GPX1, glutathione peroxidase 1, 2876

N. diseases: 290; N. variants: 12
Disease: Forgetful ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0542476
Disease: Forgetful
Forgetful 		0.030 Biomarker phenotype BEFREE We demonstrated that activation of protein kinase Cδ (PKCδ) and inactivation of the glutathione peroxidase-1 (GPx-1)-dependent systems are critical for methamphetamine (MA)-induced recognition memory impairment. 29572053 2018
CUI: C0542476
Disease: Forgetful
Forgetful 		0.030 Biomarker phenotype BEFREE GPx-1 overexpressing transgenic mice (GPx-1 Tg) were significantly protected from MCLR-induced memory impairment and oxidative stress. 29908255 2018
CUI: C0542476
Disease: Forgetful
Forgetful 		0.030 AlteredExpression phenotype BEFREE We have previously demonstrated that repeated treatment with methamphetamine (MA) results in a recognition memory impairment via upregulation of protein kinase C (PKC) δ and downregulation of the glutathione peroxidase-1 (GPx-1)-dependent antioxidant system. 29476655 2018