|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
High GPx3 expression was associated with poorer overall patient survival and increased tumor stage.
|
30509602 |
2019 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
In summary, our study indicates that GPX3 methylation is associated with cancer and has the potential to become a broad-spectrum tumor screening marker and has a value in predicting tumor lymph node metastasis.
|
31085009 |
2019 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
GPX3 suppresses tumor migration and invasion via the FAK/AKT pathway in esophageal squamous cell carcinoma.
|
30018730 |
2018 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
To further elucidate the mechanism(s) underlying GPx3-medited suppression of tumor proliferation, we next examined the effect of GPx3-mediated redox signaling on the ROS-MKP3-extracellular signal-regulated kinase (Erk)-NF-κB-cyclin B1 pathway and found that GPx3 strongly suppressed activation of the Erk-NF-κB-cyclin B1 signaling cascade by protecting MKP3 (an Erk-specific phosphatase) from the effects of ROS.
|
30260967 |
2018 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
In vivo, GPX3 methylation predicts tumor xenograft sensitivity to platinum with regression of GPX3 knockdown xenografts with platinum treatment but continued growth of GPX3 wild type xenografts in the presence of platinum.
|
27918237 |
2017 |
|
Neoplasms
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
As a crucial antioxidant enzyme, glutathione peroxidase 3 (GPX3) has been found to be frequently repressed in many cancers due to promoter hypermethylation and is known as a possible tumor suppressor gene.
|
27600457 |
2016 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
This result prompted us to investigate whether GPx3 expression is regulated by the glucocorticoid receptor (GR), which is implicated in tumor response to chemotherapy.
|
27484907 |
2016 |
|
Neoplasms
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
GPX3 promoter methylation was detected in 46 of 60 (76.7%) tumors, while no GPX3 gene promoter methylation was observed in the matched non-cancerous specimens.
|
25445749 |
2015 |
|
Neoplasms
|
0.400 |
PosttranslationalModification
|
group |
BEFREE |
GPX3 was methylated in 46.8% (44 of 94) of PTC and methylation of GPX3 was associated with tumor size (P<0.05) and regional lymph node metastasis (P<0.01) significantly.
|
25929866 |
2015 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
In our study, GPX3 methylation and down-regulation were detected in 5 out of 6 ccRCC cell lines and the GPX3 mRNA and protein expression level in ccRCC tumors was significantly lower than in adjacent non-malignant renal tissues (p<0.0001).
|
25970749 |
2015 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
The methylation of THBS1 and GPX3 was not significantly different between the types of tumors, normal sample, the presence of H. pylori, or clinicopathological variables studied (P > 0.05).
|
24014049 |
2014 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
GPx3 could be delivered by hiPSC-MSCs into the tumor and exhibited tumor suppressive activity in vivo.
|
25333265 |
2014 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
A strong correlation between the down-regulation of GPx3 expression and progression of prostate cancer and the suppression of prostate cancer xenografts in SCID mice by forced expression of GPx3 suggests a tumor suppression role of GPx3 in prostate cancer.
|
22461624 |
2012 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
CTD_human |
GPx3 promoter hypermethylation is a frequent event in human cancer and is associated with tumorigenesis and chemotherapy response.
|
21684681 |
2011 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
Overexpression of GPx3 inhibits tumor growth and metastasis.GPx4 is decreased in cancer tissues.
|
19289149 |
2009 |
|
Neoplasms
|
0.400 |
AlteredExpression
|
group |
BEFREE |
The tumor suppressor activity of GPx3 seems to relate to its ability to suppress the expression of c-met.
|
17804715 |
2007 |
|
Neoplasms
|
0.400 |
Biomarker
|
group |
BEFREE |
Interestingly, GPX3 was found at much higher levels in tumors with clear cell histology and may represent a biomarker for this subtype.
|
11358798 |
2001 |