Disease: Depressive disorder ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.380 PosttranslationalModification disease BEFREE Synaptic transmission efficacy can be bi-directionally modified through potentiation (long-term potentiation (LTP)) or depression (long-term depression (LTD)) as well as the phosphorylation state of Ser831 and Ser845 sites at the GluA1 subunit of the glutamate AMPA receptors, which has been characterized as a critical event for this synaptic plasticity. 29880883 2020
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.380 AlteredExpression disease BEFREE The (2R,6R)-HNK concentrations that increased GluA1 expression are consistent with its maximal C<sub>b,u</sub> (0.92-4.84 μM) at reportedly efficacious doses of ketamine or (2R,6R)-HNK in mouse depression models, but ≥3-fold above its projected maximal human C<sub>b,u</sub> (≤37.8 ± 14.3 nM) following ketamine's clinically antidepressant infusion. 31015046 2019
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.380 Biomarker disease BEFREE Our data indicate that capsaicin-induced modulation of LA-LTP via TRPV1 involves GluA1-containing AMPARs whereas capsaicin-induced modulation of LA-LTD via TRPM1 is independent of the expression of the AMPAR GluA1 subunit. 29246976 2018
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.380 Biomarker disease BEFREE Our study reveals that the CTDs of GluA1 and GluA2, the key subunits of AMPARs, are necessary and sufficient to drive NMDA receptor-dependent LTP and LTD, respectively. 29230056 2018
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.380 Biomarker disease BEFREE GluA1 endocytosis following chemically-induced LTD was also impaired in Stim2 cKO neurons. 27544849 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.380 Biomarker disease BEFREE PS-induced reduction of GluA1-3 subunits of AMPARs may be an important potential mechanism of offspring depression. 29019029 2017
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.380 Biomarker disease PSYGENET Here we show that tamoxifen-induced GluA1 deletion restricted to forebrain glutamatergic neurons of post-adolescent mice does not induce depression- and anxiety-like changes. 24895223 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.380 Biomarker disease PSYGENET Activity-dependent p25 generation regulates synaptic plasticity and Aβ-induced cognitive impairment. 24725413 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.380 Biomarker disease BEFREE Here we show that tamoxifen-induced GluA1 deletion restricted to forebrain glutamatergic neurons of post-adolescent mice does not induce depression- and anxiety-like changes. 24895223 2014
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.380 Biomarker disease PSYGENET The role of GluA1 in ocular dominance plasticity in the mouse visual cortex. 24048851 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.380 Biomarker disease PSYGENET Our results provide evidence for a significant role of hippocampal GluA1-containing AMPA receptors and their PDZ-interaction in experience-dependent expression of behavioral despair and link mechanisms of hippocampal synaptic plasticity with behavioral expression of depression. 23262314 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.380 Biomarker disease PSYGENET βCaMKII in lateral habenula mediates core symptoms of depression. 23990563 2013
CUI: C0011581
Disease: Depressive disorder
Depressive disorder 		0.380 GeneticVariation disease BEFREE We examined whether polymorphisms in the GRIK2, GRIA3 and GRIA1 genes were associated with selective serotonin reuptake inhibitor (SSRI)-associated sexual dysfunction in 114 participants treated for depression. 22534499 2012