TRIB2, tribbles pseudokinase 2, 28951

N. diseases: 56; N. variants: 0
Disease: Malignant neoplasm of liver ×
Source: ALL
Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver 		0.050 Biomarker disease BEFREE Trib2 pseudokinase is involved in the etiology of a number of cancers including leukaemia, melanoma, ovarian, lung and liver cancer. 29670085 2018
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver 		0.050 Biomarker disease BEFREE The tribbles homolog 2 (TRIB2) mammalian family member has been well characterized for its role in murine and human leukaemia, lung and liver cancer. 26517929 2015
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver 		0.050 Biomarker disease BEFREE Hence, we add TRIB2 to the substrate list of SCF(β-TRCP) and the finding may be helpful in the treatment of TRIB2 dependent liver cancer. 24211582 2013
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver 		0.050 AlteredExpression disease BEFREE Altogether, our study uncovers a regulatory mechanism underlying liver cancer-specific Wnt transcriptional output, and suggests that TRIB2 functions as a signaling nexus to integrate the Wnt/β-catenin, Hippo/YAP, and C/EBPα pathways in cancer cells. 23769673 2013
CUI: C0345904
Disease: Malignant neoplasm of liver
Malignant neoplasm of liver 		0.050 Biomarker disease BEFREE Recently, TRIB2 was identified as a liver cancer-specific Wnt/β-catenin signaling downstream target and is functionally important for liver cancer cell survival and transformation. 24089522 2013