|
T-CELL RECEPTOR-ALPHA/BETA DEFICIENCY
|
0.700 |
GermlineCausalMutation
|
disease |
ORPHANET |
Mutation in the TCRα subunit constant gene (TRAC) leads to a human immunodeficiency disorder characterized by a lack of TCRαβ+ T cells.
|
21206088 |
2011 |
|
T-CELL RECEPTOR-ALPHA/BETA DEFICIENCY
|
0.700 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Inherited polymorphism of the human T-cell antigen receptor detected by a monoclonal antibody.
|
3464003 |
1986 |
|
T-CELL RECEPTOR-ALPHA/BETA DEFICIENCY
|
0.700 |
Biomarker
|
disease |
CTD_human |
|
|
|
|
T-CELL RECEPTOR-ALPHA/BETA DEFICIENCY
|
0.700 |
CausalMutation
|
disease |
CLINVAR |
|
|
|
|
Combined immunodeficiency
|
0.300 |
Biomarker
|
disease |
GENOMICS_ENGLAND |
Inherited polymorphism of the human T-cell antigen receptor detected by a monoclonal antibody.
|
3464003 |
1986 |
|
Autoimmune state
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Failure to Thrive
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Recurrent infections
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Lymphadenopathy
|
0.100 |
Biomarker
|
phenotype |
HPO |
|
|
|
|
Hypereosinophilia
|
0.100 |
Biomarker
|
disease |
HPO |
|
|
|
|
Neoplasms
|
0.030 |
GeneticVariation
|
group |
BEFREE |
Targeting a CAR to the TRAC locus with CRISPR/Cas9 enhances tumour rejection.
|
28225754 |
2017 |
|
Neoplasms
|
0.030 |
Biomarker
|
group |
BEFREE |
Simultaneous detection of TCRA/D or TCRB breaks was achieved in a multicolor approach, which was further combined with detection of the T-cell-specific CD3 antigen in a multicolor FICTION (Fluorescence Immunophenotyping and Interphase Cytogenetics as a Tool for the Investigation of Neoplasm) assay.
|
12682631 |
2003 |
|
Neoplasms
|
0.030 |
GeneticVariation
|
group |
BEFREE |
This translocation had rearranged the TCRA/D locus on chromosome band 14q11 and the locus encoding the tumor suppressor gene P16INK4/MTS1 (P16) on band 9p21 (D. Duro et al., Oncogene, 11: 21-29, 1995).
|
8631023 |
1996 |
|
Rheumatoid Arthritis
|
0.020 |
Biomarker
|
disease |
BEFREE |
These linkage studies provide no significant evidence of a major germline-encoded TCRA or TCRB component of susceptibility to RA.
|
9336413 |
1997 |
|
Rheumatoid Arthritis
|
0.020 |
Biomarker
|
disease |
BEFREE |
These findings show evidence that TCRA is an RA susceptibility locus.
|
9259417 |
1997 |
|
Acute lymphocytic leukemia
|
0.010 |
AlteredExpression
|
disease |
BEFREE |
Here we show that directing a CD19-specific CAR to the T-cell receptor α constant (TRAC) locus not only results in uniform CAR expression in human peripheral blood T cells, but also enhances T-cell potency, with edited cells vastly outperforming conventionally generated CAR T cells in a mouse model of acute lymphoblastic leukaemia.
|
28225754 |
2017 |
|
Carney Complex
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
We further demonstrate that targeting the CAR to the TRAC locus averts tonic CAR signalling and establishes effective internalization and re-expression of the CAR following single or repeated exposure to antigen, delaying effector T-cell differentiation and exhaustion.
|
28225754 |
2017 |
|
T-Cell Prolymphocytic Leukemia
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Two distinct genetic subgroups of T-PLL were identified: A large subset (86% of patients) showed abnormalities involving the TCRA/D locus activating the proto-oncogenes TCL1 or MTCP1, while the second group was characterized by a high frequency of TP53 mutations (4/7 cases).
|
26493028 |
2016 |
|
Leukemia, T-Cell
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The 14q32.13 breakpoints were mapped by fluorescence in situ hybridization (FISH) in the region harboring the TCL1A/TCL1B/TCL6 genes, known to be affected by TCRA/D-mediated t(14;14)(q11;q32)/inv(14)(q11q32) occurring in T-cell leukemia/lymphoma.
|
22553924 |
2012 |
|
Narcolepsy
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
Chinese narcolepsy was strongly and dose dependently associated with TCRA (rs1154155C) and P2RY11 (rs2305795A) but not CPT1B/CHKB (rs5770917C) polymorphisms.
|
22177342 |
2012 |
|
Sezary Syndrome
|
0.010 |
Biomarker
|
disease |
BEFREE |
The lack of clear stereotypic TCRA and TCRB CDR3 amino acid motifs would argue against involvement of a single common antigen in the pathogenesis of SS.
|
21410672 |
2011 |
|
Malignant neoplasm of stomach
|
0.010 |
Biomarker
|
disease |
BEFREE |
TRAC and qRT-PCR analyses validated the microarray results and therefore the role of these genes as potential biomarkers for gastric cancer.
|
20187983 |
2010 |
|
Stomach Neoplasms
|
0.010 |
AlteredExpression
|
group |
BEFREE |
To highlight genes of potential biological and clinical relevance in gastric cancer, we carried out a systematic array-based survey of gene expression and copy number levels in primary gastric tumors and gastric cancer cell lines and validated the results using an affinity capture based transcript analysis (TRAC assay) and real-time qRT-PCR.
|
20187983 |
2010 |
|
Stomach Carcinoma
|
0.010 |
Biomarker
|
disease |
BEFREE |
TRAC and qRT-PCR analyses validated the microarray results and therefore the role of these genes as potential biomarkers for gastric cancer.
|
20187983 |
2010 |
|
IGA Glomerulonephritis
|
0.010 |
GeneticVariation
|
disease |
BEFREE |
The T cell receptor alpha constant gene (TRAC) encodes the constant region of the alpha chain for the T cell receptor, and the association of its gene variants with IgA nephropathy remains controversial.
|
19470682 |
2009 |