisms of CXCL17 on growth, autophagy, and metastasis of HCC.
|
30597237 |
2019 |
|
Liver carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
Altogether, these findings suggest that elevated CXCL17 expression in HCC promotes malignant reactions in malignant cells.
|
30597237 |
2019 |
|
Neoplasm Metastasis
|
0.040 |
Biomarker
|
phenotype |
BEFREE |
The present review will focus on the signaling pathways that DMC utilizes to modulate the growth, invasion, and metastasis of cancer cells in an effort to provide enhanced mechanistic insight into DMC's action as it pertains to brain, ovarian, breast, lung, skin, and prostate cancer.
|
30076727 |
2018 |
|
Liver carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
We examined CXCL17 expression in 227 HCC tissue specimens by immunohistochemical staining, and correlated CXCL17 expression patterns with clinicopathological features, prognosis, and immune infiltrate density (CD4 T cells, CD8 T cells, B cells, natural killer cells, neutrophils, macrophages).
|
25303284 |
2014 |
|
Neoplasm Metastasis
|
0.040 |
AlteredExpression
|
phenotype |
BEFREE |
Although CXCL17 expression could not increase the number of CD11b(+)Gr1(+) cells in tumor-burdened SCID mice or promote metastases of low metastatic colon cancer cells, the existence of CXCL17-responding myeloid-derived cells caused a striking enhancement of xenograft tumor formation.
|
22952881 |
2012 |
|
Liver carcinoma
|
0.040 |
AlteredExpression
|
disease |
BEFREE |
In this study, we found that VCC-1 was highly expressed in hepatocellular carcinoma (HCC) tissue.
|
22425983 |
2012 |
|
Liver carcinoma
|
0.040 |
Biomarker
|
disease |
BEFREE |
These results strongly suggest that VCC-1 plays an important role in SMMC7721 invasion and tumor growth, and indicate that VCC-1 may serve as a potential biomarker for anti-HCC therapies.
|
19657564 |
2009 |
|
Carcinogenesis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
In conclusion, VCC1 mirrored several major VLS-VSCC features and provided a robust experimental tool for further elucidation of VLS-related oncogenesis and drug testing.
|
31654625 |
2020 |
|
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
In vitro 3D organotypic assays and in vivo xenografts revealed a prominent role of cancer-associated fibroblasts in VCC1 invasion and tumor formation.
|
31654625 |
2020 |
|
Tumor Cell Invasion
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Our research offers new evidence that chemokine CXCL17 reinforces malignant invasion and suppresses autophagy via the LKB1-AMPK pathway.
|
30597237 |
2019 |
|
Carcinogenesis
|
0.030 |
GeneticVariation
|
phenotype |
BEFREE |
Vascular endothelial growth factor-correlated chemokine 1 (VCC-1), a recently described chemokine, is hypothesized to be associated with carcinogenesis.
|
22425983 |
2012 |
|
Carcinogenesis
|
0.030 |
Biomarker
|
phenotype |
BEFREE |
Vascular endothelial growth factor-correlated chemokine 1 (VCC-1), a novel chemokine, is hypothesized to be associated with carcinogenesis.
|
19657564 |
2009 |
|
Tumor Cell Invasion
|
0.030 |
AlteredExpression
|
phenotype |
BEFREE |
Overexpression of VCC-1 gene in human hepatocellular carcinoma cells promotes cell proliferation and invasion.
|
19657564 |
2009 |
|
Adenocarcinoma of lung (disorder)
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
We found that the expression of CXCL17 was higher in clinical LUAD samples and LUAD cell lines than in lung squamous cell carcinoma (LUSC) samples and cell lines.
|
31832986 |
2020 |
|
Malignant neoplasm of breast
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our study reveals that MDSCs derived by CXCL17 contribute to the establishment of a lung metastatic niche by PDGF-BB secretion and provide a rationale for development of CXCL17 or PDGF-BB antagonists to inhibit or prevent lung metastasis in cases of breast cancer.
|
30755260 |
2019 |
|
Adenocarcinoma of lung (disorder)
|
0.020 |
AlteredExpression
|
disease |
BEFREE |
The comparison between LAC and benign samples revealed significantly different plasma levels for four proteins; CXCL17, CEACAM5, VEGFR2 and ERBB3 (adjusted p-value < 0.05).
|
31357969 |
2019 |
|
Breast Carcinoma
|
0.020 |
Biomarker
|
disease |
BEFREE |
Our study reveals that MDSCs derived by CXCL17 contribute to the establishment of a lung metastatic niche by PDGF-BB secretion and provide a rationale for development of CXCL17 or PDGF-BB antagonists to inhibit or prevent lung metastasis in cases of breast cancer.
|
30755260 |
2019 |