TRAV4, T cell receptor alpha variable 4, 28689

N. diseases: 3; N. variants: 0
Disease: Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0027651
Disease: Neoplasms
Neoplasms 		0.010 Biomarker group BEFREE Here we show that the structures of two distinct TCRs (TRAV4<sup>+</sup>TRAJ21<sup>+</sup>-TRBV28<sup>+</sup>TRBJ2-3<sup>+</sup> and TRAV4 <sup>+</sup> TRAJ8<sup>+</sup>-TRBV9<sup>+</sup>TRBJ2-1<sup>+</sup>), originating from a polyclonal T-cell repertoire, bind to HLA-B*07:02, presenting a 13-amino-acid-long tumour-associated peptide, NY-ESO-1<sub>60-72</sub>. 29531227 2018