|
Male infertility
|
0.010 |
Biomarker
|
phenotype |
BEFREE |
These data demonstrate that EMC10 is indispensable to male fertility via maintaining sperm ion balance of Na+ and HCO3-, and also suggest that EMC10 is a promising biomarker for male fertility and a potential pharmaceutical target to treat male infertility.
|
29659949 |
2018 |
|
Asthenozoospermia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Mechanistically, EMC10 deficiency leads to inactivation of Na/K-ATPase, in turn giving rise to an increased level of intracellular Na+ in spermatozoa, which contributes to decreased sperm motility and abnormal morphology.
|
29659949 |
2018 |
|
Heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, we explored the therapeutic potential of recombinant Emc10 delivered by osmotic minipumps after MI in heart failure-prone FVB/N mice.
|
28931551 |
2017 |
|
Congestive heart failure
|
0.010 |
Biomarker
|
disease |
BEFREE |
Furthermore, we explored the therapeutic potential of recombinant Emc10 delivered by osmotic minipumps after MI in heart failure-prone FVB/N mice.
|
28931551 |
2017 |
|
Myocardial Infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
EMC10 (Endoplasmic Reticulum Membrane Protein Complex Subunit 10) Is a Bone Marrow-Derived Angiogenic Growth Factor Promoting Tissue Repair After Myocardial Infarction.
|
28931551 |
2017 |
|
Acute myocardial infarction
|
0.010 |
Biomarker
|
disease |
BEFREE |
Emc10 protein abundance was increased in the infarcted region of the left ventricle and in the circulation of wild-type mice after MI.
|
28931551 |
2017 |
|
Astrocytoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Further, preliminary immunohistochemical analysis revealed an increase in hHSS1/HSM1 immunoreactivity in two out of four high-grade astrocytomas (glioblastoma multiforme, WHO IV) as compared to low expression in all four low-grade diffuse astrocytomas (WHO grade II).
|
20680400 |
2011 |
|
Malignant Neoplasms
|
0.010 |
Biomarker
|
group |
BEFREE |
Our data reveal that HSS1 is a truly novel protein defining a new class of secreted factors, and that it may have an important role in cancer, particularly glioma.
|
20680400 |
2011 |
|
Glioblastoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Further, preliminary immunohistochemical analysis revealed an increase in hHSS1/HSM1 immunoreactivity in two out of four high-grade astrocytomas (glioblastoma multiforme, WHO IV) as compared to low expression in all four low-grade diffuse astrocytomas (WHO grade II).
|
20680400 |
2011 |
|
Glioma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Our data reveal that HSS1 is a truly novel protein defining a new class of secreted factors, and that it may have an important role in cancer, particularly glioma.
|
20680400 |
2011 |
|
Malignant Glioma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Interestingly, the human HSS1 (hHSS1) gene is located at chromosome 19q13.33, a genomic region implicated in various cancers, including malignant glioma.
|
20680400 |
2011 |
|
Primary malignant neoplasm
|
0.010 |
Biomarker
|
group |
BEFREE |
Our data reveal that HSS1 is a truly novel protein defining a new class of secreted factors, and that it may have an important role in cancer, particularly glioma.
|
20680400 |
2011 |
|
Glioblastoma Multiforme
|
0.010 |
Biomarker
|
disease |
BEFREE |
Further, preliminary immunohistochemical analysis revealed an increase in hHSS1/HSM1 immunoreactivity in two out of four high-grade astrocytomas (glioblastoma multiforme, WHO IV) as compared to low expression in all four low-grade diffuse astrocytomas (WHO grade II).
|
20680400 |
2011 |
|
Hereditary spherocytosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The most significant quantitative trait locus, Hsm1 (hereditary spherocytosis modifier 1), localizes to mouse Chromosome 12 and is dominant.
|
15070709 |
2004 |