GRB2, growth factor receptor bound protein 2, 2885

N. diseases: 122; N. variants: 8
Disease: Carcinogenesis ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.060 Biomarker phenotype BEFREE Consequently, the Grb2 becomes the key element of this oncogenesis and launched a number of defected signaling cascades. 29173143 2018
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.060 AlteredExpression phenotype BEFREE Overexpression of GRB2 inhibited tumorigenesis in nude mice. 29730656 2018
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.060 Biomarker phenotype BEFREE We defined more precisely the gains in 17q12-q24, finding as strong candidates for ovarian tumorigenesis the genes LASP1 (17q12), TGF11 (17q21.32), MUL (17q23.2), TBX2 (17q23.2), AXIN2 (17q24.3) and GRB2 (17q25.1). 19688977 2009
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.060 Biomarker phenotype BEFREE These results suggest that the amplification of both Grb2 and SOS proteins plays an important role in the carcinogenesis of human bladder cancer. 10995035 2000
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.060 AlteredExpression phenotype BEFREE To assess the role of these molecules in mammary epithelial development and tumorigenesis, we have generated transgenic mice which individually express the Grb2 and Shc proteins in the mammary epithelium. 10567542 1999
CUI: C0596263
Disease: Carcinogenesis
Carcinogenesis 		0.060 Biomarker phenotype BEFREE These findings implicate activation of Ras function as an important component in BCR-ABL-mediated transformation and demonstrate that GRB-2 not only functions in normal development and mitogenesis but also plays a role in oncogenesis. 8402896 1993