Disease Score gda Association Type Type Original DB Sentence supporting the association PMID PMID Year
CUI: C0751772
Disease: REM Sleep Behavior Disorder
REM Sleep Behavior Disorder
0.100 Biomarker disease BEFREE This case showed typical RBD symptoms with REM sleep without atonia on polysomnography. 31777313 2020
CUI: C0751772
Disease: REM Sleep Behavior Disorder
REM Sleep Behavior Disorder
0.100 Biomarker disease BEFREE Future studies should include control group for the evaluation of REM sleep without atonia as marker for neurodegeneration also in non-clinical population and target RBD as precursor of neurodegeneration to develop protective trials. 30503716 2019
CUI: C0751772
Disease: REM Sleep Behavior Disorder
REM Sleep Behavior Disorder
0.100 Biomarker disease BEFREE REM sleep behaviour disorder (RBD) is characterised by violent behaviours (screaming, kicking, vivid dreams) during REM sleep. 28215911 2019
CUI: C0751772
Disease: REM Sleep Behavior Disorder
REM Sleep Behavior Disorder
0.100 GeneticVariation disease BEFREE We visually quantified phasic, "any," and tonic RSWA in the submentalis (SM) and anterior tibialis (AT) muscles, and the automated Ferri REM Atonia Index during polysomnography in adults without RBD aged 21-88. 31587043 2019
CUI: C0751772
Disease: REM Sleep Behavior Disorder
REM Sleep Behavior Disorder
0.100 AlteredExpression disease BEFREE REM sleep muscle activity in idiopathic REM sleep behavior disorder predicts phenoconversion. 31420463 2019
CUI: C0751772
Disease: REM Sleep Behavior Disorder
REM Sleep Behavior Disorder
0.100 Biomarker disease BEFREE In REM sleep, both had motor behaviors and increased phasic/tonic muscle activities confirming RBD. 31392847 2019
CUI: C0751772
Disease: REM Sleep Behavior Disorder
REM Sleep Behavior Disorder
0.100 AlteredExpression disease BEFREE Non-parametric correlations were also computed in patients with iRBD between FEOBV uptake and muscle tonic and phasic activity during REM sleep. 31078078 2019
CUI: C0751772
Disease: REM Sleep Behavior Disorder
REM Sleep Behavior Disorder
0.100 Biomarker disease BEFREE The percentages of movements and the median inter-movement distance during REM and non-REM (NREM) sleep were used for distinguishing C, RBD and PLMD by combining three optimized classifiers in a 5-fold cross-validation scheme. 30468824 2019
CUI: C0751772
Disease: REM Sleep Behavior Disorder
REM Sleep Behavior Disorder
0.100 Biomarker disease BEFREE REM Sleep without atonia correlates with abnormal vestibular-evoked myogenic potentials in isolated REM sleep behavior disorder. 31310647 2019
CUI: C0751772
Disease: REM Sleep Behavior Disorder
REM Sleep Behavior Disorder
0.100 Biomarker disease BEFREE REM sleep behavior disorder (RBD) is a parasomnia wherein a loss of REM sleep atonia manifests as dream-enactment, often violent. 29102236 2018
CUI: C0751772
Disease: REM Sleep Behavior Disorder
REM Sleep Behavior Disorder
0.100 Biomarker disease BEFREE This review addresses the neuronal substrates of REM sleep generation and modulation and how its impairment may lead to REM sleep behavior disorder. 29846796 2018
CUI: C0751772
Disease: REM Sleep Behavior Disorder
REM Sleep Behavior Disorder
0.100 Biomarker disease BEFREE Patients with iRBD were older, had an older RBD onset age and higher REM sleep phasic and tonic muscular activities than NT1-RBD. 29740055 2018
CUI: C0751772
Disease: REM Sleep Behavior Disorder
REM Sleep Behavior Disorder
0.100 Biomarker disease BEFREE We found that Parkinson's disease patients with RBD showed decreased locus coeruleus neuromelanin signal on MRI (P < 0.001) and widespread reduced binding of 11C-MeNER (P < 0.001), which correlated with amount of REM sleep without atonia. 29272343 2018
CUI: C0751772
Disease: REM Sleep Behavior Disorder
REM Sleep Behavior Disorder
0.100 Biomarker disease BEFREE To evaluate REM sleep without atonia (RSWA) in REM sleep behavior disorder (RBD) several automatic algorithms have been developed. 29773203 2018
CUI: C0751772
Disease: REM Sleep Behavior Disorder
REM Sleep Behavior Disorder
0.100 AlteredExpression disease BEFREE Ventromedial medulla inhibitory neuron inactivation induces REM sleep without atonia and REM sleep behavior disorder. 29402935 2018
CUI: C0751772
Disease: REM Sleep Behavior Disorder
REM Sleep Behavior Disorder
0.100 Biomarker disease BEFREE Dream enacting behavior (DEB) during REM sleep is a characteristic feature of REM sleep behavior disorder (RBD), the most specific prodromal symptom for Parkinson's disease (PD) and related synucleinopathies. 30007509 2018
CUI: C0751772
Disease: REM Sleep Behavior Disorder
REM Sleep Behavior Disorder
0.100 Biomarker disease BEFREE REM sleep without atonia with REM sleep-related motor events: broadening the spectrum of REM sleep behavior disorder. 30239958 2018
CUI: C0751772
Disease: REM Sleep Behavior Disorder
REM Sleep Behavior Disorder
0.100 GeneticVariation disease BEFREE Study subjects included 19 patients with late-onset psychiatric disorders who exhibited REM sleep without atonia (RWA), which is a hallmark of RBD on polysomnography, at our psychiatric ward. 29536584 2018
CUI: C0751772
Disease: REM Sleep Behavior Disorder
REM Sleep Behavior Disorder
0.100 Biomarker disease BEFREE In the late 50s Michel Jouvet discovered the presence of muscle atonia during REM sleep in cats and created the first model of REM sleep behavior disorder. 30017825 2018
CUI: C0751772
Disease: REM Sleep Behavior Disorder
REM Sleep Behavior Disorder
0.100 Biomarker disease BEFREE RBD patients seem to have a milder OSA phenotype (possible reflecting a protective role conferred by the maintenance of muscle tone during REM sleep) and to be less prone to obesity and snoring than non-RBD patients. 28673760 2017
CUI: C0751772
Disease: REM Sleep Behavior Disorder
REM Sleep Behavior Disorder
0.100 Biomarker disease BEFREE We presume that in patients with RBD and OSAS both pathologies contribute in varying degrees to the emergence of RBD symptoms by a destabilization of REM sleep. 28545360 2017
CUI: C0751772
Disease: REM Sleep Behavior Disorder
REM Sleep Behavior Disorder
0.100 Biomarker disease BEFREE To assess sleep characteristics and the occurrence of abnormal muscle activity during sleep, such as REM sleep without atonia (RSWA), REM sleep behavior disorder (RBD), and periodic leg movements during sleep (PLMS), in patients with amyotrophic lateral sclerosis (ALS). 27027974 2017
CUI: C0751772
Disease: REM Sleep Behavior Disorder
REM Sleep Behavior Disorder
0.100 Biomarker disease BEFREE Complex behaviours occurring during REM sleep were further classified as 'classically-defined' and 'pantomime-like' REM sleep behaviour disorder episodes, based on their duration and on their pattern (i.e. brief and vivid-energetic in the first case, longer and with subcontinuous gesturing mimicking daily life activity in the second case). 28472332 2017
CUI: C0751772
Disease: REM Sleep Behavior Disorder
REM Sleep Behavior Disorder
0.100 Biomarker disease BEFREE High doses are especially efficacious in REM sleep, suggesting that SO could be used to treat REM sleep behavior disorder. 28619175 2017
CUI: C0751772
Disease: REM Sleep Behavior Disorder
REM Sleep Behavior Disorder
0.100 Biomarker disease BEFREE Patients were categorized as clinical RBD (DEB and IRWA), sub-DEB positive (DEB only), subclinical RBD (IRWA only), or normal REM sleep. 28923293 2017