GPX1, glutathione peroxidase 1, 2876

N. diseases: 290; N. variants: 12
Disease: Lung Neoplasms ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.350 Biomarker group LHGDN Do genetic factors protect for early onset lung cancer? A case control study before the age of 50 years. 18298806 2008
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.350 Biomarker group LHGDN GPX1 Pro198Leu polymorphism, interactions with smoking and alcohol consumption, and risk for lung cancer. 16797832 2007
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.350 Biomarker group LHGDN Effects of selenium supplementation on expression of glutathione peroxidase isoforms in cultured human lung adenocarcinoma cell lines. 17052796 2007
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.350 AlteredExpression group BEFREE Lung tumours exhibiting 3p LOH (40%) contained higher levels of 8-OHdG adducts (10.9 +/- 2.6 8-OHdG/10(6) dG) (P = 0.05) and lower GPX1 enzyme activity [45.5 nmol glutathione (GSH)/min/mg] (P = 0.09) when compared with tumours without LOH at these sites (5.55 +/- 0.87 8-OHdG/10(6) dG and 63.6 nmol GSH/min/mg, respectively). 10657953 2000
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.350 Biomarker group CTD_human Glutathione peroxidase codon 198 polymorphism variant increases lung cancer risk. 11103801 2000
CUI: C0024121
Disease: Lung Neoplasms
Lung Neoplasms 		0.350 GeneticVariation group BEFREE Nucleotide sequence analysis of GPX1 alleles did not reveal any mutations of this gene in lung tumors. 8001233 1994