CCDC66, coiled-coil domain containing 66, 285331

N. diseases: 17; N. variants: 3
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0035334
Disease: Retinitis Pigmentosa
Retinitis Pigmentosa 		0.210 GeneticVariation disease BEFREE In Schapendoes dogs, for example, a mutation in the CCDC66 gene has been shown to cause autosomal recessively inherited, generalized progressive retinal atrophy (gPRA), the canine counterpart to RP. 21680557 2011
CUI: C0035334
Disease: Retinitis Pigmentosa
Retinitis Pigmentosa 		0.210 Biomarker disease MGD
CUI: C0220701
Disease: RETINITIS PIGMENTOSA 1
RETINITIS PIGMENTOSA 1 		0.200 Biomarker disease MGD
CUI: C0023467
Disease: Leukemia, Myelocytic, Acute
Leukemia, Myelocytic, Acute 		0.100 GeneticVariation disease GWASCAT Genome-wide haplotype association study identify the FGFR2 gene as a risk gene for acute myeloid leukemia. 27903959 2017
CUI: C0009402
Disease: Colorectal Carcinoma
Colorectal Carcinoma 		0.010 AlteredExpression disease BEFREE In addition, the plasma circ-ABCC1 level was related to tumor growth and progression, and the plasma circ-CCDC66 and circ-ABCC1 levels were decreased in precursor lesions of CRC, including colon adenomas and adenomatous polyps. 31669510 2019
CUI: C0019569
Disease: Hirschsprung Disease
Hirschsprung Disease 		0.010 AlteredExpression disease BEFREE In conclusion, this is the first report revealing that cir-CCDC66 modulates DCX expression through sponging miR-488-3p and thus participates in the onset of HSCR. 30443988 2019
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.010 Biomarker disease BEFREE The potential influences of circ-CCDC66 on proliferative and invasive abilities of GC cells were evaluated through 5-Ethynyl-2'-deoxyuridine (EdU), colony formation and transwell assay, respectively. 31173287 2019
CUI: C0206677
Disease: Adenomatous Polyps
Adenomatous Polyps 		0.010 AlteredExpression disease BEFREE In addition, the plasma circ-ABCC1 level was related to tumor growth and progression, and the plasma circ-CCDC66 and circ-ABCC1 levels were decreased in precursor lesions of CRC, including colon adenomas and adenomatous polyps. 31669510 2019
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.010 Biomarker disease BEFREE The potential influences of circ-CCDC66 on proliferative and invasive abilities of GC cells were evaluated through 5-Ethynyl-2'-deoxyuridine (EdU), colony formation and transwell assay, respectively. 31173287 2019
CUI: C1269955
Disease: Tumor Cell Invasion
Tumor Cell Invasion 		0.010 Biomarker phenotype BEFREE Circ-CCDC66 accelerates proliferation and invasion of gastric cancer via binding to miRNA-1238-3p. 31173287 2019
CUI: C0035309
Disease: Retinal Diseases
Retinal Diseases 		0.010 Biomarker group BEFREE Although Ccdc66 mutations have been proposed to cause retinal disease in dogs, our results and public databases challenge CCDC66 as a candidate gene for human retinal dystrophy. 28369829 2018
CUI: C0152013
Disease: Adenocarcinoma of lung (disorder)
Adenocarcinoma of lung (disorder) 		0.010 AlteredExpression disease BEFREE SAE2 and cirRNA CCDC66 were highly expressed in LADC. 29855336 2018
CUI: C0854723
Disease: Retinal Dystrophies
Retinal Dystrophies 		0.010 Biomarker group BEFREE Although Ccdc66 mutations have been proposed to cause retinal disease in dogs, our results and public databases challenge CCDC66 as a candidate gene for human retinal dystrophy. 28369829 2018
CUI: C0007102
Disease: Malignant tumor of colon
Malignant tumor of colon 		0.010 Biomarker disease BEFREE Noncoding Effects of Circular RNA CCDC66 Promote Colon Cancer Growth and Metastasis. 28249903 2017
CUI: C0027627
Disease: Neoplasm Metastasis
Neoplasm Metastasis 		0.010 Biomarker phenotype BEFREE Noncoding Effects of Circular RNA CCDC66 Promote Colon Cancer Growth and Metastasis. 28249903 2017
CUI: C0699790
Disease: Colon Carcinoma
Colon Carcinoma 		0.010 Biomarker disease BEFREE Noncoding Effects of Circular RNA CCDC66 Promote Colon Cancer Growth and Metastasis. 28249903 2017
CUI: C0521691
Disease: Generalized progressive retinal atrophy
Generalized progressive retinal atrophy 		0.010 Biomarker disease BEFREE Here, a novel mouse model with a disrupted Ccdc66 gene was investigated to reveal the function of protein CCDC66 and the pathogenesis of this form of gPRA. 21680557 2011
CUI: C3669212
Disease: Progressive retinal atrophy
Progressive retinal atrophy 		0.010 GeneticVariation disease BEFREE Progressive retinal atrophy in Schapendoes dogs: mutation of the newly identified CCDC66 gene. 19777273 2010