|
Chronic Lymphocytic Leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Mutated IGHV was detected in 71·2% of Taiwanese CLL and IGHV3-23 was the most frequently used gene.
|
31230372 |
2019 |
|
Chronic Lymphocytic Leukemia
|
0.020 |
Biomarker
|
disease |
BEFREE |
Compared with M non-IGHV3-23 CLL, the gene expression profile of M IGHV3-23 CLL was deprived in genes, including the growth/tumor suppressor genes PDCD4, TIA1, and RASSF5, whose downregulation is under control of miR-15a and miR-16-1.
|
20068100 |
2010 |
|
Multiple Sclerosis
|
0.010 |
Biomarker
|
disease |
BEFREE |
Compared to patients with Intracranial hypertension, the following CSF proteins: Extracellular Superoxide dismutase (ECSOD) at Cys195, α1-antitrypsin (A1AT) at Cys232, Phospholipid transfer protein (PLTP) at Cys318, Alpha-2-HS-glycoprotein at Cys340, Ectonucleotide pyrophosphate (ENPP-2) at Cys773, Gelsolin at Cys304, Interleukin-18 (IL-18) at Cys38 and Ig heavy chain V III region POM at Cys22 were found to be glutathionylated in patients with multiple sclerosis during a relapse.
|
30367882 |
2019 |
|
Lymphocytosis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Among WM and IgM-MGUS, MYD88 L265P mutation was associated with some differences in clinical and biological characteristics, although usually minor; wild-type MYD88 cases had smaller M-component (1.77 vs 2.72 g/dl, P=0.022), more lymphocytosis (24 vs 5%, P=0.006), higher lactate dehydrogenase level (371 vs 265 UI/L, P=0.002), atypical immunophenotype (CD23-CD27+ +FMC7+ +), less Immunoglobulin Heavy Chain Variable gene (IGHV) somatic hypermutation (57 vs 97%, P=0.012) and less IGHV3-23 gene selection (9 vs 27%, P=0.014).
|
23446312 |
2013 |
|
Waldenstrom Macroglobulinemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Among WM and IgM-MGUS, MYD88 L265P mutation was associated with some differences in clinical and biological characteristics, although usually minor; wild-type MYD88 cases had smaller M-component (1.77 vs 2.72 g/dl, P=0.022), more lymphocytosis (24 vs 5%, P=0.006), higher lactate dehydrogenase level (371 vs 265 UI/L, P=0.002), atypical immunophenotype (CD23-CD27+ +FMC7+ +), less Immunoglobulin Heavy Chain Variable gene (IGHV) somatic hypermutation (57 vs 97%, P=0.012) and less IGHV3-23 gene selection (9 vs 27%, P=0.014).
|
23446312 |
2013 |
|
Diffuse Large B-Cell Lymphoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
Systemic HIV-diffuse large B-cell lymphomas displayed underrepresentation of the IGHV3 family (11/38, 28.9%; p=0.0047) and, in particular, of the IGHV3-23 gene (0/38; p<0.001).
|
18556404 |
2008 |
|
Leukemia, Prolymphocytic, B-Cell
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
All B-PLL utilized members of VH3 (11/17) and VH4 (6/17) families, with V3-23, V4-59 and V4-34 gene accounting for more than half of them, regardless of mutational status.
|
16642047 |
2006 |
|
Mucosa-Associated Lymphoid Tissue Lymphoma
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Sequencing of VH genes revealed that the VH3 family was the most commonly expressed germline VH family (70%) and that DP-63, DP-54 and DP-47 genes were frequently found in the MALT lymphomas examined.
|
11454995 |
2001 |
|
Hashimoto Disease
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
A biased usage of V(H) 3 and V(H) 4 genes with the homologous germline gene of VH26 in V(H) 3 gene was reported previously in cases with CLTH.
|
11676854 |
2001 |
|
Hyper-IgM Immunodeficiency Syndrome, Type 1
|
0.010 |
Biomarker
|
disease |
BEFREE |
Unique among the V(H)3 genes, V(H)3-23/DP-47 was positively selected in both normals and the X-HIgM patient.
|
10837404 |
2000 |
|
Prolymphocytic Leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
To better characterize the nature of the cellular origin in this disease, we analyzed lg heavy chain variable region (VH) genes in eleven cases of de novo PLL Leukemic cells expressed a skewed repertoire characterized by predominant use of the V3 family members (73%), with preferential use of the V3-23 gene (50% of the VH3 genes).
|
8916962 |
1996 |