GPX3, glutathione peroxidase 3, 2878

N. diseases: 156; N. variants: 6
Disease: Obesity ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0028754
Disease: Obesity
Obesity 		0.520 AlteredExpression disease BEFREE SC AT GPX3 expression is significantly higher in lean compared to obese as well as in insulin-sensitive compared insulin-resistant individuals with obesity. 30537708 2018
CUI: C0028754
Disease: Obesity
Obesity 		0.520 Biomarker disease CTD_human Perturbation of eight out of the nine genes, with Gas7, Me1 and Gpx3 being newly confirmed, resulted in significant changes in obesity-related traits. 19270708 2009
CUI: C0028754
Disease: Obesity
Obesity 		0.520 Biomarker disease RGD High fat feeding and dietary L-arginine supplementation differentially regulate gene expression in rat white adipose tissue. 19212806 2009
CUI: C0028754
Disease: Obesity
Obesity 		0.520 AlteredExpression disease BEFREE Taken together, these data suggest that suppression of GPx3 expression in the adipose tissue of obese subjects might constitute a vicious cycle to expand local reactive oxygen species accumulation in adipose tissue potentially into systemic oxidative stress and obesity-related metabolic complications. 18562625 2008
CUI: C0028754
Disease: Obesity
Obesity 		0.520 Biomarker disease CTD_human Effect of obesity and troglitazone on expression of two glutathione peroxidases: cellular and extracellular types in serum, kidney and adipose tissue. 11328671 2001