TRAC, T cell receptor alpha constant, 28755

N. diseases: 28; N. variants: 1
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C3809332
Disease: T-CELL RECEPTOR-ALPHA/BETA DEFICIENCY
T-CELL RECEPTOR-ALPHA/BETA DEFICIENCY 		0.700 Biomarker disease GENOMICS_ENGLAND Inherited polymorphism of the human T-cell antigen receptor detected by a monoclonal antibody. 3464003 1986
CUI: C3809332
Disease: T-CELL RECEPTOR-ALPHA/BETA DEFICIENCY
T-CELL RECEPTOR-ALPHA/BETA DEFICIENCY 		0.700 Biomarker disease CTD_human
CUI: C3809332
Disease: T-CELL RECEPTOR-ALPHA/BETA DEFICIENCY
T-CELL RECEPTOR-ALPHA/BETA DEFICIENCY 		0.700 GermlineCausalMutation disease ORPHANET Mutation in the TCRα subunit constant gene (TRAC) leads to a human immunodeficiency disorder characterized by a lack of TCRαβ+ T cells. 21206088 2011
CUI: C3809332
Disease: T-CELL RECEPTOR-ALPHA/BETA DEFICIENCY
T-CELL RECEPTOR-ALPHA/BETA DEFICIENCY 		0.700 CausalMutation disease CLINVAR
CUI: C0494261
Disease: Combined immunodeficiency
Combined immunodeficiency 		0.300 Biomarker disease GENOMICS_ENGLAND Inherited polymorphism of the human T-cell antigen receptor detected by a monoclonal antibody. 3464003 1986
CUI: C0015544
Disease: Failure to Thrive
Failure to Thrive 		0.100 Biomarker disease HPO
CUI: C0745091
Disease: Hypereosinophilia
Hypereosinophilia 		0.100 Biomarker disease HPO
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.020 Biomarker disease BEFREE These linkage studies provide no significant evidence of a major germline-encoded TCRA or TCRB component of susceptibility to RA. 9336413 1997
CUI: C0003873
Disease: Rheumatoid Arthritis
Rheumatoid Arthritis 		0.020 Biomarker disease BEFREE These findings show evidence that TCRA is an RA susceptibility locus. 9259417 1997
CUI: C0004096
Disease: Asthma
Asthma 		0.010 Biomarker disease BEFREE Taken together, naive T cells in asthma have a peculiar function to produce TRAC and MDC, which contribute to local migration of Th2 cells into lung and lymphoid tissues, along with a function as precursor for memory/effector T cell. 12645858 2003
CUI: C0011854
Disease: Diabetes Mellitus, Insulin-Dependent
Diabetes Mellitus, Insulin-Dependent 		0.010 Biomarker disease BEFREE Non-HLA genetic factors and insulin dependent diabetes mellitus in the Japanese: TCRA, TCRB and TCRG, INS, THY1, CD3D and ETS1. 1982251 1991
CUI: C0017661
Disease: IGA Glomerulonephritis
IGA Glomerulonephritis 		0.010 GeneticVariation disease BEFREE The T cell receptor alpha constant gene (TRAC) encodes the constant region of the alpha chain for the T cell receptor, and the association of its gene variants with IgA nephropathy remains controversial. 19470682 2009
CUI: C0019829
Disease: Hodgkin Disease
Hodgkin Disease 		0.010 Biomarker disease BEFREE Chromosomal in situ hybridization of a Hodgkin's disease-derived cell line (L540) using DNA probes for TCRA, TCRB, MET, and rRNA. 2323775 1990
CUI: C0023449
Disease: Acute lymphocytic leukemia
Acute lymphocytic leukemia 		0.010 AlteredExpression disease BEFREE Here we show that directing a CD19-specific CAR to the T-cell receptor α constant (TRAC) locus not only results in uniform CAR expression in human peripheral blood T cells, but also enhances T-cell potency, with edited cells vastly outperforming conventionally generated CAR T cells in a mouse model of acute lymphoblastic leukaemia. 28225754 2017
CUI: C0023492
Disease: Leukemia, T-Cell
Leukemia, T-Cell 		0.010 GeneticVariation disease BEFREE The 14q32.13 breakpoints were mapped by fluorescence in situ hybridization (FISH) in the region harboring the TCL1A/TCL1B/TCL6 genes, known to be affected by TCRA/D-mediated t(14;14)(q11;q32)/inv(14)(q11q32) occurring in T-cell leukemia/lymphoma. 22553924 2012
CUI: C0024623
Disease: Malignant neoplasm of stomach
Malignant neoplasm of stomach 		0.010 Biomarker disease BEFREE TRAC and qRT-PCR analyses validated the microarray results and therefore the role of these genes as potential biomarkers for gastric cancer. 20187983 2010
CUI: C0027404
Disease: Narcolepsy
Narcolepsy 		0.010 GeneticVariation disease BEFREE Chinese narcolepsy was strongly and dose dependently associated with TCRA (rs1154155C) and P2RY11 (rs2305795A) but not CPT1B/CHKB (rs5770917C) polymorphisms. 22177342 2012
CUI: C0035412
Disease: Rhabdomyosarcoma
Rhabdomyosarcoma 		0.010 AlteredExpression disease BEFREE TCRA ectopic transcripts/proteins negatively regulate rhabdomyosarcoma cell growth as suggested by TCRA gene expression downmodulation effects using a specific duplex small interfering RNA. 15935573 2005
CUI: C0036920
Disease: Sezary Syndrome
Sezary Syndrome 		0.010 Biomarker disease BEFREE The lack of clear stereotypic TCRA and TCRB CDR3 amino acid motifs would argue against involvement of a single common antigen in the pathogenesis of SS. 21410672 2011
CUI: C0038013
Disease: Ankylosing spondylitis
Ankylosing spondylitis 		0.010 GeneticVariation disease BEFREE It is unlikely that either the TCRA/D or TCRB loci contain genes responsible for more than a moderate proportion of the non-MHC genetic susceptibility to ankylosing spondylitis. 9619899 1998
CUI: C0220611
Disease: Childhood Rhabdomyosarcoma
Childhood Rhabdomyosarcoma 		0.010 AlteredExpression disease BEFREE TCRA ectopic transcripts/proteins negatively regulate rhabdomyosarcoma cell growth as suggested by TCRA gene expression downmodulation effects using a specific duplex small interfering RNA. 15935573 2005
CUI: C0279550
Disease: Adult Rhabdomyosarcoma
Adult Rhabdomyosarcoma 		0.010 AlteredExpression disease BEFREE TCRA ectopic transcripts/proteins negatively regulate rhabdomyosarcoma cell growth as suggested by TCRA gene expression downmodulation effects using a specific duplex small interfering RNA. 15935573 2005
CUI: C0406810
Disease: Carney Complex
Carney Complex 		0.010 GeneticVariation disease BEFREE We further demonstrate that targeting the CAR to the TRAC locus averts tonic CAR signalling and establishes effective internalization and re-expression of the CAR following single or repeated exposure to antigen, delaying effector T-cell differentiation and exhaustion. 28225754 2017
CUI: C0699791
Disease: Stomach Carcinoma
Stomach Carcinoma 		0.010 Biomarker disease BEFREE TRAC and qRT-PCR analyses validated the microarray results and therefore the role of these genes as potential biomarkers for gastric cancer. 20187983 2010
CUI: C1961099
Disease: Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma 		0.010 GeneticVariation disease BEFREE The combined results indicate that IGH gene rearrangements in T-ALL are postoncogenic processes, which are absent in T-ALL with deleted TCRD genes and completed TCR alpha (TCRA) gene rearrangements. 10361104 1999