|
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Sepsis is a pathological host response to infection leading to vascular barrier breakdown due to elevated levels of angiopoietin-2 (Angpt-2) and vascular endothelial growth factor-A (VEGF-A).
|
31726451 |
2020 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Angpt-2 was significantly higher in this cohort with severe sepsis/septic shock compared with children without SIRS and SIRS/sepsis (all P < 0.003).
|
30286031 |
2019 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Four latent factors (Factor 1-4) were identified, each potentially representing distinct biological processes for the endothelial response to sepsis: Factor 1 (CHI3L1, sTREM1, sFLT1); Factor 2 (ANGPT1, PF4, VEGF); Factor 3 (CXCL10, VWF, sICAM1); and Factor 4 (ANGPT2, sTEK).
|
31013257 |
2019 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
We determined whether concentrations of soluble tumor necrosis factor receptor-1 (sTNFR1), interleukin-8 (IL8), and angiopoietin-2 (Ang2) could identify sepsis patients at higher mortality risk and serve as prognostic enrichment factors.
|
31818332 |
2019 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Association of Ang-2, vWF, and EVLWI with risk of mortality in sepsis patients with concomitant ARDS: A retrospective study.
|
31822372 |
2019 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
The findings suggest that PTX3, MCP1 and Ang2 maybe early predictors to evaluate the severity of sepsis and septic shock with the latest Sepsis 3.0 definitions.
|
31489646 |
2019 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Ang-1, Ang-2, and suPAR provide beneficial prognostic information about mortality in adult patients with sepsis.
|
31705327 |
2019 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Tie2 activation by angiopoietin-1 reduces, whereas Tie2 blockade by angiopoietin-2 increases, inflammation and permeability during sepsis.
|
29447449 |
2018 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Ang-2 concentrations at presentation were higher among infants who subsequently died of sepsis compared to survivors (aOR 2.50, p = 0.024).
|
29571293 |
2018 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
This study demonstrates that Ang-2 levels are significantly upregulated in SAC, and this biomarker can be used to risk stratify patients with sepsis into non-overt DIC and overt DIC.
|
29996658 |
2018 |
|
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
ANG2 was the only gene whose expression was significantly increased in patients developing severe sepsis than in those with uncomplicated sepsis.
|
29413717 |
2018 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Flunarizine suppresses endothelial Angiopoietin-2 in a calcium - dependent fashion in sepsis.
|
28276491 |
2017 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Not surprisingly, increased levels of key angiogenic proteins such as VEGF-A and Angiopoietin-2 have been described in sepsis.
|
28746898 |
2017 |
|
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Serum levels of VEGF, SDF-1, and Angiopoietin-2 were also higher in preterm infants with sepsis than in control non-sepsis.
|
28294401 |
2017 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Vascular inflammation and leakage in sepsis is mediated by Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) and their phosphorylation of the endothelial Tie-2 receptor.
|
28538018 |
2017 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Angiopoietin-1 (Ang-1)-mediated Tie2 activation reduces, and the Ang-1 antagonist Ang-2 increases, inflammation and endothelial permeability in sepsis.
|
29132435 |
2017 |
|
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
Levels of cAng-2 were higher under severe sepsis and septic shock, as compared to uncomplicated sepsis; PBMC Ang-2 copies were higher in severe sepsis.
|
25748839 |
2015 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
These results put in evidence a striking protective role of Ang-2 in experimental sepsis evoked by a multidrug-resistant isolate of P. aeruginosa attributed to modulation of TNF-α production and changes in neutrophil migration.
|
22859861 |
2012 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
Angiopoietin-2 is largely a competitive partial antagonist that is markedly elevated in humans and animal models of sepsis and other inflammatory states, directly disrupts the endothelial barrier, and has been correlated with end-organ dysfunction and death in sepsis.
|
23171759 |
2012 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
: We conclude that angiopoietin-2 induction precedes and contributes to the adverse outcomes in sepsis, opening a new avenue for therapeutic investigation.
|
22890252 |
2012 |
|
Septicemia
|
0.100 |
Biomarker
|
disease |
BEFREE |
In order to reverse the effects of the sepsis-induced suppression of Ang-1 and elevation of Ang-2 we aimed to investigate whether an intravenous injection of recombinant human (rh) Ang-1 protects against MODS in murine sepsis.
|
21531574 |
2011 |
|
Septicemia
|
0.100 |
AlteredExpression
|
disease |
BEFREE |
We conclude that in vivo endotoxemia triggers functional inhibition of the Ang-1/Tie-2 receptor pathway by reducing Ang-1 and Tie-2 expression and inducing Ang-2 levels and that this response may contribute to enhanced vascular leakage in sepsis.
|
18310225 |
2008 |